GPR146 protein (human) - STRING database

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GPR146

Probable G-protein coupled receptor 146; Orphan receptor; G protein-coupled receptors, Class A orphans (333 aa)

Predicted Functional Partners:

GPR139

0.788

KLHL35

0.722

DLEU7

0.710

ADAM30

0.707

GPR153

0.704

GPR83

0.693

CDH22

0.665

PSMG3

0.659

NPSR1

0.652

COX19

0.640

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM30	CDH22	ENSP00000358407	ENSP00000437790	Disintegrin and metalloproteinase domain-containing protein 30; Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation; ADAM metallopeptidase domain containing	Cadherin-22; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity)	0.588
ADAM30	DLEU7	ENSP00000358407	ENSP00000420976	Disintegrin and metalloproteinase domain-containing protein 30; Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation; ADAM metallopeptidase domain containing	Leukemia-associated protein 7; Deleted in lymphocytic leukemia, 7	0.665
ADAM30	GPR146	ENSP00000358407	ENSP00000380283	Disintegrin and metalloproteinase domain-containing protein 30; Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation; ADAM metallopeptidase domain containing	Probable G-protein coupled receptor 146; Orphan receptor; G protein-coupled receptors, Class A orphans	0.707
ADAM30	KLHL35	ENSP00000358407	ENSP00000438526	Disintegrin and metalloproteinase domain-containing protein 30; Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation; ADAM metallopeptidase domain containing	Kelch-like protein 35; Kelch like family member 35; BTB domain containing	0.716
CDH22	ADAM30	ENSP00000437790	ENSP00000358407	Cadherin-22; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity)	Disintegrin and metalloproteinase domain-containing protein 30; Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation; ADAM metallopeptidase domain containing	0.588
CDH22	DLEU7	ENSP00000437790	ENSP00000420976	Cadherin-22; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity)	Leukemia-associated protein 7; Deleted in lymphocytic leukemia, 7	0.624
CDH22	GPR146	ENSP00000437790	ENSP00000380283	Cadherin-22; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity)	Probable G-protein coupled receptor 146; Orphan receptor; G protein-coupled receptors, Class A orphans	0.665
CDH22	KLHL35	ENSP00000437790	ENSP00000438526	Cadherin-22; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity)	Kelch-like protein 35; Kelch like family member 35; BTB domain containing	0.700
COX19	GPR146	ENSP00000342015	ENSP00000380283	Cytochrome c oxidase assembly protein COX19; May be required for the assembly of mitochondrial cytochrome c oxidase; Mitochondrial respiratory chain complex assembly factors	Probable G-protein coupled receptor 146; Orphan receptor; G protein-coupled receptors, Class A orphans	0.640
COX19	PSMG3	ENSP00000342015	ENSP00000288607	Cytochrome c oxidase assembly protein COX19; May be required for the assembly of mitochondrial cytochrome c oxidase; Mitochondrial respiratory chain complex assembly factors	Proteasome assembly chaperone 3; Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes	0.658
DLEU7	ADAM30	ENSP00000420976	ENSP00000358407	Leukemia-associated protein 7; Deleted in lymphocytic leukemia, 7	Disintegrin and metalloproteinase domain-containing protein 30; Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation; ADAM metallopeptidase domain containing	0.665
DLEU7	CDH22	ENSP00000420976	ENSP00000437790	Leukemia-associated protein 7; Deleted in lymphocytic leukemia, 7	Cadherin-22; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity)	0.624
DLEU7	GPR146	ENSP00000420976	ENSP00000380283	Leukemia-associated protein 7; Deleted in lymphocytic leukemia, 7	Probable G-protein coupled receptor 146; Orphan receptor; G protein-coupled receptors, Class A orphans	0.710
DLEU7	KLHL35	ENSP00000420976	ENSP00000438526	Leukemia-associated protein 7; Deleted in lymphocytic leukemia, 7	Kelch-like protein 35; Kelch like family member 35; BTB domain containing	0.716
GPR139	GPR146	ENSP00000458791	ENSP00000380283	Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway; G protein-coupled receptors, Class A orphans	Probable G-protein coupled receptor 146; Orphan receptor; G protein-coupled receptors, Class A orphans	0.788
GPR139	GPR153	ENSP00000458791	ENSP00000367125	Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway; G protein-coupled receptors, Class A orphans	Probable G-protein coupled receptor 153; Orphan receptor; G protein-coupled receptors, Class A orphans	0.635
GPR139	GPR83	ENSP00000458791	ENSP00000243673	Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway; G protein-coupled receptors, Class A orphans	Probable G-protein coupled receptor 83; Orphan receptor. Could be a neuropeptide Y receptor; G protein-coupled receptors, Class A orphans	0.710
GPR139	NPSR1	ENSP00000458791	ENSP00000370950	Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway; G protein-coupled receptors, Class A orphans	Neuropeptide S receptor; G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE-mediated diseases	0.713
GPR146	ADAM30	ENSP00000380283	ENSP00000358407	Probable G-protein coupled receptor 146; Orphan receptor; G protein-coupled receptors, Class A orphans	Disintegrin and metalloproteinase domain-containing protein 30; Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation; ADAM metallopeptidase domain containing	0.707
GPR146	CDH22	ENSP00000380283	ENSP00000437790	Probable G-protein coupled receptor 146; Orphan receptor; G protein-coupled receptors, Class A orphans	Cadherin-22; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity)	0.665

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