node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADIPOR1 | C1QTNF2 | ENSP00000341785 | ENSP00000377545 | Adiponectin receptor protein 1; Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity); Belongs to the ADIPOR family | Complement C1q tumor necrosis factor-related protein 2; C1q and TNF related 2 | 0.538 |
ADIPOR1 | CD93 | ENSP00000341785 | ENSP00000246006 | Adiponectin receptor protein 1; Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity); Belongs to the ADIPOR family | Complement component C1q receptor; Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion; C-type lectin domain containing | 0.505 |
ADIPOR1 | CFAP97 | ENSP00000341785 | ENSP00000409964 | Adiponectin receptor protein 1; Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity); Belongs to the ADIPOR family | Cilia and flagella associated protein 97 | 0.543 |
ADIPOR1 | GPT | ENSP00000341785 | ENSP00000378408 | Adiponectin receptor protein 1; Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity); Belongs to the ADIPOR family | Alanine aminotransferase 1; Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily | 0.446 |
ADIPOR1 | SRRM2 | ENSP00000341785 | ENSP00000301740 | Adiponectin receptor protein 1; Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity); Belongs to the ADIPOR family | Serine/arginine repetitive matrix protein 2; Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). Binds to RNA; Belongs to the CWC21 family | 0.400 |
C1QTNF2 | ADIPOR1 | ENSP00000377545 | ENSP00000341785 | Complement C1q tumor necrosis factor-related protein 2; C1q and TNF related 2 | Adiponectin receptor protein 1; Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity); Belongs to the ADIPOR family | 0.538 |
C1QTNF2 | CD93 | ENSP00000377545 | ENSP00000246006 | Complement C1q tumor necrosis factor-related protein 2; C1q and TNF related 2 | Complement component C1q receptor; Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion; C-type lectin domain containing | 0.548 |
C1QTNF2 | CFAP97 | ENSP00000377545 | ENSP00000409964 | Complement C1q tumor necrosis factor-related protein 2; C1q and TNF related 2 | Cilia and flagella associated protein 97 | 0.572 |
C1QTNF2 | FAM132A | ENSP00000377545 | ENSP00000329137 | Complement C1q tumor necrosis factor-related protein 2; C1q and TNF related 2 | Adipolin; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue | 0.449 |
C1QTNF2 | FAM132B | ENSP00000377545 | ENSP00000442304 | Complement C1q tumor necrosis factor-related protein 2; C1q and TNF related 2 | Erythroferrone; Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage- produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake; Belongs to the adipolin/erythroferrone family | 0.478 |
C1QTNF2 | GPT | ENSP00000377545 | ENSP00000378408 | Complement C1q tumor necrosis factor-related protein 2; C1q and TNF related 2 | Alanine aminotransferase 1; Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily | 0.485 |
C1QTNF2 | MTX2 | ENSP00000377545 | ENSP00000249442 | Complement C1q tumor necrosis factor-related protein 2; C1q and TNF related 2 | Metaxin-2; Involved in transport of proteins into the mitochondrion | 0.738 |
C1QTNF2 | NAT9 | ENSP00000377545 | ENSP00000350467 | Complement C1q tumor necrosis factor-related protein 2; C1q and TNF related 2 | GCN5 related N-acetyltransferases; Belongs to the acetyltransferase family. GNAT subfamily | 0.686 |
C1QTNF2 | SRRM2 | ENSP00000377545 | ENSP00000301740 | Complement C1q tumor necrosis factor-related protein 2; C1q and TNF related 2 | Serine/arginine repetitive matrix protein 2; Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). Binds to RNA; Belongs to the CWC21 family | 0.435 |
C1QTNF2 | SZT2 | ENSP00000377545 | ENSP00000457168 | Complement C1q tumor necrosis factor-related protein 2; C1q and TNF related 2 | KICSTOR complex protein SZT2; As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by gluco [...] | 0.666 |
CD93 | ADIPOR1 | ENSP00000246006 | ENSP00000341785 | Complement component C1q receptor; Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion; C-type lectin domain containing | Adiponectin receptor protein 1; Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity); Belongs to the ADIPOR family | 0.505 |
CD93 | C1QTNF2 | ENSP00000246006 | ENSP00000377545 | Complement component C1q receptor; Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion; C-type lectin domain containing | Complement C1q tumor necrosis factor-related protein 2; C1q and TNF related 2 | 0.548 |
CD93 | CFAP97 | ENSP00000246006 | ENSP00000409964 | Complement component C1q receptor; Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion; C-type lectin domain containing | Cilia and flagella associated protein 97 | 0.529 |
CD93 | GPT | ENSP00000246006 | ENSP00000378408 | Complement component C1q receptor; Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion; C-type lectin domain containing | Alanine aminotransferase 1; Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily | 0.434 |
CD93 | SRRM2 | ENSP00000246006 | ENSP00000301740 | Complement component C1q receptor; Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion; C-type lectin domain containing | Serine/arginine repetitive matrix protein 2; Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). Binds to RNA; Belongs to the CWC21 family | 0.400 |