| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCDC137 | MRGPRX3 | ENSP00000329360 | ENSP00000379571 | Coiled-coil domain containing 137 | Mas-related G-protein coupled receptor member X3; Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity); G protein-coupled receptors, Class A orphans | 0.516 |
| CCDC137 | TMEM69 | ENSP00000329360 | ENSP00000361095 | Coiled-coil domain containing 137 | Transmembrane protein 69 | 0.630 |
| GPR42 | MRGPRX3 | ENSP00000473212 | ENSP00000379571 | G-protein coupled receptor 42; Probable G protein-coupled receptor that may be activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that may play a role in the regulation of whole-body energy homeostasis and/or in intestinal immunity | Mas-related G-protein coupled receptor member X3; Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity); G protein-coupled receptors, Class A orphans | 0.473 |
| MORF4L2 | MRGPRX3 | ENSP00000394417 | ENSP00000379571 | Mortality factor 4-like protein 2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative [...] | Mas-related G-protein coupled receptor member X3; Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity); G protein-coupled receptors, Class A orphans | 0.462 |
| MRGPRX3 | CCDC137 | ENSP00000379571 | ENSP00000329360 | Mas-related G-protein coupled receptor member X3; Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity); G protein-coupled receptors, Class A orphans | Coiled-coil domain containing 137 | 0.516 |
| MRGPRX3 | GPR42 | ENSP00000379571 | ENSP00000473212 | Mas-related G-protein coupled receptor member X3; Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity); G protein-coupled receptors, Class A orphans | G-protein coupled receptor 42; Probable G protein-coupled receptor that may be activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that may play a role in the regulation of whole-body energy homeostasis and/or in intestinal immunity | 0.473 |
| MRGPRX3 | MORF4L2 | ENSP00000379571 | ENSP00000394417 | Mas-related G-protein coupled receptor member X3; Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity); G protein-coupled receptors, Class A orphans | Mortality factor 4-like protein 2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative [...] | 0.462 |
| MRGPRX3 | NMB | ENSP00000379571 | ENSP00000378089 | Mas-related G-protein coupled receptor member X3; Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity); G protein-coupled receptors, Class A orphans | Neuromedin-B; Stimulates smooth muscle contraction in a manner similar to that of bombesin; Belongs to the bombesin/neuromedin-B/ranatensin family | 0.406 |
| MRGPRX3 | NPFF | ENSP00000379571 | ENSP00000267017 | Mas-related G-protein coupled receptor member X3; Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity); G protein-coupled receptors, Class A orphans | Pro-FMRFamide-related neuropeptide FF; Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels; Endogenous ligands | 0.754 |
| MRGPRX3 | NPS | ENSP00000379571 | ENSP00000381105 | Mas-related G-protein coupled receptor member X3; Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity); G protein-coupled receptors, Class A orphans | Neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations; Endogenous ligands | 0.540 |
| MRGPRX3 | STK19 | ENSP00000379571 | ENSP00000364482 | Mas-related G-protein coupled receptor member X3; Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity); G protein-coupled receptors, Class A orphans | Serine/threonine-protein kinase 19; Seems to be a protein kinase. In vitro it can phosphorylate casein-alpha on serine and threonine residues and histones on serine residues | 0.469 |
| MRGPRX3 | TMEM69 | ENSP00000379571 | ENSP00000361095 | Mas-related G-protein coupled receptor member X3; Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity); G protein-coupled receptors, Class A orphans | Transmembrane protein 69 | 0.450 |
| NMB | MRGPRX3 | ENSP00000378089 | ENSP00000379571 | Neuromedin-B; Stimulates smooth muscle contraction in a manner similar to that of bombesin; Belongs to the bombesin/neuromedin-B/ranatensin family | Mas-related G-protein coupled receptor member X3; Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity); G protein-coupled receptors, Class A orphans | 0.406 |
| NMB | NPFF | ENSP00000378089 | ENSP00000267017 | Neuromedin-B; Stimulates smooth muscle contraction in a manner similar to that of bombesin; Belongs to the bombesin/neuromedin-B/ranatensin family | Pro-FMRFamide-related neuropeptide FF; Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels; Endogenous ligands | 0.926 |
| NMB | NPS | ENSP00000378089 | ENSP00000381105 | Neuromedin-B; Stimulates smooth muscle contraction in a manner similar to that of bombesin; Belongs to the bombesin/neuromedin-B/ranatensin family | Neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations; Endogenous ligands | 0.956 |
| NPFF | MRGPRX3 | ENSP00000267017 | ENSP00000379571 | Pro-FMRFamide-related neuropeptide FF; Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels; Endogenous ligands | Mas-related G-protein coupled receptor member X3; Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity); G protein-coupled receptors, Class A orphans | 0.754 |
| NPFF | NMB | ENSP00000267017 | ENSP00000378089 | Pro-FMRFamide-related neuropeptide FF; Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels; Endogenous ligands | Neuromedin-B; Stimulates smooth muscle contraction in a manner similar to that of bombesin; Belongs to the bombesin/neuromedin-B/ranatensin family | 0.926 |
| NPFF | NPS | ENSP00000267017 | ENSP00000381105 | Pro-FMRFamide-related neuropeptide FF; Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels; Endogenous ligands | Neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations; Endogenous ligands | 0.979 |
| NPS | MRGPRX3 | ENSP00000381105 | ENSP00000379571 | Neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations; Endogenous ligands | Mas-related G-protein coupled receptor member X3; Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity); G protein-coupled receptors, Class A orphans | 0.540 |
| NPS | NMB | ENSP00000381105 | ENSP00000378089 | Neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations; Endogenous ligands | Neuromedin-B; Stimulates smooth muscle contraction in a manner similar to that of bombesin; Belongs to the bombesin/neuromedin-B/ranatensin family | 0.956 |
