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  • 11.0 [archived version]
STRINGSTRING
NDOR1 NDOR1 ZNF316 ZNF316 C2orf68 C2orf68 METTL15 METTL15 AK2 AK2 HDDC2 HDDC2 CLNS1A CLNS1A RWDD1 RWDD1 CCDC42 CCDC42 DHODH DHODH DRICH1 DRICH1
"HDDC2" - HD domain containing 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurence
Coexpression
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[Homology]
Score
HDDC2HD domain containing 2; Belongs to the HDDC2 family (204 aa)    
Predicted Functional Partners:
DHODH
Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (395 aa)
   
   
  0.719
METTL15
Probable methyltransferase-like protein 15; Probable S-adenosyl-L-methionine-dependent methyltransferase (407 aa)
   
   
  0.697
C2orf68
UPF0561 protein C2orf68; Chromosome 2 open reading frame 68 (166 aa)
            
  0.612
ZNF316
Zinc finger protein 316; May be involved in transcriptional regulation; Zinc fingers C2H2-type (1004 aa)
            
  0.588
AK2
Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis (239 aa)
  
 
   
  0.571
NDOR1
NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins (By similarity). Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1; Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family (606 aa)
      
   
  0.567
RWDD1
RWD domain-containing protein 1; Protects DRG2 from proteolytic degradation; Belongs to the RWDD1/GIR2 family (243 aa)
      
   
  0.565
DRICH1
Aspartate-rich protein 1; Aspartate rich 1 (229 aa)
            
  0.556
CLNS1A
Methylosome subunit pICln; Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm comple [...] (237 aa)
      
   
  0.548
CCDC42
Coiled-coil domain-containing protein 42; Required for sperm development (316 aa)
            
  0.537
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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