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  • 11.0 [archived version]
STRINGSTRING
RXRB RXRB TBC1D23 TBC1D23 S100PBP S100PBP FLYWCH2 FLYWCH2 RSC1A1 RSC1A1 WDR90 WDR90 ZNF720 ZNF720 C16orf52 C16orf52 FAM86C1 FAM86C1 MRPL37 MRPL37 HENMT1 HENMT1
"FLYWCH2" - FLYWCH family member 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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[Homology]
Score
FLYWCH2FLYWCH family member 2 (140 aa)    
Predicted Functional Partners:
C16orf52
Uncharacterized protein C16orf52; Chromosome 16 open reading frame 52 (167 aa)
           
  0.642
TBC1D23
TBC1 domain family member 23; Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth (By similarity). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but inste [...] (699 aa)
       
      0.638
ZNF720
Putative protein ZNF720; Zinc finger protein 720; Zinc fingers C2H2-type (126 aa)
           
  0.634
FAM86C1
Protein FAM86C1; Family with sequence similarity 86 member C1 (165 aa)
           
  0.560
RSC1A1
Regulatory solute carrier protein family 1 member 1; Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network (617 aa)
           
  0.556
WDR90
WD repeat-containing protein 90; WD repeat domain containing (1748 aa)
           
  0.556
RXRB
Retinoic acid receptor RXR-beta; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE); Nuclear hormone receptors (537 aa)
       
      0.527
S100PBP
S100P binding protein (408 aa)
           
  0.510
HENMT1
Small RNA 2’-O-methyltransferase; Methyltransferase that adds a 2’-O-methyl group at the 3’-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3’-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis; Seven-beta-strand methyltransferase motif containing (393 aa)
           
  0.510
MRPL37
Mitochondrial ribosomal protein L37; Belongs to the mitochondrion-specific ribosomal protein mL37 family (423 aa)
           
  0.491
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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