| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C16orf62 | KCNV2 | ENSP00000251143 | ENSP00000371514 | UPF0505 protein C16orf62; Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability; Belongs to the UPF0505 family | Potassium voltage-gated channel subfamily V member 2; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values; Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.2/KCNV2 sub-subfamily | 0.535 |
| C16orf62 | SLC5A10 | ENSP00000251143 | ENSP00000379008 | UPF0505 protein C16orf62; Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability; Belongs to the UPF0505 family | Sodium/glucose cotransporter 5; High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | 0.583 |
| FAM83G | SLC5A10 | ENSP00000373647 | ENSP00000379008 | Protein FAM83G; May regulate the bone morphogenetic proteins (BMP) pathway | Sodium/glucose cotransporter 5; High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | 0.770 |
| KCNV2 | C16orf62 | ENSP00000371514 | ENSP00000251143 | Potassium voltage-gated channel subfamily V member 2; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values; Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.2/KCNV2 sub-subfamily | UPF0505 protein C16orf62; Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability; Belongs to the UPF0505 family | 0.535 |
| KCNV2 | SLC5A10 | ENSP00000371514 | ENSP00000379008 | Potassium voltage-gated channel subfamily V member 2; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values; Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.2/KCNV2 sub-subfamily | Sodium/glucose cotransporter 5; High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | 0.522 |
| LMF1 | MARCH6 | ENSP00000262301 | ENSP00000274140 | Lipase maturation factor 1; Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway. Each LMF1 molecule chaperones 50 or more molecules of LPL | E3 ubiquitin-protein ligase MARCH6; E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1; Membrane associated ring-CH-type fingers | 0.564 |
| LMF1 | SLC5A10 | ENSP00000262301 | ENSP00000379008 | Lipase maturation factor 1; Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway. Each LMF1 molecule chaperones 50 or more molecules of LPL | Sodium/glucose cotransporter 5; High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | 0.567 |
| LMF1 | SLC9B2 | ENSP00000262301 | ENSP00000378265 | Lipase maturation factor 1; Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway. Each LMF1 molecule chaperones 50 or more molecules of LPL | Sodium/hydrogen exchanger 9B2; Na(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane. Contributes to the regulation of intracellular pH, sodium homeostasis, and cell volume. Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta- cells (By similarity). Involved in sperm motility and fertility (By similarity). It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (By similarity); Solute carriers | 0.522 |
| MARCH6 | LMF1 | ENSP00000274140 | ENSP00000262301 | E3 ubiquitin-protein ligase MARCH6; E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1; Membrane associated ring-CH-type fingers | Lipase maturation factor 1; Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway. Each LMF1 molecule chaperones 50 or more molecules of LPL | 0.564 |
| MARCH6 | SLC5A10 | ENSP00000274140 | ENSP00000379008 | E3 ubiquitin-protein ligase MARCH6; E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1; Membrane associated ring-CH-type fingers | Sodium/glucose cotransporter 5; High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | 0.532 |
| MARCH6 | SLC9B2 | ENSP00000274140 | ENSP00000378265 | E3 ubiquitin-protein ligase MARCH6; E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1; Membrane associated ring-CH-type fingers | Sodium/hydrogen exchanger 9B2; Na(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane. Contributes to the regulation of intracellular pH, sodium homeostasis, and cell volume. Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta- cells (By similarity). Involved in sperm motility and fertility (By similarity). It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (By similarity); Solute carriers | 0.511 |
| SLC2A10 | SLC5A10 | ENSP00000352216 | ENSP00000379008 | Solute carrier family 2, facilitated glucose transporter member 10; Facilitative glucose transporter; Solute carriers | Sodium/glucose cotransporter 5; High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | 0.595 |
| SLC2A2 | SLC5A10 | ENSP00000323568 | ENSP00000379008 | Solute carrier family 2, facilitated glucose transporter member 2; Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily | Sodium/glucose cotransporter 5; High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | 0.616 |
| SLC35F5 | SLC5A10 | ENSP00000245680 | ENSP00000379008 | Solute carrier family 35 member F5; Putative solute transporter; Belongs to the SLC35F solute transporter family | Sodium/glucose cotransporter 5; High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | 0.532 |
| SLC5A10 | C16orf62 | ENSP00000379008 | ENSP00000251143 | Sodium/glucose cotransporter 5; High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | UPF0505 protein C16orf62; Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability; Belongs to the UPF0505 family | 0.583 |
| SLC5A10 | FAM83G | ENSP00000379008 | ENSP00000373647 | Sodium/glucose cotransporter 5; High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | Protein FAM83G; May regulate the bone morphogenetic proteins (BMP) pathway | 0.770 |
| SLC5A10 | KCNV2 | ENSP00000379008 | ENSP00000371514 | Sodium/glucose cotransporter 5; High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | Potassium voltage-gated channel subfamily V member 2; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values; Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.2/KCNV2 sub-subfamily | 0.522 |
| SLC5A10 | LMF1 | ENSP00000379008 | ENSP00000262301 | Sodium/glucose cotransporter 5; High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | Lipase maturation factor 1; Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway. Each LMF1 molecule chaperones 50 or more molecules of LPL | 0.567 |
| SLC5A10 | MARCH6 | ENSP00000379008 | ENSP00000274140 | Sodium/glucose cotransporter 5; High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | E3 ubiquitin-protein ligase MARCH6; E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1; Membrane associated ring-CH-type fingers | 0.532 |
| SLC5A10 | SLC2A10 | ENSP00000379008 | ENSP00000352216 | Sodium/glucose cotransporter 5; High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose; Belongs to the sodium-solute symporter (SSF) (TC 2.A.21) family | Solute carrier family 2, facilitated glucose transporter member 10; Facilitative glucose transporter; Solute carriers | 0.595 |
