node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADI1 | DROSHA | ENSP00000333666 | ENSP00000425979 | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line | Ribonuclease 3; Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3’ and 5’ strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA- ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Invo [...] | 0.545 |
ADI1 | PQLC1 | ENSP00000333666 | ENSP00000380880 | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line | PQ-loop repeat-containing protein 1; PQ loop repeat containing 1 | 0.576 |
ATP9B | PQLC1 | ENSP00000398076 | ENSP00000380880 | Probable phospholipid-transporting ATPase IIB; ATPase phospholipid transporting 9B | PQ-loop repeat-containing protein 1; PQ loop repeat containing 1 | 0.660 |
BRD9 | CLPTM1L | ENSP00000419765 | ENSP00000313854 | Bromodomain-containing protein 9; Plays a role in chromatin remodeling and regulation of transcription. Acts as a chromatin reader that recognizes and binds acylated histones- binds histones that are acetylated and/or butyrylated; BAF complex | Cleft lip and palate transmembrane protein 1-like protein; Enhances cisplatin-mediated apoptosis, when overexpressed; Belongs to the CLPTM1 family | 0.472 |
BRD9 | PQLC1 | ENSP00000419765 | ENSP00000380880 | Bromodomain-containing protein 9; Plays a role in chromatin remodeling and regulation of transcription. Acts as a chromatin reader that recognizes and binds acylated histones- binds histones that are acetylated and/or butyrylated; BAF complex | PQ-loop repeat-containing protein 1; PQ loop repeat containing 1 | 0.545 |
CLPTM1L | BRD9 | ENSP00000313854 | ENSP00000419765 | Cleft lip and palate transmembrane protein 1-like protein; Enhances cisplatin-mediated apoptosis, when overexpressed; Belongs to the CLPTM1 family | Bromodomain-containing protein 9; Plays a role in chromatin remodeling and regulation of transcription. Acts as a chromatin reader that recognizes and binds acylated histones- binds histones that are acetylated and/or butyrylated; BAF complex | 0.472 |
CLPTM1L | PQLC1 | ENSP00000313854 | ENSP00000380880 | Cleft lip and palate transmembrane protein 1-like protein; Enhances cisplatin-mediated apoptosis, when overexpressed; Belongs to the CLPTM1 family | PQ-loop repeat-containing protein 1; PQ loop repeat containing 1 | 0.523 |
CTNS | PQLC1 | ENSP00000371294 | ENSP00000380880 | Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family | PQ-loop repeat-containing protein 1; PQ loop repeat containing 1 | 0.636 |
CTNS | PQLC2 | ENSP00000371294 | ENSP00000364295 | Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family | Lysosomal amino acid transporter 1 homolog; Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes | 0.874 |
DROSHA | ADI1 | ENSP00000425979 | ENSP00000333666 | Ribonuclease 3; Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3’ and 5’ strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA- ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Invo [...] | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line | 0.545 |
DROSHA | PQLC1 | ENSP00000425979 | ENSP00000380880 | Ribonuclease 3; Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3’ and 5’ strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA- ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Invo [...] | PQ-loop repeat-containing protein 1; PQ loop repeat containing 1 | 0.543 |
HDHD3 | PQLC1 | ENSP00000238379 | ENSP00000380880 | Haloacid dehalogenase like hydrolase domain containing 3 | PQ-loop repeat-containing protein 1; PQ loop repeat containing 1 | 0.568 |
MGLL | PQLC1 | ENSP00000265052 | ENSP00000380880 | Monoglyceride lipase; Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth; Lipases | PQ-loop repeat-containing protein 1; PQ loop repeat containing 1 | 0.566 |
PQLC1 | ADI1 | ENSP00000380880 | ENSP00000333666 | PQ-loop repeat-containing protein 1; PQ loop repeat containing 1 | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line | 0.576 |
PQLC1 | ATP9B | ENSP00000380880 | ENSP00000398076 | PQ-loop repeat-containing protein 1; PQ loop repeat containing 1 | Probable phospholipid-transporting ATPase IIB; ATPase phospholipid transporting 9B | 0.660 |
PQLC1 | BRD9 | ENSP00000380880 | ENSP00000419765 | PQ-loop repeat-containing protein 1; PQ loop repeat containing 1 | Bromodomain-containing protein 9; Plays a role in chromatin remodeling and regulation of transcription. Acts as a chromatin reader that recognizes and binds acylated histones- binds histones that are acetylated and/or butyrylated; BAF complex | 0.545 |
PQLC1 | CLPTM1L | ENSP00000380880 | ENSP00000313854 | PQ-loop repeat-containing protein 1; PQ loop repeat containing 1 | Cleft lip and palate transmembrane protein 1-like protein; Enhances cisplatin-mediated apoptosis, when overexpressed; Belongs to the CLPTM1 family | 0.523 |
PQLC1 | CTNS | ENSP00000380880 | ENSP00000371294 | PQ-loop repeat-containing protein 1; PQ loop repeat containing 1 | Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family | 0.636 |
PQLC1 | DROSHA | ENSP00000380880 | ENSP00000425979 | PQ-loop repeat-containing protein 1; PQ loop repeat containing 1 | Ribonuclease 3; Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3’ and 5’ strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA- ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Invo [...] | 0.543 |
PQLC1 | HDHD3 | ENSP00000380880 | ENSP00000238379 | PQ-loop repeat-containing protein 1; PQ loop repeat containing 1 | Haloacid dehalogenase like hydrolase domain containing 3 | 0.568 |