node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCHCR1 | CDSN | ENSP00000379566 | ENSP00000365465 | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation | Corneodesmosin; Important for the epidermal barrier integrity | 0.756 |
CCHCR1 | KRT16 | ENSP00000379566 | ENSP00000301653 | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation | Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach- required for some inflammatory checkpoint for the skin barrier maintenance | 0.652 |
CCHCR1 | KRT17 | ENSP00000379566 | ENSP00000308452 | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation | Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a mark [...] | 0.777 |
CCHCR1 | MOG | ENSP00000379566 | ENSP00000366095 | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation | Myelin-oligodendrocyte glycoprotein; Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell- cell communication; Belongs to the immunoglobulin superfamily. BTN/MOG family | 0.652 |
CCHCR1 | PGA5 | ENSP00000379566 | ENSP00000309542 | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation | Pepsin A-5; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent | 0.670 |
CCHCR1 | PSORS1C1 | ENSP00000379566 | ENSP00000259881 | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation | Psoriasis susceptibility 1 candidate 1 | 0.669 |
CCHCR1 | PSORS1C2 | ENSP00000379566 | ENSP00000259845 | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation | Psoriasis susceptibility 1 candidate 2 | 0.668 |
CCHCR1 | RNF39 | ENSP00000379566 | ENSP00000244360 | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation | RING finger protein 39; May play a role in prolonged long term-potentiation (LTP) maintenance; Ring finger proteins | 0.698 |
CCHCR1 | TCF19 | ENSP00000379566 | ENSP00000365433 | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation | Transcription factor 19; Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression; PHD finger proteins | 0.802 |
CCHCR1 | ZNF57 | ENSP00000379566 | ENSP00000303696 | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation | Zinc finger protein 57; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.719 |
CDSN | CCHCR1 | ENSP00000365465 | ENSP00000379566 | Corneodesmosin; Important for the epidermal barrier integrity | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation | 0.756 |
CDSN | KRT16 | ENSP00000365465 | ENSP00000301653 | Corneodesmosin; Important for the epidermal barrier integrity | Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach- required for some inflammatory checkpoint for the skin barrier maintenance | 0.426 |
CDSN | KRT17 | ENSP00000365465 | ENSP00000308452 | Corneodesmosin; Important for the epidermal barrier integrity | Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a mark [...] | 0.406 |
CDSN | MOG | ENSP00000365465 | ENSP00000366095 | Corneodesmosin; Important for the epidermal barrier integrity | Myelin-oligodendrocyte glycoprotein; Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell- cell communication; Belongs to the immunoglobulin superfamily. BTN/MOG family | 0.595 |
CDSN | PSORS1C1 | ENSP00000365465 | ENSP00000259881 | Corneodesmosin; Important for the epidermal barrier integrity | Psoriasis susceptibility 1 candidate 1 | 0.839 |
CDSN | PSORS1C2 | ENSP00000365465 | ENSP00000259845 | Corneodesmosin; Important for the epidermal barrier integrity | Psoriasis susceptibility 1 candidate 2 | 0.598 |
CDSN | RNF39 | ENSP00000365465 | ENSP00000244360 | Corneodesmosin; Important for the epidermal barrier integrity | RING finger protein 39; May play a role in prolonged long term-potentiation (LTP) maintenance; Ring finger proteins | 0.689 |
CDSN | TCF19 | ENSP00000365465 | ENSP00000365433 | Corneodesmosin; Important for the epidermal barrier integrity | Transcription factor 19; Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression; PHD finger proteins | 0.707 |
CDSN | ZNF57 | ENSP00000365465 | ENSP00000303696 | Corneodesmosin; Important for the epidermal barrier integrity | Zinc finger protein 57; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.676 |
KRT16 | CCHCR1 | ENSP00000301653 | ENSP00000379566 | Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach- required for some inflammatory checkpoint for the skin barrier maintenance | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation | 0.652 |