| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMT | ATIC | ENSP00000273588 | ENSP00000236959 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family | 0.962 |
| AMT | GART | ENSP00000273588 | ENSP00000371253 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family | 0.952 |
| AMT | MTHFD1L | ENSP00000273588 | ENSP00000478253 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | Monofunctional C1-tetrahydrofolate synthase, mitochondrial; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family | 0.965 |
| AMT | MTHFD2 | ENSP00000273588 | ENSP00000377617 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency; Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family | 0.979 |
| AMT | MTHFD2L | ENSP00000273588 | ENSP00000379108 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2; Methylenetetrahydrofolate dehydrogenase 2 like | 0.976 |
| AMT | MTHFR | ENSP00000273588 | ENSP00000365777 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | Methylenetetrahydrofolate reductase; Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine | 0.959 |
| AMT | MTHFS | ENSP00000273588 | ENSP00000258874 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | 5-formyltetrahydrofolate cyclo-ligase; Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate | 0.521 |
| AMT | SHMT1 | ENSP00000273588 | ENSP00000318868 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine | 0.988 |
| AMT | SHMT2 | ENSP00000273588 | ENSP00000333667 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | Serine hydroxymethyltransferase, mitochondrial; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism. Thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA. Plays a role in the deubiquitination of target proteins as component of the BRISC complex. Required for IFNAR1 deubiquitination by the BRISC complex; Belongs to the SHMT family | 0.989 |
| AMT | TYMS | ENSP00000273588 | ENSP00000315644 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway | 0.951 |
| ATIC | AMT | ENSP00000236959 | ENSP00000273588 | Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | 0.962 |
| ATIC | GART | ENSP00000236959 | ENSP00000371253 | Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family | Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family | 0.999 |
| ATIC | MTHFD1L | ENSP00000236959 | ENSP00000478253 | Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family | Monofunctional C1-tetrahydrofolate synthase, mitochondrial; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family | 0.959 |
| ATIC | MTHFD2 | ENSP00000236959 | ENSP00000377617 | Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency; Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family | 0.980 |
| ATIC | MTHFD2L | ENSP00000236959 | ENSP00000379108 | Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family | Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2; Methylenetetrahydrofolate dehydrogenase 2 like | 0.976 |
| ATIC | MTHFR | ENSP00000236959 | ENSP00000365777 | Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family | Methylenetetrahydrofolate reductase; Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine | 0.665 |
| ATIC | MTHFS | ENSP00000236959 | ENSP00000258874 | Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family | 5-formyltetrahydrofolate cyclo-ligase; Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate | 0.587 |
| ATIC | SHMT1 | ENSP00000236959 | ENSP00000318868 | Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine | 0.995 |
| ATIC | SHMT2 | ENSP00000236959 | ENSP00000333667 | Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family | Serine hydroxymethyltransferase, mitochondrial; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism. Thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA. Plays a role in the deubiquitination of target proteins as component of the BRISC complex. Required for IFNAR1 deubiquitination by the BRISC complex; Belongs to the SHMT family | 0.993 |
| ATIC | TYMS | ENSP00000236959 | ENSP00000315644 | Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family | Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway | 0.861 |
