node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATL1 | CDKL1 | ENSP00000351155 | ENSP00000379176 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | 0.552 |
CDKL1 | ATL1 | ENSP00000379176 | ENSP00000351155 | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily | 0.552 |
CDKL1 | CDKL4 | ENSP00000379176 | ENSP00000368080 | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | Cyclin-dependent kinase-like 4; Cyclin dependent kinase like 4 | 0.828 |
CDKL1 | CLMN | ENSP00000379176 | ENSP00000298912 | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | Calmin | 0.467 |
CDKL1 | DRC1 | ENSP00000379176 | ENSP00000288710 | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | Dynein regulatory complex protein 1; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending | 0.544 |
CDKL1 | EGF | ENSP00000379176 | ENSP00000265171 | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro | 0.468 |
CDKL1 | PCDH7 | ENSP00000379176 | ENSP00000441802 | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | Protocadherin-7; Protein phosphatase 1 regulatory subunits; Non-clustered protocadherins | 0.604 |
CDKL1 | PCDHB1 | ENSP00000379176 | ENSP00000307234 | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | Protocadherin beta-1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | 0.743 |
CDKL1 | TCTN2 | ENSP00000379176 | ENSP00000304941 | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | Tectonic-2; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction (By similarity) | 0.490 |
CDKL1 | TMEM138 | ENSP00000379176 | ENSP00000278826 | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | Transmembrane protein 138; Required for ciliogenesis | 0.584 |
CDKL1 | TMEM218 | ENSP00000379176 | ENSP00000436596 | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | Transmembrane protein 218; May be involved in ciliary biogenesis or function | 0.771 |
CDKL4 | CDKL1 | ENSP00000368080 | ENSP00000379176 | Cyclin-dependent kinase-like 4; Cyclin dependent kinase like 4 | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | 0.828 |
CDKL4 | DRC1 | ENSP00000368080 | ENSP00000288710 | Cyclin-dependent kinase-like 4; Cyclin dependent kinase like 4 | Dynein regulatory complex protein 1; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending | 0.484 |
CDKL4 | TMEM138 | ENSP00000368080 | ENSP00000278826 | Cyclin-dependent kinase-like 4; Cyclin dependent kinase like 4 | Transmembrane protein 138; Required for ciliogenesis | 0.624 |
CLMN | CDKL1 | ENSP00000298912 | ENSP00000379176 | Calmin | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | 0.467 |
DRC1 | CDKL1 | ENSP00000288710 | ENSP00000379176 | Dynein regulatory complex protein 1; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | 0.544 |
DRC1 | CDKL4 | ENSP00000288710 | ENSP00000368080 | Dynein regulatory complex protein 1; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending | Cyclin-dependent kinase-like 4; Cyclin dependent kinase like 4 | 0.484 |
EGF | CDKL1 | ENSP00000265171 | ENSP00000379176 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | 0.468 |
PCDH7 | CDKL1 | ENSP00000441802 | ENSP00000379176 | Protocadherin-7; Protein phosphatase 1 regulatory subunits; Non-clustered protocadherins | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | 0.604 |
PCDHB1 | CDKL1 | ENSP00000307234 | ENSP00000379176 | Protocadherin beta-1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 | 0.743 |