node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC88C | FAT3 | ENSP00000374507 | ENSP00000432586 | Protein Daple; Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization (By similarity). May also activate the JNK signaling pathway; Belongs to the CCDC88 family | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development; Cadherin related | 0.459 |
CCDC88C | FBXL12 | ENSP00000374507 | ENSP00000247977 | Protein Daple; Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization (By similarity). May also activate the JNK signaling pathway; Belongs to the CCDC88 family | F-box/LRR-repeat protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia; F-box and leucine rich repeat proteins | 0.452 |
CCDC88C | PTGDR | ENSP00000374507 | ENSP00000303424 | Protein Daple; Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization (By similarity). May also activate the JNK signaling pathway; Belongs to the CCDC88 family | Prostaglandin D2 receptor; Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity) | 0.426 |
CCDC88C | RBM14 | ENSP00000374507 | ENSP00000311747 | Protein Daple; Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization (By similarity). May also activate the JNK signaling pathway; Belongs to the CCDC88 family | RNA-binding protein 14; Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1. Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) [...] | 0.404 |
CCDC88C | TBC1D21 | ENSP00000374507 | ENSP00000300504 | Protein Daple; Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization (By similarity). May also activate the JNK signaling pathway; Belongs to the CCDC88 family | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity | 0.459 |
CCDC88C | TINAGL1 | ENSP00000374507 | ENSP00000271064 | Protein Daple; Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization (By similarity). May also activate the JNK signaling pathway; Belongs to the CCDC88 family | Tubulointerstitial nephritis antigen-like; May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity) | 0.418 |
CCDC88C | ZNF846 | ENSP00000374507 | ENSP00000380999 | Protein Daple; Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization (By similarity). May also activate the JNK signaling pathway; Belongs to the CCDC88 family | Zinc finger protein 846; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.517 |
FAT3 | CCDC88C | ENSP00000432586 | ENSP00000374507 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development; Cadherin related | Protein Daple; Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization (By similarity). May also activate the JNK signaling pathway; Belongs to the CCDC88 family | 0.459 |
FAT3 | FBXL12 | ENSP00000432586 | ENSP00000247977 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development; Cadherin related | F-box/LRR-repeat protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia; F-box and leucine rich repeat proteins | 0.446 |
FAT3 | TBC1D21 | ENSP00000432586 | ENSP00000300504 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development; Cadherin related | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity | 0.446 |
FAT3 | ZNF846 | ENSP00000432586 | ENSP00000380999 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development; Cadherin related | Zinc finger protein 846; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.469 |
FBXL12 | CCDC88C | ENSP00000247977 | ENSP00000374507 | F-box/LRR-repeat protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia; F-box and leucine rich repeat proteins | Protein Daple; Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization (By similarity). May also activate the JNK signaling pathway; Belongs to the CCDC88 family | 0.452 |
FBXL12 | FAT3 | ENSP00000247977 | ENSP00000432586 | F-box/LRR-repeat protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia; F-box and leucine rich repeat proteins | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development; Cadherin related | 0.446 |
FBXL12 | RBM14 | ENSP00000247977 | ENSP00000311747 | F-box/LRR-repeat protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia; F-box and leucine rich repeat proteins | RNA-binding protein 14; Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1. Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) [...] | 0.452 |
FBXL12 | TBC1D21 | ENSP00000247977 | ENSP00000300504 | F-box/LRR-repeat protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia; F-box and leucine rich repeat proteins | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity | 0.569 |
FBXL12 | ZNF846 | ENSP00000247977 | ENSP00000380999 | F-box/LRR-repeat protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia; F-box and leucine rich repeat proteins | Zinc finger protein 846; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.594 |
GCSAML | ZNF846 | ENSP00000446460 | ENSP00000380999 | Germinal center associated signaling and motility like | Zinc finger protein 846; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.422 |
OR5I1 | TBC1D21 | ENSP00000301532 | ENSP00000300504 | Olfactory receptor 5I1; Odorant receptor; Olfactory receptors, family 5 | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity | 0.442 |
OR5I1 | ZNF846 | ENSP00000301532 | ENSP00000380999 | Olfactory receptor 5I1; Odorant receptor; Olfactory receptors, family 5 | Zinc finger protein 846; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.489 |
PTGDR | CCDC88C | ENSP00000303424 | ENSP00000374507 | Prostaglandin D2 receptor; Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity) | Protein Daple; Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization (By similarity). May also activate the JNK signaling pathway; Belongs to the CCDC88 family | 0.426 |