node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGR3 | CNPY3 | ENSP00000308606 | ENSP00000361926 | Anterior gradient protein 3; Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells; Belongs to the AGR family | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity); Belongs to the canopy family | 0.601 |
AGR3 | ERP27 | ENSP00000308606 | ENSP00000266397 | Anterior gradient protein 3; Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells; Belongs to the AGR family | Endoplasmic reticulum protein 27; Belongs to the protein disulfide isomerase family | 0.628 |
AGR3 | FAM172A | ENSP00000308606 | ENSP00000379294 | Anterior gradient protein 3; Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells; Belongs to the AGR family | Protein FAM172A; Family with sequence similarity 172 member A; Belongs to the UPF0528 family | 0.604 |
AGR3 | FKBP7 | ENSP00000308606 | ENSP00000413152 | Anterior gradient protein 3; Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells; Belongs to the AGR family | Peptidylprolyl isomerase; EF-hand domain containing | 0.597 |
AGR3 | FOXRED2 | ENSP00000308606 | ENSP00000380401 | Anterior gradient protein 3; Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells; Belongs to the AGR family | FAD-dependent oxidoreductase domain-containing protein 2; Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation | 0.585 |
AGR3 | PATE1 | ENSP00000308606 | ENSP00000307164 | Anterior gradient protein 3; Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells; Belongs to the AGR family | Prostate and testis expressed 1; Belongs to the PATE family | 0.552 |
AGR3 | PCYOX1 | ENSP00000308606 | ENSP00000387654 | Anterior gradient protein 3; Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells; Belongs to the AGR family | Prenylcysteine oxidase 1; Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine | 0.630 |
AGR3 | POGLUT1 | ENSP00000308606 | ENSP00000295588 | Anterior gradient protein 3; Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells; Belongs to the AGR family | Protein O-glucosyltransferase 1; Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C. Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2. Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development. Notch glucosylation does not affect Notch ligand binding. Required during early development to promote gastrulation- acts by mediating O- g [...] | 0.609 |
CNPY3 | AGR3 | ENSP00000361926 | ENSP00000308606 | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity); Belongs to the canopy family | Anterior gradient protein 3; Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells; Belongs to the AGR family | 0.601 |
CNPY3 | ERP27 | ENSP00000361926 | ENSP00000266397 | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity); Belongs to the canopy family | Endoplasmic reticulum protein 27; Belongs to the protein disulfide isomerase family | 0.553 |
CNPY3 | FAM172A | ENSP00000361926 | ENSP00000379294 | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity); Belongs to the canopy family | Protein FAM172A; Family with sequence similarity 172 member A; Belongs to the UPF0528 family | 0.622 |
CNPY3 | FKBP7 | ENSP00000361926 | ENSP00000413152 | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity); Belongs to the canopy family | Peptidylprolyl isomerase; EF-hand domain containing | 0.587 |
CNPY3 | FOXRED2 | ENSP00000361926 | ENSP00000380401 | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity); Belongs to the canopy family | FAD-dependent oxidoreductase domain-containing protein 2; Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation | 0.573 |
CNPY3 | PATE1 | ENSP00000361926 | ENSP00000307164 | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity); Belongs to the canopy family | Prostate and testis expressed 1; Belongs to the PATE family | 0.545 |
CNPY3 | PCYOX1 | ENSP00000361926 | ENSP00000387654 | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity); Belongs to the canopy family | Prenylcysteine oxidase 1; Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine | 0.616 |
CNPY3 | POGLUT1 | ENSP00000361926 | ENSP00000295588 | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity); Belongs to the canopy family | Protein O-glucosyltransferase 1; Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C. Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2. Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development. Notch glucosylation does not affect Notch ligand binding. Required during early development to promote gastrulation- acts by mediating O- g [...] | 0.603 |
ERP27 | AGR3 | ENSP00000266397 | ENSP00000308606 | Endoplasmic reticulum protein 27; Belongs to the protein disulfide isomerase family | Anterior gradient protein 3; Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells; Belongs to the AGR family | 0.628 |
ERP27 | CNPY3 | ENSP00000266397 | ENSP00000361926 | Endoplasmic reticulum protein 27; Belongs to the protein disulfide isomerase family | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity); Belongs to the canopy family | 0.553 |
ERP27 | FAM172A | ENSP00000266397 | ENSP00000379294 | Endoplasmic reticulum protein 27; Belongs to the protein disulfide isomerase family | Protein FAM172A; Family with sequence similarity 172 member A; Belongs to the UPF0528 family | 0.596 |
ERP27 | FKBP7 | ENSP00000266397 | ENSP00000413152 | Endoplasmic reticulum protein 27; Belongs to the protein disulfide isomerase family | Peptidylprolyl isomerase; EF-hand domain containing | 0.687 |