| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKRD13B | CCDC91 | ENSP00000378328 | ENSP00000438040 | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | Coiled-coil domain-containing protein 91; Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes | 0.479 |
| ANKRD13B | FAM208A | ENSP00000378328 | ENSP00000417509 | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | Protein TASOR; Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3; Belongs to the FAM208 family | 0.556 |
| ANKRD13B | LRRC37B | ENSP00000378328 | ENSP00000340519 | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | Leucine-rich repeat-containing protein 37B; Leucine rich repeat containing 37B | 0.558 |
| ANKRD13B | TTC7A | ENSP00000378328 | ENSP00000378320 | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | Tetratricopeptide repeat protein 7A; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, plays a central role in bridging PI4KA to EFR3B and FAM126A, via direct interactions (By similarity) | 0.422 |
| ANKRD13B | ZBTB24 | ENSP00000378328 | ENSP00000230122 | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | Zinc finger and BTB domain-containing protein 24; May be involved in BMP2-induced transcription; BTB domain containing | 0.441 |
| ANKRD13B | ZDHHC24 | ENSP00000378328 | ENSP00000309429 | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | Probable palmitoyltransferase ZDHHC24; Zinc finger DHHC-type containing 24; Belongs to the DHHC palmitoyltransferase family | 0.446 |
| ANKRD13B | ZNFX1 | ENSP00000378328 | ENSP00000379412 | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | Zinc finger NFX1-type containing 1; UPF1 like RNA helicases | 0.454 |
| CCDC91 | ANKRD13B | ENSP00000438040 | ENSP00000378328 | Coiled-coil domain-containing protein 91; Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | 0.479 |
| FAM208A | ANKRD13B | ENSP00000417509 | ENSP00000378328 | Protein TASOR; Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3; Belongs to the FAM208 family | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | 0.556 |
| FAM208A | LRRC37B | ENSP00000417509 | ENSP00000340519 | Protein TASOR; Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3; Belongs to the FAM208 family | Leucine-rich repeat-containing protein 37B; Leucine rich repeat containing 37B | 0.495 |
| LRRC37B | ANKRD13B | ENSP00000340519 | ENSP00000378328 | Leucine-rich repeat-containing protein 37B; Leucine rich repeat containing 37B | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | 0.558 |
| LRRC37B | FAM208A | ENSP00000340519 | ENSP00000417509 | Leucine-rich repeat-containing protein 37B; Leucine rich repeat containing 37B | Protein TASOR; Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3; Belongs to the FAM208 family | 0.495 |
| TTC7A | ANKRD13B | ENSP00000378320 | ENSP00000378328 | Tetratricopeptide repeat protein 7A; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (Probable). In the complex, plays a central role in bridging PI4KA to EFR3B and FAM126A, via direct interactions (By similarity) | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | 0.422 |
| ZBTB24 | ANKRD13B | ENSP00000230122 | ENSP00000378328 | Zinc finger and BTB domain-containing protein 24; May be involved in BMP2-induced transcription; BTB domain containing | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | 0.441 |
| ZDHHC24 | ANKRD13B | ENSP00000309429 | ENSP00000378328 | Probable palmitoyltransferase ZDHHC24; Zinc finger DHHC-type containing 24; Belongs to the DHHC palmitoyltransferase family | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | 0.446 |
| ZNFX1 | ANKRD13B | ENSP00000379412 | ENSP00000378328 | Zinc finger NFX1-type containing 1; UPF1 like RNA helicases | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds ’Lys-63’-linked ubiquitin. Does not bind ’Lys-48’-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane; Ankyrin repeat domain containing | 0.454 |
