• Version:
  • 11.0 [archived version]
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FNDC8 FNDC8 SMCO2 SMCO2 FAM160A1 FAM160A1 ZDHHC19 ZDHHC19 SMCO1 SMCO1 WDR53 WDR53 TRIML1 TRIML1 CEP19 CEP19 TM4SF19 TM4SF19 MAPK8IP3 MAPK8IP3 SPAG9 SPAG9
"SMCO1" - Single-pass membrane protein with coiled-coil domains 1 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurence
Coexpression
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[Homology]
Score
SMCO1Single-pass membrane protein with coiled-coil domains 1 (214 aa)    
Predicted Functional Partners:
MAPK8IP3
C-Jun-amino-terminal kinase-interacting protein 3; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity) (1336 aa)
       
      0.862
SPAG9
C-Jun-amino-terminal kinase-interacting protein 4; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg- interaction (1321 aa)
       
      0.686
SMCO2
Single-pass membrane protein with coiled-coil domains 2 (343 aa)
           
  0.673
FAM160A1
Protein FAM160A1; Family with sequence similarity 160 member A1; Belongs to the UPF0518 family (1040 aa)
           
  0.669
WDR53
WD repeat-containing protein 53; WD repeat domain containing; Belongs to the WD repeat WDR53 family (358 aa)
           
  0.642
CEP19
Centrosomal protein of 19 kDa; Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19-RABL2B complex binds intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia. Involved in the early steps in cilia formation by recruiting the ciliary vesicles (CVs) to the distal end of the mother centriole where they fuse to initiate cilium assembly. Involved in microtubule (MT) anchoring to the centrosomes (167 aa)
           
  0.554
ZDHHC19
Probable palmitoyltransferase ZDHHC19; Zinc finger DHHC-type containing 19; Belongs to the DHHC palmitoyltransferase family (309 aa)
           
  0.552
FNDC8
Fibronectin type III domain containing 8 (324 aa)
       
      0.548
TRIML1
Probable E3 ubiquitin-protein ligase TRIML1; Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development; Ring finger proteins (468 aa)
           
  0.530
TM4SF19
Transmembrane 4 L six family member 19; Belongs to the L6 tetraspanin family (209 aa)
           
  0.530
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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