| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMELX | C4orf26 | ENSP00000370088 | ENSP00000406925 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Odontogenesis associated phosphoprotein; May promote nucleation of hydroxyapatite | 0.669 |
| AMELX | DLX3 | ENSP00000370088 | ENSP00000389870 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Homeobox protein DLX-3; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis; Belongs to the distal-less homeobox family | 0.572 |
| AMELX | ENAM | ENSP00000370088 | ENSP00000379383 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation | 0.995 |
| AMELX | FAM83H | ENSP00000370088 | ENSP00000373565 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Protein FAM83H; May play a major role in the structural organization and calcification of developing enamel. May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration | 0.790 |
| AMELX | KLK4 | ENSP00000370088 | ENSP00000326159 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Kallikrein-4; Has a major role in enamel formation. Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity); Kallikreins | 0.803 |
| AMELX | MMP20 | ENSP00000370088 | ENSP00000260228 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix- aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the ’360-Asn-|-Phe-361’ site; M10 matrix metallopeptidases | 0.921 |
| AMELX | SLC24A4 | ENSP00000370088 | ENSP00000431840 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Sodium/potassium/calcium exchanger 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis (By similarity); Belongs to the Ca(2+)-cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily | 0.518 |
| AMELX | WDR72 | ENSP00000370088 | ENSP00000379619 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | WD repeat-containing protein 72; Plays a major role in formation of tooth enamel. Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane; WD repeat domain containing | 0.760 |
| C4orf26 | AMELX | ENSP00000406925 | ENSP00000370088 | Odontogenesis associated phosphoprotein; May promote nucleation of hydroxyapatite | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | 0.669 |
| C4orf26 | DLX3 | ENSP00000406925 | ENSP00000389870 | Odontogenesis associated phosphoprotein; May promote nucleation of hydroxyapatite | Homeobox protein DLX-3; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis; Belongs to the distal-less homeobox family | 0.451 |
| C4orf26 | ENAM | ENSP00000406925 | ENSP00000379383 | Odontogenesis associated phosphoprotein; May promote nucleation of hydroxyapatite | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation | 0.720 |
| C4orf26 | FAM83H | ENSP00000406925 | ENSP00000373565 | Odontogenesis associated phosphoprotein; May promote nucleation of hydroxyapatite | Protein FAM83H; May play a major role in the structural organization and calcification of developing enamel. May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration | 0.790 |
| C4orf26 | KLK4 | ENSP00000406925 | ENSP00000326159 | Odontogenesis associated phosphoprotein; May promote nucleation of hydroxyapatite | Kallikrein-4; Has a major role in enamel formation. Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity); Kallikreins | 0.583 |
| C4orf26 | MMP20 | ENSP00000406925 | ENSP00000260228 | Odontogenesis associated phosphoprotein; May promote nucleation of hydroxyapatite | Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix- aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the ’360-Asn-|-Phe-361’ site; M10 matrix metallopeptidases | 0.710 |
| C4orf26 | SLC24A4 | ENSP00000406925 | ENSP00000431840 | Odontogenesis associated phosphoprotein; May promote nucleation of hydroxyapatite | Sodium/potassium/calcium exchanger 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis (By similarity); Belongs to the Ca(2+)-cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily | 0.670 |
| C4orf26 | WDR72 | ENSP00000406925 | ENSP00000379619 | Odontogenesis associated phosphoprotein; May promote nucleation of hydroxyapatite | WD repeat-containing protein 72; Plays a major role in formation of tooth enamel. Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane; WD repeat domain containing | 0.794 |
| DLX3 | AMELX | ENSP00000389870 | ENSP00000370088 | Homeobox protein DLX-3; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis; Belongs to the distal-less homeobox family | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | 0.572 |
| DLX3 | C4orf26 | ENSP00000389870 | ENSP00000406925 | Homeobox protein DLX-3; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis; Belongs to the distal-less homeobox family | Odontogenesis associated phosphoprotein; May promote nucleation of hydroxyapatite | 0.451 |
| DLX3 | ENAM | ENSP00000389870 | ENSP00000379383 | Homeobox protein DLX-3; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis; Belongs to the distal-less homeobox family | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation | 0.634 |
| DLX3 | FAM83H | ENSP00000389870 | ENSP00000373565 | Homeobox protein DLX-3; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis; Belongs to the distal-less homeobox family | Protein FAM83H; May play a major role in the structural organization and calcification of developing enamel. May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration | 0.619 |
