node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKRD16 | ITIH5 | ENSP00000369436 | ENSP00000380333 | Ankyrin repeat domain-containing protein 16; Ankyrin repeat domain containing | Inter-alpha-trypsin inhibitor heavy chain H5; May act as a tumor suppressor | 0.562 |
CHCHD3 | CHCHD6 | ENSP00000262570 | ENSP00000290913 | MICOS complex subunit MIC19; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology; Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins | MICOS complex subunit MIC25; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily | 0.934 |
CHCHD3 | ITIH5 | ENSP00000262570 | ENSP00000380333 | MICOS complex subunit MIC19; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology; Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins | Inter-alpha-trypsin inhibitor heavy chain H5; May act as a tumor suppressor | 0.563 |
CHCHD3 | PNCK | ENSP00000262570 | ENSP00000405950 | MICOS complex subunit MIC19; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology; Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins | Calcium/calmodulin-dependent protein kinase type 1B; Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity) | 0.597 |
CHCHD3 | SFMBT1 | ENSP00000262570 | ENSP00000378235 | MICOS complex subunit MIC19; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology; Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins | Scm-like with four MBT domains protein 1; Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis- required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis; [...] | 0.583 |
CHCHD3 | TIMM17A | ENSP00000262570 | ENSP00000356256 | MICOS complex subunit MIC19; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology; Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins | Mitochondrial import inner membrane translocase subunit Tim17-A; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane | 0.664 |
CHCHD3 | TMCC1 | ENSP00000262570 | ENSP00000376930 | MICOS complex subunit MIC19; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology; Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins | Transmembrane and coiled-coil domain containing | 0.646 |
CHCHD6 | CHCHD3 | ENSP00000290913 | ENSP00000262570 | MICOS complex subunit MIC25; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily | MICOS complex subunit MIC19; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology; Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins | 0.934 |
CHCHD6 | ITIH5 | ENSP00000290913 | ENSP00000380333 | MICOS complex subunit MIC25; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily | Inter-alpha-trypsin inhibitor heavy chain H5; May act as a tumor suppressor | 0.540 |
CHCHD6 | PNCK | ENSP00000290913 | ENSP00000405950 | MICOS complex subunit MIC25; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily | Calcium/calmodulin-dependent protein kinase type 1B; Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity) | 0.632 |
CHCHD6 | SFMBT1 | ENSP00000290913 | ENSP00000378235 | MICOS complex subunit MIC25; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily | Scm-like with four MBT domains protein 1; Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis- required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis; [...] | 0.532 |
CHCHD6 | TIMM17A | ENSP00000290913 | ENSP00000356256 | MICOS complex subunit MIC25; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily | Mitochondrial import inner membrane translocase subunit Tim17-A; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane | 0.686 |
CHCHD6 | TMCC1 | ENSP00000290913 | ENSP00000376930 | MICOS complex subunit MIC25; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily | Transmembrane and coiled-coil domain containing | 0.609 |
GRAMD1B | ITIH5 | ENSP00000402457 | ENSP00000380333 | GRAM domain containing 1B | Inter-alpha-trypsin inhibitor heavy chain H5; May act as a tumor suppressor | 0.540 |
ITIH5 | ANKRD16 | ENSP00000380333 | ENSP00000369436 | Inter-alpha-trypsin inhibitor heavy chain H5; May act as a tumor suppressor | Ankyrin repeat domain-containing protein 16; Ankyrin repeat domain containing | 0.562 |
ITIH5 | CHCHD3 | ENSP00000380333 | ENSP00000262570 | Inter-alpha-trypsin inhibitor heavy chain H5; May act as a tumor suppressor | MICOS complex subunit MIC19; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology; Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins | 0.563 |
ITIH5 | CHCHD6 | ENSP00000380333 | ENSP00000290913 | Inter-alpha-trypsin inhibitor heavy chain H5; May act as a tumor suppressor | MICOS complex subunit MIC25; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily | 0.540 |
ITIH5 | GRAMD1B | ENSP00000380333 | ENSP00000402457 | Inter-alpha-trypsin inhibitor heavy chain H5; May act as a tumor suppressor | GRAM domain containing 1B | 0.540 |
ITIH5 | LMBRD2 | ENSP00000380333 | ENSP00000296603 | Inter-alpha-trypsin inhibitor heavy chain H5; May act as a tumor suppressor | LMBR1 domain containing 2 | 0.523 |
ITIH5 | PNCK | ENSP00000380333 | ENSP00000405950 | Inter-alpha-trypsin inhibitor heavy chain H5; May act as a tumor suppressor | Calcium/calmodulin-dependent protein kinase type 1B; Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity) | 0.537 |