• Version:
  • 11.0 [archived version]
STRINGSTRING
CENPP CENPP C6orf222 C6orf222 C3orf67 C3orf67 C6orf106 C6orf106 CABLES1 CABLES1 C17orf67 C17orf67 POC5 POC5 FAM101A FAM101A BSPH1 BSPH1 NUCKS1 NUCKS1 RUFY1 RUFY1
"C17orf67" - Uncharacterized protein C17orf67 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
C17orf67Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67 (90 aa)    
Predicted Functional Partners:
BSPH1
Binder of sperm protein homolog 1; Binds sperm in vitro and promotes sperm capacitation. Specifically promotes capacitation induced by high density lipoproteins (HDLs). Also binds heparin, phospholipid liposomes, and weakly to gelatin. Does not bind chondroitin sulfate B (132 aa)
           
  0.685
FAM101A
Refilin-A; Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in actin cytoskeleton formation in developing cartilaginous cells (135 aa)
           
  0.615
NUCKS1
Nuclear casein kinase and cyclin dependent kinase substrate 1 (243 aa)
           
  0.598
RUFY1
RUN and FYVE domain-containing protein 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking; Zinc fingers FYVE-type (708 aa)
           
  0.595
POC5
Centrosomal protein POC5; Essential for the assembly of the distal half of centrioles, required for centriole elongation; Belongs to the POC5 family (575 aa)
           
  0.580
C6orf106
Uncharacterized protein C6orf106; Chromosome 6 open reading frame 106 (298 aa)
           
  0.572
C6orf222
Uncharacterized protein C6orf222; Chromosome 6 open reading frame 222 (652 aa)
           
  0.507
C3orf67
Uncharacterized protein C3orf67; Chromosome 3 open reading frame 67 (563 aa)
           
  0.507
CENPP
Centromere protein P; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex; Constitutive centromere associated network (288 aa)
           
  0.479
CABLES1
CDK5 and ABL1 enzyme substrate 1; Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity) (633 aa)
           
  0.473
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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