ZNF418 protein (human) - STRING database

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ZNF418

Zinc finger protein 418; Transcriptional repressor; Zinc fingers C2H2-type (676 aa)

Predicted Functional Partners:

TRIM28

0.903

NWD1

0.587

ABTB1

0.492

PRDM7

0.456

GCN1L1

0.439

STK3

0.434

DNAH9

0.414

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABTB1	NWD1	ENSP00000232744	ENSP00000428579	Ankyrin repeat and BTB/POZ domain-containing protein 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes; Ankyrin repeat domain containing	NACHT domain- and WD repeat-containing protein 1; May play a role in the control of androgen receptor (AR) protein steady-state levels; WD repeat domain containing	0.451
ABTB1	ZNF418	ENSP00000232744	ENSP00000379451	Ankyrin repeat and BTB/POZ domain-containing protein 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes; Ankyrin repeat domain containing	Zinc finger protein 418; Transcriptional repressor; Zinc fingers C2H2-type	0.492
DNAH9	NWD1	ENSP00000262442	ENSP00000428579	Dynein heavy chain 9, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP; Dyneins, axonemal	NACHT domain- and WD repeat-containing protein 1; May play a role in the control of androgen receptor (AR) protein steady-state levels; WD repeat domain containing	0.411
DNAH9	ZNF418	ENSP00000262442	ENSP00000379451	Dynein heavy chain 9, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP; Dyneins, axonemal	Zinc finger protein 418; Transcriptional repressor; Zinc fingers C2H2-type	0.414
GCN1L1	NWD1	ENSP00000300648	ENSP00000428579	eIF-2-alpha kinase activator GCN1; Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA- binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by pr [...]	NACHT domain- and WD repeat-containing protein 1; May play a role in the control of androgen receptor (AR) protein steady-state levels; WD repeat domain containing	0.400
GCN1L1	ZNF418	ENSP00000300648	ENSP00000379451	eIF-2-alpha kinase activator GCN1; Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA- binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by pr [...]	Zinc finger protein 418; Transcriptional repressor; Zinc fingers C2H2-type	0.439
NWD1	ABTB1	ENSP00000428579	ENSP00000232744	NACHT domain- and WD repeat-containing protein 1; May play a role in the control of androgen receptor (AR) protein steady-state levels; WD repeat domain containing	Ankyrin repeat and BTB/POZ domain-containing protein 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes; Ankyrin repeat domain containing	0.451
NWD1	DNAH9	ENSP00000428579	ENSP00000262442	NACHT domain- and WD repeat-containing protein 1; May play a role in the control of androgen receptor (AR) protein steady-state levels; WD repeat domain containing	Dynein heavy chain 9, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP; Dyneins, axonemal	0.411
NWD1	GCN1L1	ENSP00000428579	ENSP00000300648	NACHT domain- and WD repeat-containing protein 1; May play a role in the control of androgen receptor (AR) protein steady-state levels; WD repeat domain containing	eIF-2-alpha kinase activator GCN1; Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA- binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by pr [...]	0.400
NWD1	ZNF418	ENSP00000428579	ENSP00000379451	NACHT domain- and WD repeat-containing protein 1; May play a role in the control of androgen receptor (AR) protein steady-state levels; WD repeat domain containing	Zinc finger protein 418; Transcriptional repressor; Zinc fingers C2H2-type	0.587
PRDM7	TRIM28	ENSP00000396732	ENSP00000253024	Probable histone-lysine N-methyltransferase PRDM7; Probable histone methyltransferase; PR/SET domain family	Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]	0.900
PRDM7	ZNF418	ENSP00000396732	ENSP00000379451	Probable histone-lysine N-methyltransferase PRDM7; Probable histone methyltransferase; PR/SET domain family	Zinc finger protein 418; Transcriptional repressor; Zinc fingers C2H2-type	0.456
STK3	ZNF418	ENSP00000429744	ENSP00000379451	Serine/threonine-protein kinase 3; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein [...]	Zinc finger protein 418; Transcriptional repressor; Zinc fingers C2H2-type	0.434
TRIM28	PRDM7	ENSP00000253024	ENSP00000396732	Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]	Probable histone-lysine N-methyltransferase PRDM7; Probable histone methyltransferase; PR/SET domain family	0.900
TRIM28	ZNF418	ENSP00000253024	ENSP00000379451	Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]	Zinc finger protein 418; Transcriptional repressor; Zinc fingers C2H2-type	0.903
ZNF418	ABTB1	ENSP00000379451	ENSP00000232744	Zinc finger protein 418; Transcriptional repressor; Zinc fingers C2H2-type	Ankyrin repeat and BTB/POZ domain-containing protein 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes; Ankyrin repeat domain containing	0.492
ZNF418	DNAH9	ENSP00000379451	ENSP00000262442	Zinc finger protein 418; Transcriptional repressor; Zinc fingers C2H2-type	Dynein heavy chain 9, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP; Dyneins, axonemal	0.414
ZNF418	GCN1L1	ENSP00000379451	ENSP00000300648	Zinc finger protein 418; Transcriptional repressor; Zinc fingers C2H2-type	eIF-2-alpha kinase activator GCN1; Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA- binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by pr [...]	0.439
ZNF418	NWD1	ENSP00000379451	ENSP00000428579	Zinc finger protein 418; Transcriptional repressor; Zinc fingers C2H2-type	NACHT domain- and WD repeat-containing protein 1; May play a role in the control of androgen receptor (AR) protein steady-state levels; WD repeat domain containing	0.587
ZNF418	PRDM7	ENSP00000379451	ENSP00000396732	Zinc finger protein 418; Transcriptional repressor; Zinc fingers C2H2-type	Probable histone-lysine N-methyltransferase PRDM7; Probable histone methyltransferase; PR/SET domain family	0.456

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