• Version:
  • 11.0 [archived version]
STRINGSTRING
KRT17 KRT17 KRT13 KRT13 KRT19 KRT19 KRT81 KRT81 KRT14 KRT14 KRT7 KRT7 KRT20 KRT20 KRT80 KRT80 KRT15 KRT15 KRT16 KRT16 KRT38 KRT38
"KRT80" - Keratin, type II cytoskeletal 80 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
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Cooccurence
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[Homology]
Score
KRT80Keratin, type II cytoskeletal 80; Keratins, type II (452 aa)    
Predicted Functional Partners:
KRT16
Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach- required for some inflammatory checkpoint for the skin barrier maintenance (473 aa)
     
0.939
KRT17
Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a mark [...] (432 aa)
     
0.938
KRT15
Keratin, type I cytoskeletal 15; Keratins, type I (456 aa)
     
0.938
KRT14
Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro (472 aa)
     
0.935
KRT20
Keratin, type I cytoskeletal 20; Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity); Keratins, type I (424 aa)
     
0.935
KRT19
Keratin, type I cytoskeletal 19; Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle; Keratins, type I (400 aa)
     
0.934
KRT7
Keratin, type II cytoskeletal 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7); Keratins, type II (469 aa)
     
 
0.933
KRT38
Keratin, type I cuticular Ha8; Keratins, type I; Belongs to the intermediate filament family (456 aa)
     
0.931
KRT81
Keratin, type II cuticular Hb1; Keratins, type II (505 aa)
     
 
0.929
KRT13
Keratin, type I cytoskeletal 13; Keratins, type I (458 aa)
     
0.928
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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