| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CAPN3 | CAPNS1 | ENSP00000380349 | ENSP00000246533 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Calpains | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; EF-hand domain containing | 0.911 |
| CAPN3 | CAPNS2 | ENSP00000380349 | ENSP00000400882 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Calpains | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity; EF-hand domain containing | 0.908 |
| CAPN3 | CAST | ENSP00000380349 | ENSP00000379157 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Calpains | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family | 0.943 |
| CAPN3 | DYSF | ENSP00000380349 | ENSP00000386881 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Calpains | Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity); Ferlin family | 0.909 |
| CAPN3 | FKRP | ENSP00000380349 | ENSP00000326570 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Calpains | Fukutin-related protein; Transferase involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine- beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity | 0.669 |
| CAPN3 | LAMA2 | ENSP00000380349 | ENSP00000400365 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Calpains | Laminin subunit alpha-2; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | 0.670 |
| CAPN3 | MYOT | ENSP00000380349 | ENSP00000239926 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Calpains | Myotilin; Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells; I-set domain containing | 0.682 |
| CAPN3 | TRIM32 | ENSP00000380349 | ENSP00000408292 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Calpains | E3 ubiquitin-protein ligase TRIM32; Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo; Belongs to the TRIM/RBCC family | 0.692 |
| CAPN3 | TRIM71 | ENSP00000380349 | ENSP00000373272 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Calpains | E3 ubiquitin-protein ligase TRIM71; E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and preven [...] | 0.712 |
| CAPN3 | TTN | ENSP00000380349 | ENSP00000467141 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Calpains | Titin; Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase; Fibronectin type III domain containing | 0.840 |
| CAPNS1 | CAPN3 | ENSP00000246533 | ENSP00000380349 | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; EF-hand domain containing | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Calpains | 0.911 |
| CAPNS1 | CAPNS2 | ENSP00000246533 | ENSP00000400882 | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; EF-hand domain containing | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity; EF-hand domain containing | 0.920 |
| CAPNS1 | CAST | ENSP00000246533 | ENSP00000379157 | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; EF-hand domain containing | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family | 0.982 |
| CAPNS2 | CAPN3 | ENSP00000400882 | ENSP00000380349 | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity; EF-hand domain containing | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Calpains | 0.908 |
| CAPNS2 | CAPNS1 | ENSP00000400882 | ENSP00000246533 | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity; EF-hand domain containing | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; EF-hand domain containing | 0.920 |
| CAPNS2 | CAST | ENSP00000400882 | ENSP00000379157 | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity; EF-hand domain containing | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family | 0.980 |
| CAST | CAPN3 | ENSP00000379157 | ENSP00000380349 | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Calpains | 0.943 |
| CAST | CAPNS1 | ENSP00000379157 | ENSP00000246533 | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; EF-hand domain containing | 0.982 |
| CAST | CAPNS2 | ENSP00000379157 | ENSP00000400882 | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity; EF-hand domain containing | 0.980 |
| CAST | TTN | ENSP00000379157 | ENSP00000467141 | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family | Titin; Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase; Fibronectin type III domain containing | 0.463 |
