node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ART5 | MOSPD3 | ENSP00000380258 | ENSP00000377522 | ADP-ribosyltransferase 5 | Motile sperm domain containing 3 | 0.543 |
C14orf1 | MOSPD3 | ENSP00000256319 | ENSP00000377522 | Probable ergosterol biosynthetic protein 28; Chromosome 14 open reading frame 1; Belongs to the ERG28 family | Motile sperm domain containing 3 | 0.486 |
MOSPD3 | ART5 | ENSP00000377522 | ENSP00000380258 | Motile sperm domain containing 3 | ADP-ribosyltransferase 5 | 0.543 |
MOSPD3 | C14orf1 | ENSP00000377522 | ENSP00000256319 | Motile sperm domain containing 3 | Probable ergosterol biosynthetic protein 28; Chromosome 14 open reading frame 1; Belongs to the ERG28 family | 0.486 |
MOSPD3 | OSBP | ENSP00000377522 | ENSP00000263847 | Motile sperm domain containing 3 | Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum- specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol c [...] | 0.483 |
MOSPD3 | OSBP2 | ENSP00000377522 | ENSP00000332576 | Motile sperm domain containing 3 | Oxysterol-binding protein 2; Binds 7-ketocholesterol; Oxysterol binding proteins | 0.483 |
MOSPD3 | OSBPL3 | ENSP00000377522 | ENSP00000315410 | Motile sperm domain containing 3 | Oxysterol-binding protein-related protein 3; Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 [...] | 0.483 |
MOSPD3 | OSBPL6 | ENSP00000377522 | ENSP00000376293 | Motile sperm domain containing 3 | Oxysterol-binding protein-related protein 6; Weakly binds 25-hydroxycholesterol; Belongs to the OSBP family | 0.483 |
MOSPD3 | OSBPL7 | ENSP00000377522 | ENSP00000007414 | Motile sperm domain containing 3 | Oxysterol-binding protein-related protein 7; Pleckstrin homology domain containing; Belongs to the OSBP family | 0.483 |
MOSPD3 | PI4KA | ENSP00000377522 | ENSP00000255882 | Motile sperm domain containing 3 | Phosphatidylinositol 4-kinase alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily | 0.556 |
MOSPD3 | TBC1D22A | ENSP00000377522 | ENSP00000336724 | Motile sperm domain containing 3 | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s) | 0.606 |
MOSPD3 | TMEM120A | ENSP00000377522 | ENSP00000473983 | Motile sperm domain containing 3 | Transmembrane protein 120A; Necessary for efficient adipogenesis; Belongs to the TMEM120 family | 0.602 |
OSBP | MOSPD3 | ENSP00000263847 | ENSP00000377522 | Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum- specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol c [...] | Motile sperm domain containing 3 | 0.483 |
OSBP | PI4KA | ENSP00000263847 | ENSP00000255882 | Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum- specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol c [...] | Phosphatidylinositol 4-kinase alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily | 0.716 |
OSBP2 | MOSPD3 | ENSP00000332576 | ENSP00000377522 | Oxysterol-binding protein 2; Binds 7-ketocholesterol; Oxysterol binding proteins | Motile sperm domain containing 3 | 0.483 |
OSBPL3 | MOSPD3 | ENSP00000315410 | ENSP00000377522 | Oxysterol-binding protein-related protein 3; Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 [...] | Motile sperm domain containing 3 | 0.483 |
OSBPL6 | MOSPD3 | ENSP00000376293 | ENSP00000377522 | Oxysterol-binding protein-related protein 6; Weakly binds 25-hydroxycholesterol; Belongs to the OSBP family | Motile sperm domain containing 3 | 0.483 |
OSBPL7 | MOSPD3 | ENSP00000007414 | ENSP00000377522 | Oxysterol-binding protein-related protein 7; Pleckstrin homology domain containing; Belongs to the OSBP family | Motile sperm domain containing 3 | 0.483 |
PI4KA | MOSPD3 | ENSP00000255882 | ENSP00000377522 | Phosphatidylinositol 4-kinase alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily | Motile sperm domain containing 3 | 0.556 |
PI4KA | OSBP | ENSP00000255882 | ENSP00000263847 | Phosphatidylinositol 4-kinase alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily | Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum- specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol c [...] | 0.716 |