| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDA | DPYD | ENSP00000364212 | ENSP00000359211 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil; Belongs to the dihydropyrimidine dehydrogenase family | 0.728 |
| CDA | NT5C | ENSP00000364212 | ENSP00000245552 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | 5’(3’)-deoxyribonucleotidase, cytosolic type; Dephosphorylates the 5’ and 2’(3’)-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP; Belongs to the 5’(3’)-deoxyribonucleotidase family | 0.931 |
| CDA | NT5M | ENSP00000364212 | ENSP00000373674 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | 5’(3’)-deoxyribonucleotidase, mitochondrial; Dephosphorylates specifically the 5’ and 2’(3’)- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP; 5’-nucleotidases | 0.906 |
| CDA | TK1 | ENSP00000364212 | ENSP00000301634 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | Thymidine kinase, cytosolic; Thymidine kinase 1; Belongs to the thymidine kinase family | 0.980 |
| CDA | TK2 | ENSP00000364212 | ENSP00000299697 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | Thymidine kinase 2, mitochondrial; Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK. Widely used as target of antiviral and chemotherapeutic agents; Belongs to the DCK/DGK family | 0.910 |
| CDA | TYMP | ENSP00000364212 | ENSP00000379038 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | Thymidine phosphorylase; May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro; Minor histocompatibility antigens | 0.997 |
| CDA | UMPS | ENSP00000364212 | ENSP00000232607 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | Uridine 5’-monophosphate synthase; Uridine monophosphate synthetase; In the C-terminal section; belongs to the OMP decarboxylase family | 0.777 |
| CDA | UPP1 | ENSP00000364212 | ENSP00000330032 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | Uridine phosphorylase 1; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis; Belongs to the PNP/UDP phosphorylase family | 0.977 |
| CDA | UPP2 | ENSP00000364212 | ENSP00000474090 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | Uridine phosphorylase 2; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(’)-deoxyuridine as substrates | 0.961 |
| CDA | UPRT | ENSP00000364212 | ENSP00000362481 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | Uracil phosphoribosyltransferase homolog; Belongs to the UPRTase family | 0.774 |
| DPYD | CDA | ENSP00000359211 | ENSP00000364212 | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil; Belongs to the dihydropyrimidine dehydrogenase family | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | 0.728 |
| DPYD | TK1 | ENSP00000359211 | ENSP00000301634 | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil; Belongs to the dihydropyrimidine dehydrogenase family | Thymidine kinase, cytosolic; Thymidine kinase 1; Belongs to the thymidine kinase family | 0.635 |
| DPYD | TYMP | ENSP00000359211 | ENSP00000379038 | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil; Belongs to the dihydropyrimidine dehydrogenase family | Thymidine phosphorylase; May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro; Minor histocompatibility antigens | 0.990 |
| DPYD | UMPS | ENSP00000359211 | ENSP00000232607 | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil; Belongs to the dihydropyrimidine dehydrogenase family | Uridine 5’-monophosphate synthase; Uridine monophosphate synthetase; In the C-terminal section; belongs to the OMP decarboxylase family | 0.994 |
| DPYD | UPP1 | ENSP00000359211 | ENSP00000330032 | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil; Belongs to the dihydropyrimidine dehydrogenase family | Uridine phosphorylase 1; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis; Belongs to the PNP/UDP phosphorylase family | 0.976 |
| DPYD | UPP2 | ENSP00000359211 | ENSP00000474090 | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil; Belongs to the dihydropyrimidine dehydrogenase family | Uridine phosphorylase 2; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(’)-deoxyuridine as substrates | 0.948 |
| DPYD | UPRT | ENSP00000359211 | ENSP00000362481 | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil; Belongs to the dihydropyrimidine dehydrogenase family | Uracil phosphoribosyltransferase homolog; Belongs to the UPRTase family | 0.944 |
| NT5C | CDA | ENSP00000245552 | ENSP00000364212 | 5’(3’)-deoxyribonucleotidase, cytosolic type; Dephosphorylates the 5’ and 2’(3’)-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP; Belongs to the 5’(3’)-deoxyribonucleotidase family | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis | 0.931 |
| NT5C | NT5M | ENSP00000245552 | ENSP00000373674 | 5’(3’)-deoxyribonucleotidase, cytosolic type; Dephosphorylates the 5’ and 2’(3’)-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP; Belongs to the 5’(3’)-deoxyribonucleotidase family | 5’(3’)-deoxyribonucleotidase, mitochondrial; Dephosphorylates specifically the 5’ and 2’(3’)- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP; 5’-nucleotidases | 0.812 |
| NT5C | TK1 | ENSP00000245552 | ENSP00000301634 | 5’(3’)-deoxyribonucleotidase, cytosolic type; Dephosphorylates the 5’ and 2’(3’)-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP; Belongs to the 5’(3’)-deoxyribonucleotidase family | Thymidine kinase, cytosolic; Thymidine kinase 1; Belongs to the thymidine kinase family | 0.926 |
