• Version:
  • 11.0 [archived version]
STRINGSTRING
MCM7 MCM7 CDC6 CDC6 MCM5 MCM5 PARM1 PARM1 TOMM34 TOMM34 GRTP1 GRTP1 CCNJL CCNJL TMTC2 TMTC2 OIT3 OIT3 ADAD2 ADAD2 HLF HLF
"CCNJL" - Cyclin-J-like protein in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CCNJLCyclin-J-like protein; Cyclin J like; Cyclins (435 aa)    
Predicted Functional Partners:
TOMM34
Mitochondrial import receptor subunit TOM34; Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state; Tetratricopeptide repeat domain containing (309 aa)
     
 
  0.649
MCM5
DNA replication licensing factor MCM5; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (734 aa)
     
 
  0.629
CDC6
Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated (560 aa)
     
 
  0.585
TMTC2
Transmembrane and tetratricopeptide repeat containing 2 (836 aa)
     
 
  0.557
ADAD2
Adenosine deaminase domain containing 2; Adenosine deaminases acting on RNA (665 aa)
           
  0.554
GRTP1
Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s) (344 aa)
     
 
  0.549
HLF
Hepatic leukemia factor; HLF, PAR bZIP transcription factor; Belongs to the bZIP family. PAR subfamily (295 aa)
           
  0.537
MCM7
DNA replication licensing factor MCM7; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
     
 
  0.527
PARM1
Prostate androgen-regulated mucin-like protein 1; May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis (310 aa)
           
  0.526
OIT3
Oncoprotein-induced transcript 3 protein; May be involved in hepatocellular function and development (545 aa)
           
  0.516
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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