• Version:
  • 11.0 [archived version]
STRINGSTRING
LHFPL4 LHFPL4 PMP22 PMP22 PLP1 PLP1 LHFPL3 LHFPL3 ASPDH ASPDH TSPAN4 TSPAN4 LHFPL5 LHFPL5 UPK3A UPK3A EMP2 EMP2 TM4SF4 TM4SF4 TM4SF1 TM4SF1
"TSPAN4" - Tetraspanin-4 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TSPAN4Tetraspanin-4; Tetraspanin 4; Belongs to the tetraspanin (TM4SF) family (238 aa)    
Predicted Functional Partners:
TM4SF4
Transmembrane 4 L6 family member 4; Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation (202 aa)
            
  0.802
LHFPL4
LHFPL tetraspan subfamily member 4 (247 aa)
            
  0.800
LHFPL3
LHFPL tetraspan subfamily member 3 (222 aa)
            
  0.745
LHFPL5
LHFPL tetraspan subfamily member 5 protein; In the inner ear, may be a component of the hair cell’s mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation (By similarity); Deafness associated genes (219 aa)
            
  0.719
ASPDH
Putative L-aspartate dehydrogenase; Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (283 aa)
            
  0.703
PMP22
Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family (160 aa)
      
   
  0.698
PLP1
Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin; Belongs to the myelin proteolipid protein family (277 aa)
            
  0.675
EMP2
Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation. Facilitates surface trafficking and formation of lipid rafts bearing GPI-anchor proteins (By similarity). Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cyto [...] (167 aa)
            
  0.669
TM4SF1
Transmembrane 4 L six family member 1 (202 aa)
      
   
  0.655
UPK3A
Uroplakin-3a; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity) (287 aa)
        
 
  0.652
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]
STRING is part of the ELIXIR infrastructure: it is one of ELIXIR's Core Data Resources.  Learn more >