| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALDH1L2 | AMT | ENSP00000258494 | ENSP00000273588 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; Aldehyde dehydrogenase 1 family member L2; In the N-terminal section; belongs to the GART family | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | 0.933 |
| ALDH1L2 | GART | ENSP00000258494 | ENSP00000371253 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; Aldehyde dehydrogenase 1 family member L2; In the N-terminal section; belongs to the GART family | Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family | 0.916 |
| ALDH1L2 | MTHFD2 | ENSP00000258494 | ENSP00000377617 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; Aldehyde dehydrogenase 1 family member L2; In the N-terminal section; belongs to the GART family | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency; Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family | 0.965 |
| ALDH1L2 | MTHFD2L | ENSP00000258494 | ENSP00000379108 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; Aldehyde dehydrogenase 1 family member L2; In the N-terminal section; belongs to the GART family | Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2; Methylenetetrahydrofolate dehydrogenase 2 like | 0.944 |
| ALDH1L2 | SHMT1 | ENSP00000258494 | ENSP00000318868 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; Aldehyde dehydrogenase 1 family member L2; In the N-terminal section; belongs to the GART family | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine | 0.964 |
| ALDH1L2 | SHMT2 | ENSP00000258494 | ENSP00000333667 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; Aldehyde dehydrogenase 1 family member L2; In the N-terminal section; belongs to the GART family | Serine hydroxymethyltransferase, mitochondrial; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism. Thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA. Plays a role in the deubiquitination of target proteins as component of the BRISC complex. Required for IFNAR1 deubiquitination by the BRISC complex; Belongs to the SHMT family | 0.969 |
| AMT | ALDH1L2 | ENSP00000273588 | ENSP00000258494 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; Aldehyde dehydrogenase 1 family member L2; In the N-terminal section; belongs to the GART family | 0.933 |
| AMT | ATIC | ENSP00000273588 | ENSP00000236959 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family | 0.962 |
| AMT | GART | ENSP00000273588 | ENSP00000371253 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family | 0.952 |
| AMT | MTFMT | ENSP00000273588 | ENSP00000220058 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | Methionyl-tRNA formyltransferase, mitochondrial; Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and an elongator species via an unknown mechanism (By similarity) | 0.928 |
| AMT | MTHFD2 | ENSP00000273588 | ENSP00000377617 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency; Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family | 0.979 |
| AMT | MTHFD2L | ENSP00000273588 | ENSP00000379108 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2; Methylenetetrahydrofolate dehydrogenase 2 like | 0.976 |
| AMT | MTHFR | ENSP00000273588 | ENSP00000365777 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | Methylenetetrahydrofolate reductase; Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine | 0.959 |
| AMT | SHMT1 | ENSP00000273588 | ENSP00000318868 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine | 0.988 |
| AMT | SHMT2 | ENSP00000273588 | ENSP00000333667 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | Serine hydroxymethyltransferase, mitochondrial; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism. Thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA. Plays a role in the deubiquitination of target proteins as component of the BRISC complex. Required for IFNAR1 deubiquitination by the BRISC complex; Belongs to the SHMT family | 0.989 |
| AMT | TYMS | ENSP00000273588 | ENSP00000315644 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway | 0.951 |
| ATIC | AMT | ENSP00000236959 | ENSP00000273588 | Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine | 0.962 |
| ATIC | GART | ENSP00000236959 | ENSP00000371253 | Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family | Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central section; belongs to the AIR synthase family | 0.999 |
| ATIC | MTFMT | ENSP00000236959 | ENSP00000220058 | Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family | Methionyl-tRNA formyltransferase, mitochondrial; Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and an elongator species via an unknown mechanism (By similarity) | 0.543 |
| ATIC | MTHFD2 | ENSP00000236959 | ENSP00000377617 | Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency; Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family | 0.980 |
