MOSPD3 protein (human) - STRING database

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MOSPD3

Motile sperm domain containing 3 (235 aa)

Predicted Functional Partners:

TBC1D22A

0.606

TMEM120A

0.602

PI4KA

0.556

ART5

0.543

C14orf1

0.486

OSBPL6

0.483

OSBP2

0.483

OSBPL3

0.483

OSBP

0.483

OSBPL7

0.483

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ART5	MOSPD3	ENSP00000380258	ENSP00000377522	ADP-ribosyltransferase 5	Motile sperm domain containing 3	0.543
C14orf1	MOSPD3	ENSP00000256319	ENSP00000377522	Probable ergosterol biosynthetic protein 28; Chromosome 14 open reading frame 1; Belongs to the ERG28 family	Motile sperm domain containing 3	0.486
MOSPD3	ART5	ENSP00000377522	ENSP00000380258	Motile sperm domain containing 3	ADP-ribosyltransferase 5	0.543
MOSPD3	C14orf1	ENSP00000377522	ENSP00000256319	Motile sperm domain containing 3	Probable ergosterol biosynthetic protein 28; Chromosome 14 open reading frame 1; Belongs to the ERG28 family	0.486
MOSPD3	OSBP	ENSP00000377522	ENSP00000263847	Motile sperm domain containing 3	Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum- specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol c [...]	0.483
MOSPD3	OSBP2	ENSP00000377522	ENSP00000332576	Motile sperm domain containing 3	Oxysterol-binding protein 2; Binds 7-ketocholesterol; Oxysterol binding proteins	0.483
MOSPD3	OSBPL3	ENSP00000377522	ENSP00000315410	Motile sperm domain containing 3	Oxysterol-binding protein-related protein 3; Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 [...]	0.483
MOSPD3	OSBPL6	ENSP00000377522	ENSP00000376293	Motile sperm domain containing 3	Oxysterol-binding protein-related protein 6; Weakly binds 25-hydroxycholesterol; Belongs to the OSBP family	0.483
MOSPD3	OSBPL7	ENSP00000377522	ENSP00000007414	Motile sperm domain containing 3	Oxysterol-binding protein-related protein 7; Pleckstrin homology domain containing; Belongs to the OSBP family	0.483
MOSPD3	PI4KA	ENSP00000377522	ENSP00000255882	Motile sperm domain containing 3	Phosphatidylinositol 4-kinase alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily	0.556
MOSPD3	TBC1D22A	ENSP00000377522	ENSP00000336724	Motile sperm domain containing 3	TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s)	0.606
MOSPD3	TMEM120A	ENSP00000377522	ENSP00000473983	Motile sperm domain containing 3	Transmembrane protein 120A; Necessary for efficient adipogenesis; Belongs to the TMEM120 family	0.602
OSBP	MOSPD3	ENSP00000263847	ENSP00000377522	Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum- specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol c [...]	Motile sperm domain containing 3	0.483
OSBP	PI4KA	ENSP00000263847	ENSP00000255882	Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum- specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol c [...]	Phosphatidylinositol 4-kinase alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily	0.716
OSBP2	MOSPD3	ENSP00000332576	ENSP00000377522	Oxysterol-binding protein 2; Binds 7-ketocholesterol; Oxysterol binding proteins	Motile sperm domain containing 3	0.483
OSBPL3	MOSPD3	ENSP00000315410	ENSP00000377522	Oxysterol-binding protein-related protein 3; Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 [...]	Motile sperm domain containing 3	0.483
OSBPL6	MOSPD3	ENSP00000376293	ENSP00000377522	Oxysterol-binding protein-related protein 6; Weakly binds 25-hydroxycholesterol; Belongs to the OSBP family	Motile sperm domain containing 3	0.483
OSBPL7	MOSPD3	ENSP00000007414	ENSP00000377522	Oxysterol-binding protein-related protein 7; Pleckstrin homology domain containing; Belongs to the OSBP family	Motile sperm domain containing 3	0.483
PI4KA	MOSPD3	ENSP00000255882	ENSP00000377522	Phosphatidylinositol 4-kinase alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily	Motile sperm domain containing 3	0.556
PI4KA	OSBP	ENSP00000255882	ENSP00000263847	Phosphatidylinositol 4-kinase alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily	Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum- specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol c [...]	0.716

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