node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C5orf24 | CAB39 | ENSP00000378427 | ENSP00000258418 | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family | Calcium-binding protein 39; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 | 0.540 |
C5orf24 | LSMEM2 | ENSP00000378427 | ENSP00000315081 | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family | Leucine rich single-pass membrane protein 2 | 0.668 |
C5orf24 | PKNOX1 | ENSP00000378427 | ENSP00000291547 | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family | Homeobox protein PKNOX1; TALE class homeoboxes and pseudogenes | 0.719 |
C5orf24 | PRRC2C | ENSP00000378427 | ENSP00000343629 | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family | Protein PRRC2C; Proline rich coiled-coil 2C | 0.578 |
C5orf24 | PRRG4 | ENSP00000378427 | ENSP00000257836 | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family | Transmembrane gamma-carboxyglutamic acid protein 4; Proline rich and Gla domain containing | 0.509 |
C5orf24 | STK11 | ENSP00000378427 | ENSP00000324856 | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family | Serine/threonine-protein kinase STK11; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity- phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non- AMPK family proteins such as STRADA, PTEN and possibly p53/T [...] | 0.600 |
C5orf24 | STRADA | ENSP00000378427 | ENSP00000336655 | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family | STE20-related kinase adapter protein alpha; Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation | 0.747 |
C5orf24 | TBC1D29 | ENSP00000378427 | ENSP00000462799 | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family | TBC1 domain family member 29 | 0.641 |
C5orf24 | ZNF330 | ENSP00000378427 | ENSP00000262990 | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family | Zinc finger protein 330; Zinc fingers C2H2-type | 0.620 |
C5orf24 | ZNF551 | ENSP00000378427 | ENSP00000282296 | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family | Zinc finger protein 551; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.549 |
CAB39 | C5orf24 | ENSP00000258418 | ENSP00000378427 | Calcium-binding protein 39; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family | 0.540 |
CAB39 | STK11 | ENSP00000258418 | ENSP00000324856 | Calcium-binding protein 39; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 | Serine/threonine-protein kinase STK11; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity- phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non- AMPK family proteins such as STRADA, PTEN and possibly p53/T [...] | 0.999 |
CAB39 | STRADA | ENSP00000258418 | ENSP00000336655 | Calcium-binding protein 39; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 | STE20-related kinase adapter protein alpha; Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation | 0.999 |
LSMEM2 | C5orf24 | ENSP00000315081 | ENSP00000378427 | Leucine rich single-pass membrane protein 2 | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family | 0.668 |
LSMEM2 | TBC1D29 | ENSP00000315081 | ENSP00000462799 | Leucine rich single-pass membrane protein 2 | TBC1 domain family member 29 | 0.707 |
LSMEM2 | ZNF551 | ENSP00000315081 | ENSP00000282296 | Leucine rich single-pass membrane protein 2 | Zinc finger protein 551; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.668 |
PKNOX1 | C5orf24 | ENSP00000291547 | ENSP00000378427 | Homeobox protein PKNOX1; TALE class homeoboxes and pseudogenes | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family | 0.719 |
PRRC2C | C5orf24 | ENSP00000343629 | ENSP00000378427 | Protein PRRC2C; Proline rich coiled-coil 2C | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family | 0.578 |
PRRC2C | PRRG4 | ENSP00000343629 | ENSP00000257836 | Protein PRRC2C; Proline rich coiled-coil 2C | Transmembrane gamma-carboxyglutamic acid protein 4; Proline rich and Gla domain containing | 0.457 |
PRRG4 | C5orf24 | ENSP00000257836 | ENSP00000378427 | Transmembrane gamma-carboxyglutamic acid protein 4; Proline rich and Gla domain containing | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family | 0.509 |