node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKMY1 | ZDHHC4 | ENSP00000385887 | ENSP00000379934 | Ankyrin repeat and MYND domain containing 1 | Probable palmitoyltransferase ZDHHC4; Zinc finger DHHC-type containing 4; Belongs to the DHHC palmitoyltransferase family | 0.475 |
AWAT2 | ZDHHC4 | ENSP00000421172 | ENSP00000379934 | Acyl-CoA wax alcohol acyltransferase 2; Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has no activity using decyl alcohol and significantly prefers the C16 and C18 alcohols. May also have 2-acylglycerol O-acyltransferase (MGAT) and acyl- CoA-retinol acyltransferase (ARAT) activities, to catalyze the synthesis of diacylglycerols and retinyl esters; however this activity is unclear in vivo | Probable palmitoyltransferase ZDHHC4; Zinc finger DHHC-type containing 4; Belongs to the DHHC palmitoyltransferase family | 0.676 |
MSANTD4 | ZDHHC4 | ENSP00000304713 | ENSP00000379934 | Myb/SANT-like DNA-binding domain-containing protein 4; Myb/SANT DNA binding domain containing 4 with coiled-coils | Probable palmitoyltransferase ZDHHC4; Zinc finger DHHC-type containing 4; Belongs to the DHHC palmitoyltransferase family | 0.440 |
PRG4 | ZDHHC4 | ENSP00000399679 | ENSP00000379934 | Proteoglycan 4; Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface | Probable palmitoyltransferase ZDHHC4; Zinc finger DHHC-type containing 4; Belongs to the DHHC palmitoyltransferase family | 0.495 |
REG1A | ZDHHC4 | ENSP00000233735 | ENSP00000379934 | Lithostathine-1-alpha; Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration; C-type lectin domain containing | Probable palmitoyltransferase ZDHHC4; Zinc finger DHHC-type containing 4; Belongs to the DHHC palmitoyltransferase family | 0.450 |
SMAD3 | ZDHHC4 | ENSP00000332973 | ENSP00000379934 | Mothers against decapentaplegic homolog 3; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and mi [...] | Probable palmitoyltransferase ZDHHC4; Zinc finger DHHC-type containing 4; Belongs to the DHHC palmitoyltransferase family | 0.544 |
STX10 | STX6 | ENSP00000466298 | ENSP00000258301 | Syntaxin-10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network; Belongs to the syntaxin family | Syntaxin-6; Involved in intracellular vesicle trafficking; Syntaxins | 0.936 |
STX10 | ZDHHC4 | ENSP00000466298 | ENSP00000379934 | Syntaxin-10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network; Belongs to the syntaxin family | Probable palmitoyltransferase ZDHHC4; Zinc finger DHHC-type containing 4; Belongs to the DHHC palmitoyltransferase family | 0.463 |
STX6 | STX10 | ENSP00000258301 | ENSP00000466298 | Syntaxin-6; Involved in intracellular vesicle trafficking; Syntaxins | Syntaxin-10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network; Belongs to the syntaxin family | 0.936 |
STX6 | ZDHHC4 | ENSP00000258301 | ENSP00000379934 | Syntaxin-6; Involved in intracellular vesicle trafficking; Syntaxins | Probable palmitoyltransferase ZDHHC4; Zinc finger DHHC-type containing 4; Belongs to the DHHC palmitoyltransferase family | 0.463 |
ZDHHC22 | ZDHHC4 | ENSP00000318222 | ENSP00000379934 | Palmitoyltransferase ZDHHC22; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane; Zinc fingers DHHC-type | Probable palmitoyltransferase ZDHHC4; Zinc finger DHHC-type containing 4; Belongs to the DHHC palmitoyltransferase family | 0.753 |
ZDHHC4 | ANKMY1 | ENSP00000379934 | ENSP00000385887 | Probable palmitoyltransferase ZDHHC4; Zinc finger DHHC-type containing 4; Belongs to the DHHC palmitoyltransferase family | Ankyrin repeat and MYND domain containing 1 | 0.475 |
ZDHHC4 | AWAT2 | ENSP00000379934 | ENSP00000421172 | Probable palmitoyltransferase ZDHHC4; Zinc finger DHHC-type containing 4; Belongs to the DHHC palmitoyltransferase family | Acyl-CoA wax alcohol acyltransferase 2; Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has no activity using decyl alcohol and significantly prefers the C16 and C18 alcohols. May also have 2-acylglycerol O-acyltransferase (MGAT) and acyl- CoA-retinol acyltransferase (ARAT) activities, to catalyze the synthesis of diacylglycerols and retinyl esters; however this activity is unclear in vivo | 0.676 |
ZDHHC4 | MSANTD4 | ENSP00000379934 | ENSP00000304713 | Probable palmitoyltransferase ZDHHC4; Zinc finger DHHC-type containing 4; Belongs to the DHHC palmitoyltransferase family | Myb/SANT-like DNA-binding domain-containing protein 4; Myb/SANT DNA binding domain containing 4 with coiled-coils | 0.440 |
ZDHHC4 | PRG4 | ENSP00000379934 | ENSP00000399679 | Probable palmitoyltransferase ZDHHC4; Zinc finger DHHC-type containing 4; Belongs to the DHHC palmitoyltransferase family | Proteoglycan 4; Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface | 0.495 |
ZDHHC4 | REG1A | ENSP00000379934 | ENSP00000233735 | Probable palmitoyltransferase ZDHHC4; Zinc finger DHHC-type containing 4; Belongs to the DHHC palmitoyltransferase family | Lithostathine-1-alpha; Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration; C-type lectin domain containing | 0.450 |
ZDHHC4 | SMAD3 | ENSP00000379934 | ENSP00000332973 | Probable palmitoyltransferase ZDHHC4; Zinc finger DHHC-type containing 4; Belongs to the DHHC palmitoyltransferase family | Mothers against decapentaplegic homolog 3; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and mi [...] | 0.544 |
ZDHHC4 | STX10 | ENSP00000379934 | ENSP00000466298 | Probable palmitoyltransferase ZDHHC4; Zinc finger DHHC-type containing 4; Belongs to the DHHC palmitoyltransferase family | Syntaxin-10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network; Belongs to the syntaxin family | 0.463 |
ZDHHC4 | STX6 | ENSP00000379934 | ENSP00000258301 | Probable palmitoyltransferase ZDHHC4; Zinc finger DHHC-type containing 4; Belongs to the DHHC palmitoyltransferase family | Syntaxin-6; Involved in intracellular vesicle trafficking; Syntaxins | 0.463 |
ZDHHC4 | ZDHHC22 | ENSP00000379934 | ENSP00000318222 | Probable palmitoyltransferase ZDHHC4; Zinc finger DHHC-type containing 4; Belongs to the DHHC palmitoyltransferase family | Palmitoyltransferase ZDHHC22; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane; Zinc fingers DHHC-type | 0.753 |