• Version:
  • 11.0 [archived version]
STRINGSTRING
HEATR1 HEATR1 RASAL2 RASAL2 KIAA1324L KIAA1324L CRISPLD1 CRISPLD1 METRNL METRNL CHD1L CHD1L ZNF287 ZNF287 ABHD17B ABHD17B CDRT4 CDRT4 TRIM28 TRIM28 SAMD11 SAMD11
"ZNF287" - Zinc finger protein 287 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ZNF287Zinc finger protein 287; May be involved in transcriptional regulation; SCAN domain containing (761 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
     
  0.905
CRISPLD1
Cysteine rich secretory protein LCCL domain containing 1; Belongs to the CRISP family (500 aa)
           
  0.598
KIAA1324L
UPF0577 protein KIAA1324-like; KIAA1324 like; Belongs to the UPF0577 family (1029 aa)
       
 
  0.596
ABHD17B
Protein ABHD17B; Abhydrolase domain containing 17B; Belongs to the AB hydrolase superfamily. ABHD17 family (293 aa)
     
   
  0.540
SAMD11
Sterile alpha motif domain-containing protein 11; May play a role in photoreceptor development; Sterile alpha motif domain containing (681 aa)
       
 
  0.534
CDRT4
CMT1A duplicated region transcript 4 (152 aa)
           
  0.533
METRNL
Meteorin-like protein; Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates a [...] (311 aa)
           
  0.496
HEATR1
HEAT repeat-containing protein 1; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre- ribosomal RNA transcription by RNA polymerase I; Belongs to the HEATR1/UTP10 family (2144 aa)
           
  0.491
CHD1L
Chromodomain-helicase-DNA-binding protein 1-like; DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding; Belongs to the SNF2/RAD54 helicase family (897 aa)
       
 
  0.460
RASAL2
Ras GTPase-activating protein nGAP; Inhibitory regulator of the Ras-cyclic AMP pathway; C2 and RasGAP domain containing (1280 aa)
           
  0.457
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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