node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRWD1 | ZBTB44 | ENSP00000330753 | ENSP00000380861 | Bromodomain and WD repeat-containing protein 1; May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape; Bromodomain containing | Zinc finger and BTB domain-containing protein 44; May be involved in transcriptional regulation; BTB domain containing | 0.477 |
C14orf93 | CEP250 | ENSP00000299088 | ENSP00000380661 | Uncharacterized protein C14orf93; Chromosome 14 open reading frame 93 | Centrosome-associated protein CEP250; Probably plays an important role in centrosome cohesion during interphase | 0.511 |
C14orf93 | ZBTB44 | ENSP00000299088 | ENSP00000380861 | Uncharacterized protein C14orf93; Chromosome 14 open reading frame 93 | Zinc finger and BTB domain-containing protein 44; May be involved in transcriptional regulation; BTB domain containing | 0.744 |
CEP250 | C14orf93 | ENSP00000380661 | ENSP00000299088 | Centrosome-associated protein CEP250; Probably plays an important role in centrosome cohesion during interphase | Uncharacterized protein C14orf93; Chromosome 14 open reading frame 93 | 0.511 |
CEP250 | ZBTB44 | ENSP00000380661 | ENSP00000380861 | Centrosome-associated protein CEP250; Probably plays an important role in centrosome cohesion during interphase | Zinc finger and BTB domain-containing protein 44; May be involved in transcriptional regulation; BTB domain containing | 0.486 |
NAE1 | ZBTB44 | ENSP00000351990 | ENSP00000380861 | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation; Ubiquitin like modifier activating enzymes | Zinc finger and BTB domain-containing protein 44; May be involved in transcriptional regulation; BTB domain containing | 0.559 |
NBEAL1 | PTPN4 | ENSP00000399903 | ENSP00000263708 | Neurobeachin-like protein 1; Armadillo-like helical domain containing; Belongs to the WD repeat neurobeachin family | Tyrosine-protein phosphatase non-receptor type 4; May act at junctions between the membrane and the cytoskeleton; Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily | 0.662 |
NBEAL1 | SERTAD4 | ENSP00000399903 | ENSP00000355979 | Neurobeachin-like protein 1; Armadillo-like helical domain containing; Belongs to the WD repeat neurobeachin family | SERTA domain containing 4 | 0.717 |
NBEAL1 | YPEL2 | ENSP00000399903 | ENSP00000312272 | Neurobeachin-like protein 1; Armadillo-like helical domain containing; Belongs to the WD repeat neurobeachin family | Protein yippee-like 2; Yippee like family | 0.740 |
NBEAL1 | ZBTB44 | ENSP00000399903 | ENSP00000380861 | Neurobeachin-like protein 1; Armadillo-like helical domain containing; Belongs to the WD repeat neurobeachin family | Zinc finger and BTB domain-containing protein 44; May be involved in transcriptional regulation; BTB domain containing | 0.725 |
PCGF5 | YOD1 | ENSP00000445704 | ENSP00000326813 | Polycomb group RING finger protein 5; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ’Lys-119’, rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates mon [...] | Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP’s axial channel. Mediates deubiquitination of ’Lys-27’-, ’Lys-29’- and ’Lys-33’-linked polyubiquitin chains. A [...] | 0.449 |
PCGF5 | ZBTB44 | ENSP00000445704 | ENSP00000380861 | Polycomb group RING finger protein 5; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ’Lys-119’, rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates mon [...] | Zinc finger and BTB domain-containing protein 44; May be involved in transcriptional regulation; BTB domain containing | 0.514 |
PTPN4 | NBEAL1 | ENSP00000263708 | ENSP00000399903 | Tyrosine-protein phosphatase non-receptor type 4; May act at junctions between the membrane and the cytoskeleton; Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily | Neurobeachin-like protein 1; Armadillo-like helical domain containing; Belongs to the WD repeat neurobeachin family | 0.662 |
PTPN4 | YPEL2 | ENSP00000263708 | ENSP00000312272 | Tyrosine-protein phosphatase non-receptor type 4; May act at junctions between the membrane and the cytoskeleton; Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily | Protein yippee-like 2; Yippee like family | 0.638 |
PTPN4 | ZBTB44 | ENSP00000263708 | ENSP00000380861 | Tyrosine-protein phosphatase non-receptor type 4; May act at junctions between the membrane and the cytoskeleton; Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily | Zinc finger and BTB domain-containing protein 44; May be involved in transcriptional regulation; BTB domain containing | 0.618 |
SERTAD4 | NBEAL1 | ENSP00000355979 | ENSP00000399903 | SERTA domain containing 4 | Neurobeachin-like protein 1; Armadillo-like helical domain containing; Belongs to the WD repeat neurobeachin family | 0.717 |
SERTAD4 | YPEL2 | ENSP00000355979 | ENSP00000312272 | SERTA domain containing 4 | Protein yippee-like 2; Yippee like family | 0.705 |
SERTAD4 | ZBTB44 | ENSP00000355979 | ENSP00000380861 | SERTA domain containing 4 | Zinc finger and BTB domain-containing protein 44; May be involved in transcriptional regulation; BTB domain containing | 0.658 |
YOD1 | PCGF5 | ENSP00000326813 | ENSP00000445704 | Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP’s axial channel. Mediates deubiquitination of ’Lys-27’-, ’Lys-29’- and ’Lys-33’-linked polyubiquitin chains. A [...] | Polycomb group RING finger protein 5; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ’Lys-119’, rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates mon [...] | 0.449 |
YOD1 | ZBTB44 | ENSP00000326813 | ENSP00000380861 | Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP’s axial channel. Mediates deubiquitination of ’Lys-27’-, ’Lys-29’- and ’Lys-33’-linked polyubiquitin chains. A [...] | Zinc finger and BTB domain-containing protein 44; May be involved in transcriptional regulation; BTB domain containing | 0.501 |