| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARAF | TIMP1 | ENSP00000290277 | ENSP00000218388 | Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it [...] | 0.638 |
| ARAF | ZNF182 | ENSP00000290277 | ENSP00000380165 | Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily | Zinc finger protein 182; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.810 |
| DMRTB1 | ZNF182 | ENSP00000360500 | ENSP00000380165 | Doublesex- and mab-3-related transcription factor B1; DMRT like family B with proline rich C-terminal 1; Belongs to the DMRT family | Zinc finger protein 182; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.454 |
| ESR1 | TIMP1 | ENSP00000405330 | ENSP00000218388 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it [...] | 0.420 |
| ESR1 | ZNF182 | ENSP00000405330 | ENSP00000380165 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Zinc finger protein 182; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.422 |
| KIAA1456 | OR10H2 | ENSP00000432695 | ENSP00000306095 | Probable tRNA methyltransferase 9-like protein; May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9 | Olfactory receptor 10H2; Odorant receptor; Olfactory receptors, family 10 | 0.669 |
| KIAA1456 | ZNF182 | ENSP00000432695 | ENSP00000380165 | Probable tRNA methyltransferase 9-like protein; May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9 | Zinc finger protein 182; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.778 |
| OR10H2 | KIAA1456 | ENSP00000306095 | ENSP00000432695 | Olfactory receptor 10H2; Odorant receptor; Olfactory receptors, family 10 | Probable tRNA methyltransferase 9-like protein; May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9 | 0.669 |
| OR10H2 | ZNF182 | ENSP00000306095 | ENSP00000380165 | Olfactory receptor 10H2; Odorant receptor; Olfactory receptors, family 10 | Zinc finger protein 182; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.655 |
| SPACA5 | ZNF182 | ENSP00000305847 | ENSP00000380165 | Sperm acrosome associated 5; Belongs to the glycosyl hydrolase 22 family | Zinc finger protein 182; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.571 |
| SPACA5B | ZNF182 | ENSP00000304762 | ENSP00000380165 | Sperm acrosome associated 5B; Lysozymes, c-type | Zinc finger protein 182; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.580 |
| TBC1D25 | TIMP1 | ENSP00000365962 | ENSP00000218388 | TBC1 domain family member 25; Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it [...] | 0.538 |
| TBC1D25 | WDR13 | ENSP00000365962 | ENSP00000365919 | TBC1 domain family member 25; Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes | WD repeat-containing protein 13; WD repeat domain containing | 0.473 |
| TBC1D25 | ZNF182 | ENSP00000365962 | ENSP00000380165 | TBC1 domain family member 25; Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes | Zinc finger protein 182; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.679 |
| TIMP1 | ARAF | ENSP00000218388 | ENSP00000290277 | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it [...] | Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily | 0.638 |
| TIMP1 | ESR1 | ENSP00000218388 | ENSP00000405330 | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it [...] | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | 0.420 |
| TIMP1 | TBC1D25 | ENSP00000218388 | ENSP00000365962 | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it [...] | TBC1 domain family member 25; Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes | 0.538 |
| TIMP1 | ZNF182 | ENSP00000218388 | ENSP00000380165 | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it [...] | Zinc finger protein 182; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.641 |
| WDR13 | TBC1D25 | ENSP00000365919 | ENSP00000365962 | WD repeat-containing protein 13; WD repeat domain containing | TBC1 domain family member 25; Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes | 0.473 |
| WDR13 | ZNF182 | ENSP00000365919 | ENSP00000380165 | WD repeat-containing protein 13; WD repeat domain containing | Zinc finger protein 182; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.548 |
