node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CLP1 | MBLAC1 | ENSP00000434995 | ENSP00000381150 | Polyribonucleotide 5’-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5’- hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA-RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA-RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3’-end formation. Component of the tRNA splicing endonuclease complex- phosphorylates the 5’-terminus of the tRNA 3’-exon during tRNA splicing; this ph [...] | Metallo-beta-lactamase domain containing 1 | 0.540 |
ELFN1 | MBLAC1 | ENSP00000456548 | ENSP00000381150 | Protein ELFN1; Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and acts as a regulator of presynaptic release probability to direct the formation of highly facilitating pyramidal-OLM synapses (By similarity). Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Fibronectin type III domain containing | Metallo-beta-lactamase domain containing 1 | 0.557 |
FHAD1 | MBLAC1 | ENSP00000351770 | ENSP00000381150 | Forkhead-associated domain-containing protein 1; Forkhead associated phosphopeptide binding domain 1 | Metallo-beta-lactamase domain containing 1 | 0.567 |
FHAD1 | NEURL2 | ENSP00000351770 | ENSP00000361596 | Forkhead-associated domain-containing protein 1; Forkhead associated phosphopeptide binding domain 1 | Neuralized-like protein 2; Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity) | 0.416 |
FHAD1 | ZNF676 | ENSP00000351770 | ENSP00000380310 | Forkhead-associated domain-containing protein 1; Forkhead associated phosphopeptide binding domain 1 | Zinc finger protein 676; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.422 |
H1FNT | MBLAC1 | ENSP00000334805 | ENSP00000381150 | Testis-specific H1 histone; Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1; Histones | Metallo-beta-lactamase domain containing 1 | 0.685 |
HAGHL | LACTB2 | ENSP00000374353 | ENSP00000276590 | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds | Endoribonuclease LACTB2; Endoribonuclease; cleaves preferentially 3’ to purine- pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3’ -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | 0.471 |
HAGHL | MBLAC1 | ENSP00000374353 | ENSP00000381150 | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds | Metallo-beta-lactamase domain containing 1 | 0.653 |
HAGHL | MBLAC2 | ENSP00000374353 | ENSP00000314776 | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds | Metallo-beta-lactamase domain containing 2; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | 0.650 |
LACTB2 | HAGHL | ENSP00000276590 | ENSP00000374353 | Endoribonuclease LACTB2; Endoribonuclease; cleaves preferentially 3’ to purine- pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3’ -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds | 0.471 |
LACTB2 | MBLAC1 | ENSP00000276590 | ENSP00000381150 | Endoribonuclease LACTB2; Endoribonuclease; cleaves preferentially 3’ to purine- pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3’ -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | Metallo-beta-lactamase domain containing 1 | 0.530 |
MBLAC1 | CLP1 | ENSP00000381150 | ENSP00000434995 | Metallo-beta-lactamase domain containing 1 | Polyribonucleotide 5’-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5’- hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA-RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA-RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3’-end formation. Component of the tRNA splicing endonuclease complex- phosphorylates the 5’-terminus of the tRNA 3’-exon during tRNA splicing; this ph [...] | 0.540 |
MBLAC1 | ELFN1 | ENSP00000381150 | ENSP00000456548 | Metallo-beta-lactamase domain containing 1 | Protein ELFN1; Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and acts as a regulator of presynaptic release probability to direct the formation of highly facilitating pyramidal-OLM synapses (By similarity). Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Fibronectin type III domain containing | 0.557 |
MBLAC1 | FHAD1 | ENSP00000381150 | ENSP00000351770 | Metallo-beta-lactamase domain containing 1 | Forkhead-associated domain-containing protein 1; Forkhead associated phosphopeptide binding domain 1 | 0.567 |
MBLAC1 | H1FNT | ENSP00000381150 | ENSP00000334805 | Metallo-beta-lactamase domain containing 1 | Testis-specific H1 histone; Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1; Histones | 0.685 |
MBLAC1 | HAGHL | ENSP00000381150 | ENSP00000374353 | Metallo-beta-lactamase domain containing 1 | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds | 0.653 |
MBLAC1 | LACTB2 | ENSP00000381150 | ENSP00000276590 | Metallo-beta-lactamase domain containing 1 | Endoribonuclease LACTB2; Endoribonuclease; cleaves preferentially 3’ to purine- pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3’ -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | 0.530 |
MBLAC1 | MBLAC2 | ENSP00000381150 | ENSP00000314776 | Metallo-beta-lactamase domain containing 1 | Metallo-beta-lactamase domain containing 2; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family | 0.670 |
MBLAC1 | NEURL2 | ENSP00000381150 | ENSP00000361596 | Metallo-beta-lactamase domain containing 1 | Neuralized-like protein 2; Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity) | 0.551 |
MBLAC1 | SPRY3 | ENSP00000381150 | ENSP00000302978 | Metallo-beta-lactamase domain containing 1 | Protein sprouty homolog 3; May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis; Pseudoautosomal region 2 | 0.507 |