node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EN1 | FGF8 | ENSP00000295206 | ENSP00000321797 | Homeobox protein engrailed-1; NKL subclass homeoboxes and pseudogenes | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells; Belongs to the heparin-binding growth factors family | 0.826 |
EN1 | LBH | ENSP00000295206 | ENSP00000378733 | Homeobox protein engrailed-1; NKL subclass homeoboxes and pseudogenes | Protein LBH; Transcriptional activator which may act in mitogen- activated protein kinase signaling pathway; Belongs to the LBH family | 0.647 |
FGF8 | EN1 | ENSP00000321797 | ENSP00000295206 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells; Belongs to the heparin-binding growth factors family | Homeobox protein engrailed-1; NKL subclass homeoboxes and pseudogenes | 0.826 |
FGF8 | LBH | ENSP00000321797 | ENSP00000378733 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells; Belongs to the heparin-binding growth factors family | Protein LBH; Transcriptional activator which may act in mitogen- activated protein kinase signaling pathway; Belongs to the LBH family | 0.507 |
HTR2B | LBH | ENSP00000258400 | ENSP00000378733 | 5-hydroxytryptamine receptor 2B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol- calcium second messenger system that modulates the activity [...] | Protein LBH; Transcriptional activator which may act in mitogen- activated protein kinase signaling pathway; Belongs to the LBH family | 0.405 |
IL1B | LBH | ENSP00000263341 | ENSP00000378733 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells | Protein LBH; Transcriptional activator which may act in mitogen- activated protein kinase signaling pathway; Belongs to the LBH family | 0.429 |
LBH | EN1 | ENSP00000378733 | ENSP00000295206 | Protein LBH; Transcriptional activator which may act in mitogen- activated protein kinase signaling pathway; Belongs to the LBH family | Homeobox protein engrailed-1; NKL subclass homeoboxes and pseudogenes | 0.647 |
LBH | FGF8 | ENSP00000378733 | ENSP00000321797 | Protein LBH; Transcriptional activator which may act in mitogen- activated protein kinase signaling pathway; Belongs to the LBH family | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells; Belongs to the heparin-binding growth factors family | 0.507 |
LBH | HTR2B | ENSP00000378733 | ENSP00000258400 | Protein LBH; Transcriptional activator which may act in mitogen- activated protein kinase signaling pathway; Belongs to the LBH family | 5-hydroxytryptamine receptor 2B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol- calcium second messenger system that modulates the activity [...] | 0.405 |
LBH | IL1B | ENSP00000378733 | ENSP00000263341 | Protein LBH; Transcriptional activator which may act in mitogen- activated protein kinase signaling pathway; Belongs to the LBH family | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells | 0.429 |
LBH | LGALS4 | ENSP00000378733 | ENSP00000302100 | Protein LBH; Transcriptional activator which may act in mitogen- activated protein kinase signaling pathway; Belongs to the LBH family | Galectin-4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions; Galectins | 0.527 |
LBH | LMCD1 | ENSP00000378733 | ENSP00000157600 | Protein LBH; Transcriptional activator which may act in mitogen- activated protein kinase signaling pathway; Belongs to the LBH family | LIM and cysteine-rich domains protein 1; Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue- specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway; LIM domain containing | 0.596 |
LBH | RIN2 | ENSP00000378733 | ENSP00000255006 | Protein LBH; Transcriptional activator which may act in mitogen- activated protein kinase signaling pathway; Belongs to the LBH family | Ras and Rab interactor 2; Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP; Belongs to the RIN (Ras interaction/interference) family | 0.512 |
LBH | TMEM88B | ENSP00000378733 | ENSP00000455099 | Protein LBH; Transcriptional activator which may act in mitogen- activated protein kinase signaling pathway; Belongs to the LBH family | Transmembrane protein 88B | 0.405 |
LBH | VGLL3 | ENSP00000378733 | ENSP00000381436 | Protein LBH; Transcriptional activator which may act in mitogen- activated protein kinase signaling pathway; Belongs to the LBH family | Transcription cofactor vestigial-like protein 3; May act as a specific coactivator for the mammalian TEFs; Vestigial like family | 0.458 |
LBH | YPEL5 | ENSP00000378733 | ENSP00000368835 | Protein LBH; Transcriptional activator which may act in mitogen- activated protein kinase signaling pathway; Belongs to the LBH family | Protein yippee-like 5; Yippee like family; Belongs to the yippee family | 0.400 |
LGALS4 | LBH | ENSP00000302100 | ENSP00000378733 | Galectin-4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions; Galectins | Protein LBH; Transcriptional activator which may act in mitogen- activated protein kinase signaling pathway; Belongs to the LBH family | 0.527 |
LMCD1 | LBH | ENSP00000157600 | ENSP00000378733 | LIM and cysteine-rich domains protein 1; Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue- specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway; LIM domain containing | Protein LBH; Transcriptional activator which may act in mitogen- activated protein kinase signaling pathway; Belongs to the LBH family | 0.596 |
RIN2 | LBH | ENSP00000255006 | ENSP00000378733 | Ras and Rab interactor 2; Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP; Belongs to the RIN (Ras interaction/interference) family | Protein LBH; Transcriptional activator which may act in mitogen- activated protein kinase signaling pathway; Belongs to the LBH family | 0.512 |
TMEM88B | LBH | ENSP00000455099 | ENSP00000378733 | Transmembrane protein 88B | Protein LBH; Transcriptional activator which may act in mitogen- activated protein kinase signaling pathway; Belongs to the LBH family | 0.405 |