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STRINGSTRING
TIAM2 TIAM2 NELL2 NELL2 VSIG8 VSIG8 PLEKHG7 PLEKHG7 C12orf74 C12orf74 KCNS3 KCNS3 LYPD6B LYPD6B ZNF485 ZNF485 FBXL16 FBXL16 TAS2R3 TAS2R3 C1orf204 C1orf204
"C12orf74" - Uncharacterized protein C12orf74 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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C12orf74Uncharacterized protein C12orf74; Chromosome 12 open reading frame 74 (190 aa)    
Predicted Functional Partners:
ZNF485
Zinc finger protein 485; May be involved in transcriptional regulation; Zinc fingers C2H2-type (441 aa)
            
  0.671
PLEKHG7
Pleckstrin homology and RhoGEF domain containing G7 (379 aa)
  
            0.595
FBXL16
F-box/LRR-repeat protein 16; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins (479 aa)
            
  0.586
C1orf204
Putative uncharacterized protein SNHG28; Chromosome 1 open reading frame 204 (235 aa)
            
  0.578
VSIG8
V-set and immunoglobulin domain containing 8; IgCAM CXADR-related subfamily (414 aa)
            
  0.572
LYPD6B
Ly6/PLAUR domain-containing protein 6B; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifally alpha-3(3)-beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2)-alpha- 5-beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn- 398 but not its wild-type sequence; LY6/PLAUR domain containing (207 aa)
            
  0.571
TAS2R3
Taste receptor type 2 member 3; Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (316 aa)
            
  0.570
KCNS3
Potassium voltage-gated channel subfamily S member 3; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity) (491 aa)
            
  0.472
TIAM2
T-lymphoma invasion and metastasis-inducing protein 2; Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling acc [...] (1701 aa)
            
  0.441
NELL2
Protein kinase C-binding protein NELL2; Required for neuron survival through the modulation of MAPK pathways (By similarity). Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity) (866 aa)
            
  0.429
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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