| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMBN | AMELX | ENSP00000313809 | ENSP00000370088 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | 0.995 |
| AMBN | AMTN | ENSP00000313809 | ENSP00000341013 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Amelotin; Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis | 0.987 |
| AMBN | DMP1 | ENSP00000313809 | ENSP00000340935 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Dentin matrix acidic phosphoprotein 1; May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite; SIBLING family | 0.951 |
| AMBN | ENAM | ENSP00000313809 | ENSP00000379383 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation | 0.992 |
| AMBN | FAM20A | ENSP00000313809 | ENSP00000468308 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the ’matrix’ that guides the deposition of the enamel minerals | 0.972 |
| AMBN | FAM20C | ENSP00000313809 | ENSP00000322323 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome. Mainly phosphorylates proteins within the Ser- x-Glu/pSer motif, but also displays a broader substrate specificity. Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1. [...] | 0.971 |
| AMBN | FBN1 | ENSP00000313809 | ENSP00000325527 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Fibrillin-1; Fibrillin-1- Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1- containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus w [...] | 0.908 |
| AMBN | MEPE | ENSP00000313809 | ENSP00000416984 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Matrix extracellular phosphoglycoprotein; Promotes renal phosphate excretion and modulates mineralization; SIBLING family | 0.951 |
| AMBN | SPARCL1 | ENSP00000313809 | ENSP00000414856 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | SPARC-like protein 1; SPARC family | 0.972 |
| AMBN | SPP1 | ENSP00000313809 | ENSP00000378517 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Endogenous ligands | 0.943 |
| AMELX | AMBN | ENSP00000370088 | ENSP00000313809 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family | 0.995 |
| AMELX | AMTN | ENSP00000370088 | ENSP00000341013 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Amelotin; Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis | 0.982 |
| AMELX | DMP1 | ENSP00000370088 | ENSP00000340935 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Dentin matrix acidic phosphoprotein 1; May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite; SIBLING family | 0.938 |
| AMELX | ENAM | ENSP00000370088 | ENSP00000379383 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation | 0.995 |
| AMELX | FAM20A | ENSP00000370088 | ENSP00000468308 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the ’matrix’ that guides the deposition of the enamel minerals | 0.963 |
| AMELX | FAM20C | ENSP00000370088 | ENSP00000322323 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome. Mainly phosphorylates proteins within the Ser- x-Glu/pSer motif, but also displays a broader substrate specificity. Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1. [...] | 0.974 |
| AMELX | FBN1 | ENSP00000370088 | ENSP00000325527 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Fibrillin-1; Fibrillin-1- Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1- containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus w [...] | 0.902 |
| AMELX | MEPE | ENSP00000370088 | ENSP00000416984 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Matrix extracellular phosphoglycoprotein; Promotes renal phosphate excretion and modulates mineralization; SIBLING family | 0.941 |
| AMELX | SPARCL1 | ENSP00000370088 | ENSP00000414856 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | SPARC-like protein 1; SPARC family | 0.940 |
| AMELX | SPP1 | ENSP00000370088 | ENSP00000378517 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Endogenous ligands | 0.945 |
