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STRINGSTRING
BCL7C BCL7C BCL7B BCL7B SS18 SS18 SS18L1 SS18L1 BCL7A BCL7A SMARCD1 SMARCD1 GLTSCR1 GLTSCR1 SYMPK SYMPK GLTSCR2 GLTSCR2 WHSC1L1 WHSC1L1 ATAD5 ATAD5
"GLTSCR1" - BRD4-interacting chromatin-remodeling complex-associated protein in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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GLTSCR1BRD4-interacting chromatin-remodeling complex-associated protein; May play a role in BRD4-mediated gene transcription (1560 aa)    
Predicted Functional Partners:
SS18
Protein SSXT; Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation; BAF complex (418 aa)
        
 
  0.954
BCL7C
B-cell CLL/lymphoma 7 protein family member C; May play an anti-apoptotic role; BAF complex (242 aa)
        
 
  0.947
BCL7A
B-cell CLL/lymphoma 7 protein family member A; BCL tumor suppressor 7A; BAF complex (231 aa)
        
 
  0.927
BCL7B
B-cell CLL/lymphoma 7 protein family member B; Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1. Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation. May play a role in lung tumor development or progression (By similarity); Belongs to the BCL7 family (213 aa)
            
  0.770
SS18L1
Calcium-responsive transactivator; Transcriptional activator which is required for calcium- dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is depho [...] (396 aa)
            
  0.757
SMARCD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). Du [...] (515 aa)
        
 
  0.722
GLTSCR2
Ribosome biogenesis protein NOP53; Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may also play a role in rRNA transcription. Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 acti [...] (478 aa)
            
  0.715
SYMPK
Symplekin; Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3’-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house- keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity; Belongs to the Symplekin family (1274 aa)
      
   
  0.595
WHSC1L1
Histone-lysine N-methyltransferase NSD3; Histone methyltransferase. Preferentially methylates ’Lys-4’ and ’Lys-27’ of histone H3. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation, while ’Lys-27’ is a mark for transcriptional repression (1437 aa)
      
   
  0.592
ATAD5
ATPase family AAA domain-containing protein 5; Involved in DNA damage response. Involved in a RAD9A- related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages- induced apoptosis; AAA ATPases (1844 aa)
            
  0.550
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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