| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACYP2 | CTC1 | ENSP00000378161 | ENSP00000313759 | Acylphosphatase-2; Its physiological role is not yet clear | CST complex subunit CTC1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...] | 0.630 |
| ACYP2 | OBFC1 | ENSP00000378161 | ENSP00000224950 | Acylphosphatase-2; Its physiological role is not yet clear | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...] | 0.670 |
| ACYP2 | RTEL1 | ENSP00000378161 | ENSP00000353332 | Acylphosphatase-2; Its physiological role is not yet clear | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] | 0.678 |
| ACYP2 | ZNF676 | ENSP00000378161 | ENSP00000380310 | Acylphosphatase-2; Its physiological role is not yet clear | Zinc finger protein 676; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.583 |
| CFAP57 | CTC1 | ENSP00000479773 | ENSP00000313759 | Cilia and flagella associated protein 57 | CST complex subunit CTC1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...] | 0.440 |
| CFAP57 | DHX35 | ENSP00000479773 | ENSP00000252011 | Cilia and flagella associated protein 57 | Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily | 0.549 |
| CFAP57 | ZNF676 | ENSP00000479773 | ENSP00000380310 | Cilia and flagella associated protein 57 | Zinc finger protein 676; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.565 |
| CTC1 | ACYP2 | ENSP00000313759 | ENSP00000378161 | CST complex subunit CTC1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...] | Acylphosphatase-2; Its physiological role is not yet clear | 0.630 |
| CTC1 | CFAP57 | ENSP00000313759 | ENSP00000479773 | CST complex subunit CTC1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...] | Cilia and flagella associated protein 57 | 0.440 |
| CTC1 | DCAF4 | ENSP00000313759 | ENSP00000351147 | CST complex subunit CTC1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...] | DDB1- and CUL4-associated factor 4; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors | 0.473 |
| CTC1 | OBFC1 | ENSP00000313759 | ENSP00000224950 | CST complex subunit CTC1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...] | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...] | 0.998 |
| CTC1 | RTEL1 | ENSP00000313759 | ENSP00000353332 | CST complex subunit CTC1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...] | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] | 0.897 |
| CTC1 | ZNF676 | ENSP00000313759 | ENSP00000380310 | CST complex subunit CTC1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...] | Zinc finger protein 676; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.715 |
| DCAF4 | CTC1 | ENSP00000351147 | ENSP00000313759 | DDB1- and CUL4-associated factor 4; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors | CST complex subunit CTC1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...] | 0.473 |
| DCAF4 | OBFC1 | ENSP00000351147 | ENSP00000224950 | DDB1- and CUL4-associated factor 4; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...] | 0.429 |
| DCAF4 | ZNF676 | ENSP00000351147 | ENSP00000380310 | DDB1- and CUL4-associated factor 4; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors | Zinc finger protein 676; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.582 |
| DHX35 | CFAP57 | ENSP00000252011 | ENSP00000479773 | Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily | Cilia and flagella associated protein 57 | 0.549 |
| DHX35 | ZNF676 | ENSP00000252011 | ENSP00000380310 | Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily | Zinc finger protein 676; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.516 |
| MBLAC1 | ZNF676 | ENSP00000381150 | ENSP00000380310 | Metallo-beta-lactamase domain containing 1 | Zinc finger protein 676; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.547 |
| OBFC1 | ACYP2 | ENSP00000224950 | ENSP00000378161 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...] | Acylphosphatase-2; Its physiological role is not yet clear | 0.670 |
