• Version:
  • 11.0 [archived version]
STRINGSTRING
PKNOX1 PKNOX1 ZNF330 ZNF330 PRRG4 PRRG4 TBC1D29 TBC1D29 C5orf24 C5orf24 PRRC2C PRRC2C LSMEM2 LSMEM2 ZNF551 ZNF551 STK11 STK11 STRADA STRADA CAB39 CAB39
"C5orf24" - UPF0461 protein C5orf24 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
C5orf24UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family (188 aa)    
Predicted Functional Partners:
STRADA
STE20-related kinase adapter protein alpha; Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (431 aa)
       
      0.747
PKNOX1
Homeobox protein PKNOX1; TALE class homeoboxes and pseudogenes (436 aa)
       
      0.719
LSMEM2
Leucine rich single-pass membrane protein 2 (164 aa)
           
  0.668
TBC1D29
TBC1 domain family member 29 (150 aa)
           
  0.641
ZNF330
Zinc finger protein 330; Zinc fingers C2H2-type (320 aa)
           
  0.620
STK11
Serine/threonine-protein kinase STK11; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity- phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non- AMPK family proteins such as STRADA, PTEN and possibly p53/T [...] (433 aa)
       
      0.600
PRRC2C
Protein PRRC2C; Proline rich coiled-coil 2C (2817 aa)
     
   
  0.578
ZNF551
Zinc finger protein 551; May be involved in transcriptional regulation; Zinc fingers C2H2-type (670 aa)
           
  0.549
CAB39
Calcium-binding protein 39; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (341 aa)
       
      0.540
PRRG4
Transmembrane gamma-carboxyglutamic acid protein 4; Proline rich and Gla domain containing (226 aa)
           
  0.509
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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