| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C14orf169 | KDM8 | ENSP00000477507 | ENSP00000398410 | Ribosomal oxygenase 1; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates ’Lys-4’ (H3K4me) and ’Lys-36’ (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ (H3K4me3) and monomethylated H3 ’Lys-4’ (H3K4me1) residues, while it has weaker activity for dimethylated H3 ’Lys-36’ (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on ’His-216’. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX [...] | JmjC domain-containing protein 5; Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated ’Lys-36’ (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. In a complex with coregulator RCCD1, is also able to demethylate trimethylated ’Lys-36’ (H3K36me3) of histone H3. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions [...] | 0.798 |
| C14orf169 | RCCD1 | ENSP00000477507 | ENSP00000377801 | Ribosomal oxygenase 1; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates ’Lys-4’ (H3K4me) and ’Lys-36’ (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ (H3K4me3) and monomethylated H3 ’Lys-4’ (H3K4me1) residues, while it has weaker activity for dimethylated H3 ’Lys-36’ (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on ’His-216’. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX [...] | RCC1 domain-containing protein 1; Acts as a coregulator of KDM8 to promote histone demethylase activity on di- and trimethylated ’Lys-36’ (H3K36me2/me3) of histone H3. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha- tubulin deacetylation and cytoskeletal microtubule stability and thereby promoting cell migration and TGF-beta-induced epithelial [...] | 0.544 |
| C14orf169 | TYW5 | ENSP00000477507 | ENSP00000346627 | Ribosomal oxygenase 1; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates ’Lys-4’ (H3K4me) and ’Lys-36’ (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ (H3K4me3) and monomethylated H3 ’Lys-4’ (H3K4me1) residues, while it has weaker activity for dimethylated H3 ’Lys-36’ (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on ’His-216’. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX [...] | tRNA wybutosine-synthesizing protein 5; tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3’-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes; Belongs to the TYW5 family | 0.751 |
| CCDC130 | KDM8 | ENSP00000465776 | ENSP00000398410 | Coiled-coil domain containing 130; Belongs to the CWC16 family | JmjC domain-containing protein 5; Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated ’Lys-36’ (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. In a complex with coregulator RCCD1, is also able to demethylate trimethylated ’Lys-36’ (H3K36me3) of histone H3. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions [...] | 0.823 |
| CCDC130 | RCCD1 | ENSP00000465776 | ENSP00000377801 | Coiled-coil domain containing 130; Belongs to the CWC16 family | RCC1 domain-containing protein 1; Acts as a coregulator of KDM8 to promote histone demethylase activity on di- and trimethylated ’Lys-36’ (H3K36me2/me3) of histone H3. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha- tubulin deacetylation and cytoskeletal microtubule stability and thereby promoting cell migration and TGF-beta-induced epithelial [...] | 0.674 |
| DACT3 | RCCD1 | ENSP00000375783 | ENSP00000377801 | Dapper homolog 3; May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins | RCC1 domain-containing protein 1; Acts as a coregulator of KDM8 to promote histone demethylase activity on di- and trimethylated ’Lys-36’ (H3K36me2/me3) of histone H3. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha- tubulin deacetylation and cytoskeletal microtubule stability and thereby promoting cell migration and TGF-beta-induced epithelial [...] | 0.525 |
| DACT3 | WDFY4 | ENSP00000375783 | ENSP00000320563 | Dapper homolog 3; May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins | WD repeat- and FYVE domain-containing protein 4; Armadillo-like helical domain containing | 0.401 |
| HDDC3 | RCCD1 | ENSP00000377814 | ENSP00000377801 | Guanosine-3’,5’-bis(diphosphate) 3’-pyrophosphohydrolase MESH1; ppGpp hydrolyzing enzyme involved in starvation response | RCC1 domain-containing protein 1; Acts as a coregulator of KDM8 to promote histone demethylase activity on di- and trimethylated ’Lys-36’ (H3K36me2/me3) of histone H3. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha- tubulin deacetylation and cytoskeletal microtubule stability and thereby promoting cell migration and TGF-beta-induced epithelial [...] | 0.531 |
| KDM8 | C14orf169 | ENSP00000398410 | ENSP00000477507 | JmjC domain-containing protein 5; Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated ’Lys-36’ (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. In a complex with coregulator RCCD1, is also able to demethylate trimethylated ’Lys-36’ (H3K36me3) of histone H3. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions [...] | Ribosomal oxygenase 1; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates ’Lys-4’ (H3K4me) and ’Lys-36’ (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ (H3K4me3) and monomethylated H3 ’Lys-4’ (H3K4me1) residues, while it has weaker activity for dimethylated H3 ’Lys-36’ (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on ’His-216’. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX [...] | 0.798 |
| KDM8 | CCDC130 | ENSP00000398410 | ENSP00000465776 | JmjC domain-containing protein 5; Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated ’Lys-36’ (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. In a complex with coregulator RCCD1, is also able to demethylate trimethylated ’Lys-36’ (H3K36me3) of histone H3. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions [...] | Coiled-coil domain containing 130; Belongs to the CWC16 family | 0.823 |
| KDM8 | RCCD1 | ENSP00000398410 | ENSP00000377801 | JmjC domain-containing protein 5; Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated ’Lys-36’ (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. In a complex with coregulator RCCD1, is also able to demethylate trimethylated ’Lys-36’ (H3K36me3) of histone H3. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions [...] | RCC1 domain-containing protein 1; Acts as a coregulator of KDM8 to promote histone demethylase activity on di- and trimethylated ’Lys-36’ (H3K36me2/me3) of histone H3. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha- tubulin deacetylation and cytoskeletal microtubule stability and thereby promoting cell migration and TGF-beta-induced epithelial [...] | 0.959 |
| LRTM1 | RCCD1 | ENSP00000273286 | ENSP00000377801 | Leucine rich repeats and transmembrane domains 1 | RCC1 domain-containing protein 1; Acts as a coregulator of KDM8 to promote histone demethylase activity on di- and trimethylated ’Lys-36’ (H3K36me2/me3) of histone H3. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha- tubulin deacetylation and cytoskeletal microtubule stability and thereby promoting cell migration and TGF-beta-induced epithelial [...] | 0.504 |
| OPRD1 | RCCD1 | ENSP00000234961 | ENSP00000377801 | Delta-type opioid receptor; G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. [...] | RCC1 domain-containing protein 1; Acts as a coregulator of KDM8 to promote histone demethylase activity on di- and trimethylated ’Lys-36’ (H3K36me2/me3) of histone H3. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha- tubulin deacetylation and cytoskeletal microtubule stability and thereby promoting cell migration and TGF-beta-induced epithelial [...] | 0.586 |
| RAN | RCCD1 | ENSP00000446215 | ENSP00000377801 | GTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment a [...] | RCC1 domain-containing protein 1; Acts as a coregulator of KDM8 to promote histone demethylase activity on di- and trimethylated ’Lys-36’ (H3K36me2/me3) of histone H3. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha- tubulin deacetylation and cytoskeletal microtubule stability and thereby promoting cell migration and TGF-beta-induced epithelial [...] | 0.501 |
| RCCD1 | C14orf169 | ENSP00000377801 | ENSP00000477507 | RCC1 domain-containing protein 1; Acts as a coregulator of KDM8 to promote histone demethylase activity on di- and trimethylated ’Lys-36’ (H3K36me2/me3) of histone H3. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha- tubulin deacetylation and cytoskeletal microtubule stability and thereby promoting cell migration and TGF-beta-induced epithelial [...] | Ribosomal oxygenase 1; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates ’Lys-4’ (H3K4me) and ’Lys-36’ (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ (H3K4me3) and monomethylated H3 ’Lys-4’ (H3K4me1) residues, while it has weaker activity for dimethylated H3 ’Lys-36’ (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on ’His-216’. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX [...] | 0.544 |
| RCCD1 | CCDC130 | ENSP00000377801 | ENSP00000465776 | RCC1 domain-containing protein 1; Acts as a coregulator of KDM8 to promote histone demethylase activity on di- and trimethylated ’Lys-36’ (H3K36me2/me3) of histone H3. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha- tubulin deacetylation and cytoskeletal microtubule stability and thereby promoting cell migration and TGF-beta-induced epithelial [...] | Coiled-coil domain containing 130; Belongs to the CWC16 family | 0.674 |
| RCCD1 | DACT3 | ENSP00000377801 | ENSP00000375783 | RCC1 domain-containing protein 1; Acts as a coregulator of KDM8 to promote histone demethylase activity on di- and trimethylated ’Lys-36’ (H3K36me2/me3) of histone H3. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha- tubulin deacetylation and cytoskeletal microtubule stability and thereby promoting cell migration and TGF-beta-induced epithelial [...] | Dapper homolog 3; May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins | 0.525 |
| RCCD1 | HDDC3 | ENSP00000377801 | ENSP00000377814 | RCC1 domain-containing protein 1; Acts as a coregulator of KDM8 to promote histone demethylase activity on di- and trimethylated ’Lys-36’ (H3K36me2/me3) of histone H3. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha- tubulin deacetylation and cytoskeletal microtubule stability and thereby promoting cell migration and TGF-beta-induced epithelial [...] | Guanosine-3’,5’-bis(diphosphate) 3’-pyrophosphohydrolase MESH1; ppGpp hydrolyzing enzyme involved in starvation response | 0.531 |
| RCCD1 | KDM8 | ENSP00000377801 | ENSP00000398410 | RCC1 domain-containing protein 1; Acts as a coregulator of KDM8 to promote histone demethylase activity on di- and trimethylated ’Lys-36’ (H3K36me2/me3) of histone H3. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha- tubulin deacetylation and cytoskeletal microtubule stability and thereby promoting cell migration and TGF-beta-induced epithelial [...] | JmjC domain-containing protein 5; Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated ’Lys-36’ (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. In a complex with coregulator RCCD1, is also able to demethylate trimethylated ’Lys-36’ (H3K36me3) of histone H3. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions [...] | 0.959 |
| RCCD1 | LRTM1 | ENSP00000377801 | ENSP00000273286 | RCC1 domain-containing protein 1; Acts as a coregulator of KDM8 to promote histone demethylase activity on di- and trimethylated ’Lys-36’ (H3K36me2/me3) of histone H3. Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha- tubulin deacetylation and cytoskeletal microtubule stability and thereby promoting cell migration and TGF-beta-induced epithelial [...] | Leucine rich repeats and transmembrane domains 1 | 0.504 |
