| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BCHE | COCH | ENSP00000264381 | ENSP00000379862 | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters; Belongs to the type-B carboxylesterase/lipase family | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork; Deafness associated genes | 0.774 |
| COCH | BCHE | ENSP00000379862 | ENSP00000264381 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork; Deafness associated genes | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters; Belongs to the type-B carboxylesterase/lipase family | 0.774 |
| COCH | DFNA5 | ENSP00000379862 | ENSP00000339587 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork; Deafness associated genes | Gasdermin-E; Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | 0.654 |
| COCH | GHR | ENSP00000379862 | ENSP00000483403 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork; Deafness associated genes | Growth hormone receptor; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity); Belongs to the type I cytokine receptor family. Type 1 subfamily | 0.634 |
| COCH | GJB3 | ENSP00000379862 | ENSP00000362464 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork; Deafness associated genes | Gap junction beta-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Deafness associated genes | 0.731 |
| COCH | KCNQ4 | ENSP00000379862 | ENSP00000262916 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork; Deafness associated genes | Potassium voltage-gated channel subfamily KQT member 4; Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors; Deafness associated genes | 0.706 |
| COCH | SLC22A17 | ENSP00000379862 | ENSP00000380437 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork; Deafness associated genes | Solute carrier family 22 member 17; Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resul [...] | 0.800 |
| COCH | SLC26A4 | ENSP00000379862 | ENSP00000265715 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork; Deafness associated genes | Pendrin; Sodium-independent transporter of chloride and iodide; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family | 0.642 |
| COCH | SLC44A2 | ENSP00000379862 | ENSP00000336888 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork; Deafness associated genes | Choline transporter-like protein 2; Isoform 1, but not isoform 3, exhibits some choline transporter activity; Solute carriers | 0.671 |
| COCH | STXBP6 | ENSP00000379862 | ENSP00000324302 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork; Deafness associated genes | Syntaxin-binding protein 6; Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis | 0.800 |
| COCH | TECTB | ENSP00000379862 | ENSP00000358430 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork; Deafness associated genes | Beta-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals | 0.755 |
| DFNA5 | COCH | ENSP00000339587 | ENSP00000379862 | Gasdermin-E; Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork; Deafness associated genes | 0.654 |
| DFNA5 | GJB3 | ENSP00000339587 | ENSP00000362464 | Gasdermin-E; Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | Gap junction beta-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Deafness associated genes | 0.476 |
| DFNA5 | KCNQ4 | ENSP00000339587 | ENSP00000262916 | Gasdermin-E; Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | Potassium voltage-gated channel subfamily KQT member 4; Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors; Deafness associated genes | 0.692 |
| DFNA5 | SLC26A4 | ENSP00000339587 | ENSP00000265715 | Gasdermin-E; Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | Pendrin; Sodium-independent transporter of chloride and iodide; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family | 0.477 |
| GHR | COCH | ENSP00000483403 | ENSP00000379862 | Growth hormone receptor; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity); Belongs to the type I cytokine receptor family. Type 1 subfamily | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork; Deafness associated genes | 0.634 |
| GJB3 | COCH | ENSP00000362464 | ENSP00000379862 | Gap junction beta-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Deafness associated genes | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork; Deafness associated genes | 0.731 |
| GJB3 | DFNA5 | ENSP00000362464 | ENSP00000339587 | Gap junction beta-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Deafness associated genes | Gasdermin-E; Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 | 0.476 |
| GJB3 | KCNQ4 | ENSP00000362464 | ENSP00000262916 | Gap junction beta-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Deafness associated genes | Potassium voltage-gated channel subfamily KQT member 4; Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors; Deafness associated genes | 0.800 |
| GJB3 | SLC26A4 | ENSP00000362464 | ENSP00000265715 | Gap junction beta-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Deafness associated genes | Pendrin; Sodium-independent transporter of chloride and iodide; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family | 0.791 |
