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STRINGSTRING
NUP210 NUP210 AAAS AAAS TMEM242 TMEM242 NUP85 NUP85 URB1 URB1 IZUMO4 IZUMO4 CD9 CD9 IZUMO2 IZUMO2 TSSK6 TSSK6 IZUMO3 IZUMO3 IZUMO1 IZUMO1
"IZUMO4" - Izumo sperm-egg fusion protein 4 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
IZUMO4Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family (232 aa)    
Predicted Functional Partners:
CD9
CD9 antigen; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion; Belongs to the tetraspanin (TM4SF) family (228 aa)
          
  0.942
IZUMO2
Izumo sperm-egg fusion protein 2; IZUMO family member 2 (221 aa)
            
  0.895
IZUMO3
Izumo sperm-egg fusion protein 3; IZUMO family member 3 (233 aa)
            
  0.861
TMEM242
Transmembrane protein 242; Belongs to the TMEM242 family (141 aa)
            
  0.788
NUP210
Nuclear pore membrane glycoprotein 210; Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity; Nucleoporins (1887 aa)
        
      0.742
NUP85
Nuclear pore complex protein Nup85; Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade; Nucl [...] (656 aa)
        
      0.742
AAAS
Aladin; Plays a role in the normal development of the peripheral and central nervous system; Nucleoporins (546 aa)
        
      0.742
IZUMO1
Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1-IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane ’fusogen’ (350 aa)
            
  0.707
URB1
Nucleolar pre-ribosomal-associated protein 1; Armadillo-like helical domain containing (2271 aa)
            
  0.693
TSSK6
Testis-specific serine/threonine-protein kinase 6; Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity) (273 aa)
      
   
  0.635
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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