| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCDC15 | LRRC2 | ENSP00000341684 | ENSP00000379241 | Coiled-coil domain containing 15 | Leucine-rich repeat-containing protein 2; Leucine rich repeat containing 2 | 0.766 |
| CCDC15 | LSM3 | ENSP00000341684 | ENSP00000302160 | Coiled-coil domain containing 15 | U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3’-terminal U-tract of U6 snRNA; Belongs to the snRNP Sm proteins family | 0.554 |
| CCDC15 | OXSM | ENSP00000341684 | ENSP00000280701 | Coiled-coil domain containing 15 | 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function; Belongs to the beta-ketoacyl-ACP synthases family | 0.732 |
| CCDC15 | TRDN | ENSP00000341684 | ENSP00000439281 | Coiled-coil domain containing 15 | Triadin; Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact (By similarity). Required for normal skeletal muscle strength. Plays a role in excitation- contraction coupling in the heart and in regulating the rate of heart beats | 0.513 |
| DOCK3 | LRRC2 | ENSP00000266037 | ENSP00000379241 | Dedicator of cytokinesis protein 3; Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion re [...] | Leucine-rich repeat-containing protein 2; Leucine rich repeat containing 2 | 0.683 |
| LPHN1 | LRRC2 | ENSP00000340688 | ENSP00000379241 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Leucine-rich repeat-containing protein 2; Leucine rich repeat containing 2 | 0.685 |
| LPHN1 | LRRN1 | ENSP00000340688 | ENSP00000314901 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Leucine rich repeat neuronal 1; I-set domain containing | 0.685 |
| LPHN1 | LRRN2 | ENSP00000340688 | ENSP00000356143 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | Leucine rich repeat neuronal 2; I-set domain containing | 0.685 |
| LPHN2 | LRRC2 | ENSP00000322270 | ENSP00000379241 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Leucine-rich repeat-containing protein 2; Leucine rich repeat containing 2 | 0.685 |
| LPHN2 | LRRN1 | ENSP00000322270 | ENSP00000314901 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Leucine rich repeat neuronal 1; I-set domain containing | 0.685 |
| LPHN2 | LRRN2 | ENSP00000322270 | ENSP00000356143 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | Leucine rich repeat neuronal 2; I-set domain containing | 0.685 |
| LPHN3 | LRRC2 | ENSP00000422533 | ENSP00000379241 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | Leucine-rich repeat-containing protein 2; Leucine rich repeat containing 2 | 0.685 |
| LPHN3 | LRRN1 | ENSP00000422533 | ENSP00000314901 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | Leucine rich repeat neuronal 1; I-set domain containing | 0.685 |
| LPHN3 | LRRN2 | ENSP00000422533 | ENSP00000356143 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | Leucine rich repeat neuronal 2; I-set domain containing | 0.685 |
| LRRC2 | CCDC15 | ENSP00000379241 | ENSP00000341684 | Leucine-rich repeat-containing protein 2; Leucine rich repeat containing 2 | Coiled-coil domain containing 15 | 0.766 |
| LRRC2 | DOCK3 | ENSP00000379241 | ENSP00000266037 | Leucine-rich repeat-containing protein 2; Leucine rich repeat containing 2 | Dedicator of cytokinesis protein 3; Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion re [...] | 0.683 |
| LRRC2 | LPHN1 | ENSP00000379241 | ENSP00000340688 | Leucine-rich repeat-containing protein 2; Leucine rich repeat containing 2 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) | 0.685 |
| LRRC2 | LPHN2 | ENSP00000379241 | ENSP00000322270 | Leucine-rich repeat-containing protein 2; Leucine rich repeat containing 2 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily | 0.685 |
| LRRC2 | LPHN3 | ENSP00000379241 | ENSP00000422533 | Leucine-rich repeat-containing protein 2; Leucine rich repeat containing 2 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily | 0.685 |
| LRRC2 | LRRN1 | ENSP00000379241 | ENSP00000314901 | Leucine-rich repeat-containing protein 2; Leucine rich repeat containing 2 | Leucine rich repeat neuronal 1; I-set domain containing | 0.700 |
