RBAK protein (human) - STRING database

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RBAK

RB-associated KRAB zinc finger protein; May repress E2F-dependent transcription. May promote AR- dependent transcription; Belongs to the krueppel C2H2-type zinc-finger protein family (714 aa)

Predicted Functional Partners:

ZNF121

0.704

FAM19A5

0.566

RB1

0.559

AR

0.487

SPATA20

0.446

NT5C

0.433

UPF3B

0.423

ZFYVE26

0.403

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	RB1	ENSP00000363822	ENSP00000267163	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3	Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransfer [...]	0.963
AR	RBAK	ENSP00000363822	ENSP00000380120	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3	RB-associated KRAB zinc finger protein; May repress E2F-dependent transcription. May promote AR- dependent transcription; Belongs to the krueppel C2H2-type zinc-finger protein family	0.487
FAM19A5	RBAK	ENSP00000383933	ENSP00000380120	Protein FAM19A5; Family with sequence similarity 19 member A5, C-C motif chemokine like; Belongs to the FAM19/TAFA family	RB-associated KRAB zinc finger protein; May repress E2F-dependent transcription. May promote AR- dependent transcription; Belongs to the krueppel C2H2-type zinc-finger protein family	0.566
NT5C	RBAK	ENSP00000245552	ENSP00000380120	5’(3’)-deoxyribonucleotidase, cytosolic type; Dephosphorylates the 5’ and 2’(3’)-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP; Belongs to the 5’(3’)-deoxyribonucleotidase family	RB-associated KRAB zinc finger protein; May repress E2F-dependent transcription. May promote AR- dependent transcription; Belongs to the krueppel C2H2-type zinc-finger protein family	0.433
RB1	AR	ENSP00000267163	ENSP00000363822	Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransfer [...]	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3	0.963
RB1	RBAK	ENSP00000267163	ENSP00000380120	Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransfer [...]	RB-associated KRAB zinc finger protein; May repress E2F-dependent transcription. May promote AR- dependent transcription; Belongs to the krueppel C2H2-type zinc-finger protein family	0.559
RBAK	AR	ENSP00000380120	ENSP00000363822	RB-associated KRAB zinc finger protein; May repress E2F-dependent transcription. May promote AR- dependent transcription; Belongs to the krueppel C2H2-type zinc-finger protein family	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3	0.487
RBAK	FAM19A5	ENSP00000380120	ENSP00000383933	RB-associated KRAB zinc finger protein; May repress E2F-dependent transcription. May promote AR- dependent transcription; Belongs to the krueppel C2H2-type zinc-finger protein family	Protein FAM19A5; Family with sequence similarity 19 member A5, C-C motif chemokine like; Belongs to the FAM19/TAFA family	0.566
RBAK	NT5C	ENSP00000380120	ENSP00000245552	RB-associated KRAB zinc finger protein; May repress E2F-dependent transcription. May promote AR- dependent transcription; Belongs to the krueppel C2H2-type zinc-finger protein family	5’(3’)-deoxyribonucleotidase, cytosolic type; Dephosphorylates the 5’ and 2’(3’)-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP; Belongs to the 5’(3’)-deoxyribonucleotidase family	0.433
RBAK	RB1	ENSP00000380120	ENSP00000267163	RB-associated KRAB zinc finger protein; May repress E2F-dependent transcription. May promote AR- dependent transcription; Belongs to the krueppel C2H2-type zinc-finger protein family	Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransfer [...]	0.559
RBAK	SPATA20	ENSP00000380120	ENSP00000006658	RB-associated KRAB zinc finger protein; May repress E2F-dependent transcription. May promote AR- dependent transcription; Belongs to the krueppel C2H2-type zinc-finger protein family	Spermatogenesis-associated protein 20; May play a role in fertility regulation	0.446
RBAK	UPF3B	ENSP00000380120	ENSP00000276201	RB-associated KRAB zinc finger protein; May repress E2F-dependent transcription. May promote AR- dependent transcription; Belongs to the krueppel C2H2-type zinc-finger protein family	Regulator of nonsense transcripts 3B; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2- UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon- [...]	0.423
RBAK	ZFYVE26	ENSP00000380120	ENSP00000251119	RB-associated KRAB zinc finger protein; May repress E2F-dependent transcription. May promote AR- dependent transcription; Belongs to the krueppel C2H2-type zinc-finger protein family	Zinc finger FYVE domain-containing protein 26; Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis- recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair; Zinc fingers FYVE-type	0.403
RBAK	ZNF121	ENSP00000380120	ENSP00000326967	RB-associated KRAB zinc finger protein; May repress E2F-dependent transcription. May promote AR- dependent transcription; Belongs to the krueppel C2H2-type zinc-finger protein family	Zinc finger protein 121; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.704
SPATA20	RBAK	ENSP00000006658	ENSP00000380120	Spermatogenesis-associated protein 20; May play a role in fertility regulation	RB-associated KRAB zinc finger protein; May repress E2F-dependent transcription. May promote AR- dependent transcription; Belongs to the krueppel C2H2-type zinc-finger protein family	0.446
UPF3B	RBAK	ENSP00000276201	ENSP00000380120	Regulator of nonsense transcripts 3B; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2- UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon- [...]	RB-associated KRAB zinc finger protein; May repress E2F-dependent transcription. May promote AR- dependent transcription; Belongs to the krueppel C2H2-type zinc-finger protein family	0.423
ZFYVE26	RBAK	ENSP00000251119	ENSP00000380120	Zinc finger FYVE domain-containing protein 26; Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis- recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair; Zinc fingers FYVE-type	RB-associated KRAB zinc finger protein; May repress E2F-dependent transcription. May promote AR- dependent transcription; Belongs to the krueppel C2H2-type zinc-finger protein family	0.403
ZNF121	RBAK	ENSP00000326967	ENSP00000380120	Zinc finger protein 121; May be involved in transcriptional regulation; Zinc fingers C2H2-type	RB-associated KRAB zinc finger protein; May repress E2F-dependent transcription. May promote AR- dependent transcription; Belongs to the krueppel C2H2-type zinc-finger protein family	0.704

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