| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CXorf67 | MBTD1 | ENSP00000342680 | ENSP00000468304 | Uncharacterized protein CXorf67; Chromosome X open reading frame 67 | MBT domain-containing protein 1; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Specifically binds to monomethylated and dimethylated ’Lys-20’ on histone H4; MBT domain containing | 0.736 |
| CXorf67 | MEAF6 | ENSP00000342680 | ENSP00000362166 | Uncharacterized protein CXorf67; Chromosome X open reading frame 67 | Chromatin modification-related protein MEAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in viv [...] | 0.706 |
| CXorf67 | NUTM2A | ENSP00000342680 | ENSP00000371126 | Uncharacterized protein CXorf67; Chromosome X open reading frame 67 | NUT family member 2A | 0.700 |
| CXorf67 | ZC3H7A | ENSP00000342680 | ENSP00000379773 | Uncharacterized protein CXorf67; Chromosome X open reading frame 67 | Zinc finger CCCH domain-containing protein 7A; May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3’-ATA(A/T)-5’ motif in the apical loop; Tetratricopeptide repeat domain containing | 0.672 |
| MBTD1 | CXorf67 | ENSP00000468304 | ENSP00000342680 | MBT domain-containing protein 1; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Specifically binds to monomethylated and dimethylated ’Lys-20’ on histone H4; MBT domain containing | Uncharacterized protein CXorf67; Chromosome X open reading frame 67 | 0.736 |
| MBTD1 | MEAF6 | ENSP00000468304 | ENSP00000362166 | MBT domain-containing protein 1; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Specifically binds to monomethylated and dimethylated ’Lys-20’ on histone H4; MBT domain containing | Chromatin modification-related protein MEAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in viv [...] | 0.938 |
| MBTD1 | NUTM2A | ENSP00000468304 | ENSP00000371126 | MBT domain-containing protein 1; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Specifically binds to monomethylated and dimethylated ’Lys-20’ on histone H4; MBT domain containing | NUT family member 2A | 0.567 |
| MBTD1 | ZC3H7A | ENSP00000468304 | ENSP00000379773 | MBT domain-containing protein 1; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Specifically binds to monomethylated and dimethylated ’Lys-20’ on histone H4; MBT domain containing | Zinc finger CCCH domain-containing protein 7A; May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3’-ATA(A/T)-5’ motif in the apical loop; Tetratricopeptide repeat domain containing | 0.559 |
| MEAF6 | CXorf67 | ENSP00000362166 | ENSP00000342680 | Chromatin modification-related protein MEAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in viv [...] | Uncharacterized protein CXorf67; Chromosome X open reading frame 67 | 0.706 |
| MEAF6 | MBTD1 | ENSP00000362166 | ENSP00000468304 | Chromatin modification-related protein MEAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in viv [...] | MBT domain-containing protein 1; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Specifically binds to monomethylated and dimethylated ’Lys-20’ on histone H4; MBT domain containing | 0.938 |
| MEAF6 | NUTM2A | ENSP00000362166 | ENSP00000371126 | Chromatin modification-related protein MEAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in viv [...] | NUT family member 2A | 0.603 |
| MEAF6 | ZC3H7A | ENSP00000362166 | ENSP00000379773 | Chromatin modification-related protein MEAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in viv [...] | Zinc finger CCCH domain-containing protein 7A; May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3’-ATA(A/T)-5’ motif in the apical loop; Tetratricopeptide repeat domain containing | 0.579 |
| MKRN1 | ZC3H7A | ENSP00000255977 | ENSP00000379773 | E3 ubiquitin-protein ligase makorin-1; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription; Ring finger proteins | Zinc finger CCCH domain-containing protein 7A; May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3’-ATA(A/T)-5’ motif in the apical loop; Tetratricopeptide repeat domain containing | 0.632 |
| NUTM2A | CXorf67 | ENSP00000371126 | ENSP00000342680 | NUT family member 2A | Uncharacterized protein CXorf67; Chromosome X open reading frame 67 | 0.700 |
| NUTM2A | MBTD1 | ENSP00000371126 | ENSP00000468304 | NUT family member 2A | MBT domain-containing protein 1; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Specifically binds to monomethylated and dimethylated ’Lys-20’ on histone H4; MBT domain containing | 0.567 |
| NUTM2A | MEAF6 | ENSP00000371126 | ENSP00000362166 | NUT family member 2A | Chromatin modification-related protein MEAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in viv [...] | 0.603 |
| NUTM2A | ZC3H7A | ENSP00000371126 | ENSP00000379773 | NUT family member 2A | Zinc finger CCCH domain-containing protein 7A; May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3’-ATA(A/T)-5’ motif in the apical loop; Tetratricopeptide repeat domain containing | 0.629 |
| RBM26 | ZC3H12B | ENSP00000483408 | ENSP00000340839 | RNA-binding protein 26; Protein phosphatase 1 regulatory subunits | Probable ribonuclease ZC3H12B; May function as RNase and regulate the levels of target RNA species; Zinc fingers CCCH-type | 0.598 |
| RBM26 | ZC3H15 | ENSP00000483408 | ENSP00000338788 | RNA-binding protein 26; Protein phosphatase 1 regulatory subunits | Zinc finger CCCH domain-containing protein 15; Protects DRG1 from proteolytic degradation; Zinc fingers CCCH-type | 0.625 |
| RBM26 | ZC3H4 | ENSP00000483408 | ENSP00000253048 | RNA-binding protein 26; Protein phosphatase 1 regulatory subunits | Zinc finger CCCH domain-containing protein 4; Armadillo-like helical domain containing | 0.634 |
