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STRINGSTRING
C10orf35 C10orf35 UBE2O UBE2O DNER DNER CNOT7 CNOT7 RSF1 RSF1 SFMBT2 SFMBT2 DAD1 DAD1 ITIH5 ITIH5 FAM81A FAM81A ANKRD16 ANKRD16 TMED6 TMED6
"SFMBT2" - Scm-like with four MBT domains protein 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SFMBT2Scm-like with four MBT domains protein 2; Transcriptional repressor of HOXB13 gene; MBT domain containing (894 aa)    
Predicted Functional Partners:
RSF1
Remodeling and spacing factor 1; Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex. Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain; PHD finger proteins (1441 aa)
      
   
  0.590
DNER
Delta and Notch-like epidermal growth factor-related receptor; Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity) (737 aa)
      
   
  0.568
UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme; E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins. Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity. Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis. Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chrom [...] (1292 aa)
      
      0.540
ANKRD16
Ankyrin repeat domain-containing protein 16; Ankyrin repeat domain containing (361 aa)
        
 
  0.505
ITIH5
Inter-alpha-trypsin inhibitor heavy chain H5; May act as a tumor suppressor (942 aa)
            
  0.505
CNOT7
CCR4-NOT transcription complex subunit 7; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translationa [...] (285 aa)
            
  0.503
FAM81A
Protein FAM81A; Family with sequence similarity 81 member A; Belongs to the FAM81 family (368 aa)
            
  0.496
DAD1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for the assembly of both SST3A- and SS3B-containing OST complexes. Required for efficient N-glycosylation. Loss of the DAD1 protein triggers apoptosis; Belongs to the DAD/OST2 family (113 aa)
            
  0.495
TMED6
Transmembrane p24 trafficking protein 6 (240 aa)
            
  0.494
C10orf35
Uncharacterized protein FAM241B; Chromosome 10 open reading frame 35 (121 aa)
            
  0.491
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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