BPIFC protein (human) - STRING database

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BPIFC

BPI fold containing family C (507 aa)

Predicted Functional Partners:

DHRS9

0.606

BPIFA1

0.605

PLEKHA4

0.601

IQCD

0.590

CDK5RAP1

0.514

PRR34

0.511

BPIFB1

0.508

HGNC:9979

0.477

RFPL3

0.473

NRIP1

0.471

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BPIFA1	BPIFB1	ENSP00000346251	ENSP00000253354	BPI fold-containing family A member 1; Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory [...]	BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS; Belongs to the BPI/LBP/Plunc superfamily. Plunc family	0.418
BPIFA1	BPIFC	ENSP00000346251	ENSP00000380594	BPI fold-containing family A member 1; Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory [...]	BPI fold containing family C	0.605
BPIFB1	BPIFA1	ENSP00000253354	ENSP00000346251	BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS; Belongs to the BPI/LBP/Plunc superfamily. Plunc family	BPI fold-containing family A member 1; Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory [...]	0.418
BPIFB1	BPIFC	ENSP00000253354	ENSP00000380594	BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS; Belongs to the BPI/LBP/Plunc superfamily. Plunc family	BPI fold containing family C	0.508
BPIFC	BPIFA1	ENSP00000380594	ENSP00000346251	BPI fold containing family C	BPI fold-containing family A member 1; Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory [...]	0.605
BPIFC	BPIFB1	ENSP00000380594	ENSP00000253354	BPI fold containing family C	BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS; Belongs to the BPI/LBP/Plunc superfamily. Plunc family	0.508
BPIFC	CDK5RAP1	ENSP00000380594	ENSP00000217372	BPI fold containing family C	CDK5 regulatory subunit-associated protein 1; Specifically inhibits CDK5 activation by CDK5R1	0.514
BPIFC	DHRS9	ENSP00000380594	ENSP00000389241	BPI fold containing family C	Dehydrogenase/reductase SDR family member 9; 3-alpha-hydroxysteroid dehydrogenase that converts 3- alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH; Belongs to the short-chain dehydrogenases/reductases (SDR) family	0.606
BPIFC	HGNC:9979	ENSP00000380594	ENSP00000383096	BPI fold containing family C	Ret finger protein-like 2	0.477
BPIFC	IQCD	ENSP00000380594	ENSP00000299732	BPI fold containing family C	IQ domain-containing protein D; Cilia and flagella associated	0.590
BPIFC	NRIP1	ENSP00000380594	ENSP00000383063	BPI fold containing family C	Nuclear receptor-interacting protein 1; Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression- stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC	0.471
BPIFC	PLEKHA4	ENSP00000380594	ENSP00000263265	BPI fold containing family C	Pleckstrin homology domain-containing family A member 4; Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides; Pleckstrin homology domain containing	0.601
BPIFC	PRR34	ENSP00000380594	ENSP00000379329	BPI fold containing family C	Proline-rich protein 34; Proline rich 34	0.511
BPIFC	RFPL3	ENSP00000380594	ENSP00000249007	BPI fold containing family C	Ret finger protein-like 3; (Microbial infection) Stimulates the activity of Human Immunodeficiency Virus 1/HIV-1 pre-integration complex; Ring finger proteins	0.473
CDK5RAP1	BPIFC	ENSP00000217372	ENSP00000380594	CDK5 regulatory subunit-associated protein 1; Specifically inhibits CDK5 activation by CDK5R1	BPI fold containing family C	0.514
DHRS9	BPIFC	ENSP00000389241	ENSP00000380594	Dehydrogenase/reductase SDR family member 9; 3-alpha-hydroxysteroid dehydrogenase that converts 3- alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH; Belongs to the short-chain dehydrogenases/reductases (SDR) family	BPI fold containing family C	0.606
DHRS9	NRIP1	ENSP00000389241	ENSP00000383063	Dehydrogenase/reductase SDR family member 9; 3-alpha-hydroxysteroid dehydrogenase that converts 3- alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH; Belongs to the short-chain dehydrogenases/reductases (SDR) family	Nuclear receptor-interacting protein 1; Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression- stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC	0.457
HGNC:9979	BPIFC	ENSP00000383096	ENSP00000380594	Ret finger protein-like 2	BPI fold containing family C	0.477
IQCD	BPIFC	ENSP00000299732	ENSP00000380594	IQ domain-containing protein D; Cilia and flagella associated	BPI fold containing family C	0.590
NRIP1	BPIFC	ENSP00000383063	ENSP00000380594	Nuclear receptor-interacting protein 1; Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression- stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC	BPI fold containing family C	0.471

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