• Version:
  • 11.0 [archived version]
STRINGSTRING
CLP1 CLP1 ELFN1 ELFN1 H1FNT H1FNT SPRY3 SPRY3 MBLAC1 MBLAC1 NEURL2 NEURL2 MBLAC2 MBLAC2 FHAD1 FHAD1 HAGHL HAGHL ZNF676 ZNF676 LACTB2 LACTB2
"MBLAC1" - Metallo-beta-lactamase domain containing 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
Coexpression
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[Homology]
Score
MBLAC1Metallo-beta-lactamase domain containing 1 (266 aa)    
Predicted Functional Partners:
H1FNT
Testis-specific H1 histone; Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1; Histones (255 aa)
       
      0.685
MBLAC2
Metallo-beta-lactamase domain containing 2; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family (279 aa)
           
  0.670
HAGHL
Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds (282 aa)
     
   
  0.653
FHAD1
Forkhead-associated domain-containing protein 1; Forkhead associated phosphopeptide binding domain 1 (1412 aa)
           
  0.567
ELFN1
Protein ELFN1; Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and acts as a regulator of presynaptic release probability to direct the formation of highly facilitating pyramidal-OLM synapses (By similarity). Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Fibronectin type III domain containing (828 aa)
           
  0.557
NEURL2
Neuralized-like protein 2; Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity) (285 aa)
     
   
  0.551
ZNF676
Zinc finger protein 676; May be involved in transcriptional regulation; Zinc fingers C2H2-type (588 aa)
       
 
  0.547
CLP1
Polyribonucleotide 5’-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5’- hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA-RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA-RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3’-end formation. Component of the tRNA splicing endonuclease complex- phosphorylates the 5’-terminus of the tRNA 3’-exon during tRNA splicing; this ph [...] (425 aa)
       
      0.540
LACTB2
Endoribonuclease LACTB2; Endoribonuclease; cleaves preferentially 3’ to purine- pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3’ -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family (288 aa)
           
  0.530
SPRY3
Protein sprouty homolog 3; May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis; Pseudoautosomal region 2 (288 aa)
           
  0.507
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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