• Version:
  • 11.0 [archived version]
STRINGSTRING
TCTN2 TCTN2 PCDH7 PCDH7 TMEM218 TMEM218 CLMN CLMN TMEM138 TMEM138 CDKL1 CDKL1 CDKL4 CDKL4 ATL1 ATL1 DRC1 DRC1 PCDHB1 PCDHB1 EGF EGF
"CDKL1" - Cyclin-dependent kinase-like 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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[Homology]
Score
CDKL1Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 (358 aa)    
Predicted Functional Partners:
CDKL4
Cyclin-dependent kinase-like 4; Cyclin dependent kinase like 4 (315 aa)
   
 
 
0.828
TMEM218
Transmembrane protein 218; May be involved in ciliary biogenesis or function (115 aa)
           
  0.771
PCDHB1
Protocadherin beta-1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins (818 aa)
     
   
  0.743
PCDH7
Protocadherin-7; Protein phosphatase 1 regulatory subunits; Non-clustered protocadherins (1072 aa)
     
   
  0.604
TMEM138
Transmembrane protein 138; Required for ciliogenesis (162 aa)
     
   
  0.584
ATL1
Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily (558 aa)
     
   
  0.552
DRC1
Dynein regulatory complex protein 1; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending (740 aa)
     
   
  0.544
TCTN2
Tectonic-2; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction (By similarity) (697 aa)
           
  0.490
EGF
Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro (1207 aa)
           
  0.468
CLMN
Calmin (1002 aa)
           
  0.467
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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