| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSG00000272772 | KIAA1468 | ENSP00000430774 | ENSP00000381198 | Uncharacterized protein; Belongs to the SKP1 family | LisH domain and HEAT repeat-containing protein KIAA1468; Armadillo-like helical domain containing | 0.717 |
| ENSG00000272772 | PPP4C | ENSP00000430774 | ENSP00000279387 | Uncharacterized protein; Belongs to the SKP1 family | Serine/threonine-protein phosphatase 4 catalytic subunit; Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phospho [...] | 0.468 |
| FAM179A | HEATR2 | ENSP00000368876 | ENSP00000297440 | TOG array regulator of axonemal microtubules protein 2; Family with sequence similarity 179, member A | Dynein assembly factor 5, axonemal; Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility | 0.646 |
| FAM179A | HEATR4 | ENSP00000368876 | ENSP00000450444 | TOG array regulator of axonemal microtubules protein 2; Family with sequence similarity 179, member A | HEAT repeat-containing protein 4; Armadillo-like helical domain containing | 0.740 |
| FAM179A | HEATR6 | ENSP00000368876 | ENSP00000184956 | TOG array regulator of axonemal microtubules protein 2; Family with sequence similarity 179, member A | HEAT repeat-containing protein 6; Amplification-dependent oncogene; Armadillo-like helical domain containing | 0.721 |
| FAM179A | INTS4 | ENSP00000368876 | ENSP00000434466 | TOG array regulator of axonemal microtubules protein 2; Family with sequence similarity 179, member A | Integrator complex subunit 4; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex; Armadillo-like helical domain containing | 0.734 |
| FAM179A | KIAA1468 | ENSP00000368876 | ENSP00000381198 | TOG array regulator of axonemal microtubules protein 2; Family with sequence similarity 179, member A | LisH domain and HEAT repeat-containing protein KIAA1468; Armadillo-like helical domain containing | 0.741 |
| FAM179A | RTDR1 | ENSP00000368876 | ENSP00000216036 | TOG array regulator of axonemal microtubules protein 2; Family with sequence similarity 179, member A | Radial spoke head 14 homolog; Rhabdoid tumor deletion region gene 1; Belongs to the flagellar radial spoke RSP14 family | 0.728 |
| FAM179A | STK36 | ENSP00000368876 | ENSP00000295709 | TOG array regulator of axonemal microtubules protein 2; Family with sequence similarity 179, member A | Serine/threonine-protein kinase 36; Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of c [...] | 0.678 |
| FAM179A | TANGO6 | ENSP00000368876 | ENSP00000261778 | TOG array regulator of axonemal microtubules protein 2; Family with sequence similarity 179, member A | Transport and golgi organization 6 homolog; Armadillo-like helical domain containing | 0.768 |
| HEATR2 | FAM179A | ENSP00000297440 | ENSP00000368876 | Dynein assembly factor 5, axonemal; Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility | TOG array regulator of axonemal microtubules protein 2; Family with sequence similarity 179, member A | 0.646 |
| HEATR2 | HEATR4 | ENSP00000297440 | ENSP00000450444 | Dynein assembly factor 5, axonemal; Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility | HEAT repeat-containing protein 4; Armadillo-like helical domain containing | 0.641 |
| HEATR2 | HEATR6 | ENSP00000297440 | ENSP00000184956 | Dynein assembly factor 5, axonemal; Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility | HEAT repeat-containing protein 6; Amplification-dependent oncogene; Armadillo-like helical domain containing | 0.609 |
| HEATR2 | INTS4 | ENSP00000297440 | ENSP00000434466 | Dynein assembly factor 5, axonemal; Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility | Integrator complex subunit 4; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex; Armadillo-like helical domain containing | 0.613 |
| HEATR2 | KIAA1468 | ENSP00000297440 | ENSP00000381198 | Dynein assembly factor 5, axonemal; Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility | LisH domain and HEAT repeat-containing protein KIAA1468; Armadillo-like helical domain containing | 0.617 |
| HEATR2 | RTDR1 | ENSP00000297440 | ENSP00000216036 | Dynein assembly factor 5, axonemal; Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility | Radial spoke head 14 homolog; Rhabdoid tumor deletion region gene 1; Belongs to the flagellar radial spoke RSP14 family | 0.641 |
| HEATR2 | STK36 | ENSP00000297440 | ENSP00000295709 | Dynein assembly factor 5, axonemal; Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility | Serine/threonine-protein kinase 36; Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of c [...] | 0.603 |
| HEATR2 | TANGO6 | ENSP00000297440 | ENSP00000261778 | Dynein assembly factor 5, axonemal; Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility | Transport and golgi organization 6 homolog; Armadillo-like helical domain containing | 0.664 |
| HEATR4 | FAM179A | ENSP00000450444 | ENSP00000368876 | HEAT repeat-containing protein 4; Armadillo-like helical domain containing | TOG array regulator of axonemal microtubules protein 2; Family with sequence similarity 179, member A | 0.740 |
| HEATR4 | HEATR2 | ENSP00000450444 | ENSP00000297440 | HEAT repeat-containing protein 4; Armadillo-like helical domain containing | Dynein assembly factor 5, axonemal; Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility | 0.641 |
