node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CEP19 | SMCO1 | ENSP00000387209 | ENSP00000380671 | Centrosomal protein of 19 kDa; Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring to the centrosomes | Single-pass membrane protein with coiled-coil domains 1 | 0.554 |
CEP19 | TM4SF19 | ENSP00000387209 | ENSP00000273695 | Centrosomal protein of 19 kDa; Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring to the centrosomes | Transmembrane 4 L six family member 19; Belongs to the L6 tetraspanin family | 0.414 |
CEP19 | WDR53 | ENSP00000387209 | ENSP00000328079 | Centrosomal protein of 19 kDa; Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring to the centrosomes | WD repeat-containing protein 53; WD repeat domain containing; Belongs to the WD repeat WDR53 family | 0.526 |
CEP19 | ZDHHC19 | ENSP00000387209 | ENSP00000296326 | Centrosomal protein of 19 kDa; Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring to the centrosomes | Probable palmitoyltransferase ZDHHC19; Zinc finger DHHC-type containing 19; Belongs to the DHHC palmitoyltransferase family | 0.437 |
FAM160A1 | SMCO1 | ENSP00000413196 | ENSP00000380671 | Protein FAM160A1; Family with sequence similarity 160 member A1; Belongs to the UPF0518 family | Single-pass membrane protein with coiled-coil domains 1 | 0.669 |
FAM160A1 | TRIML1 | ENSP00000413196 | ENSP00000327738 | Protein FAM160A1; Family with sequence similarity 160 member A1; Belongs to the UPF0518 family | Probable E3 ubiquitin-protein ligase TRIML1; Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development; Ring finger proteins | 0.530 |
FNDC8 | SMCO1 | ENSP00000158009 | ENSP00000380671 | Fibronectin type III domain containing 8 | Single-pass membrane protein with coiled-coil domains 1 | 0.548 |
MAPK8IP3 | SMCO1 | ENSP00000250894 | ENSP00000380671 | C-Jun-amino-terminal kinase-interacting protein 3; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity) | Single-pass membrane protein with coiled-coil domains 1 | 0.862 |
MAPK8IP3 | SPAG9 | ENSP00000250894 | ENSP00000262013 | C-Jun-amino-terminal kinase-interacting protein 3; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity) | C-Jun-amino-terminal kinase-interacting protein 4; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg- interaction | 0.559 |
SMCO1 | CEP19 | ENSP00000380671 | ENSP00000387209 | Single-pass membrane protein with coiled-coil domains 1 | Centrosomal protein of 19 kDa; Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring to the centrosomes | 0.554 |
SMCO1 | FAM160A1 | ENSP00000380671 | ENSP00000413196 | Single-pass membrane protein with coiled-coil domains 1 | Protein FAM160A1; Family with sequence similarity 160 member A1; Belongs to the UPF0518 family | 0.669 |
SMCO1 | FNDC8 | ENSP00000380671 | ENSP00000158009 | Single-pass membrane protein with coiled-coil domains 1 | Fibronectin type III domain containing 8 | 0.548 |
SMCO1 | MAPK8IP3 | ENSP00000380671 | ENSP00000250894 | Single-pass membrane protein with coiled-coil domains 1 | C-Jun-amino-terminal kinase-interacting protein 3; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity) | 0.862 |
SMCO1 | SMCO2 | ENSP00000380671 | ENSP00000387617 | Single-pass membrane protein with coiled-coil domains 1 | Single-pass membrane protein with coiled-coil domains 2 | 0.673 |
SMCO1 | SPAG9 | ENSP00000380671 | ENSP00000262013 | Single-pass membrane protein with coiled-coil domains 1 | C-Jun-amino-terminal kinase-interacting protein 4; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg- interaction | 0.686 |
SMCO1 | TM4SF19 | ENSP00000380671 | ENSP00000273695 | Single-pass membrane protein with coiled-coil domains 1 | Transmembrane 4 L six family member 19; Belongs to the L6 tetraspanin family | 0.530 |
SMCO1 | TRIML1 | ENSP00000380671 | ENSP00000327738 | Single-pass membrane protein with coiled-coil domains 1 | Probable E3 ubiquitin-protein ligase TRIML1; Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development; Ring finger proteins | 0.530 |
SMCO1 | WDR53 | ENSP00000380671 | ENSP00000328079 | Single-pass membrane protein with coiled-coil domains 1 | WD repeat-containing protein 53; WD repeat domain containing; Belongs to the WD repeat WDR53 family | 0.642 |
SMCO1 | ZDHHC19 | ENSP00000380671 | ENSP00000296326 | Single-pass membrane protein with coiled-coil domains 1 | Probable palmitoyltransferase ZDHHC19; Zinc finger DHHC-type containing 19; Belongs to the DHHC palmitoyltransferase family | 0.552 |
SMCO2 | SMCO1 | ENSP00000387617 | ENSP00000380671 | Single-pass membrane protein with coiled-coil domains 2 | Single-pass membrane protein with coiled-coil domains 1 | 0.673 |