ZNF414 protein (human) - STRING database

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ZNF414

Zinc finger protein 414; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family (390 aa)

Predicted Functional Partners:

CCDC97

0.599

KDM4A

0.580

KDM4B

0.570

RNF6

0.557

PRAM1

0.553

SEC22A

0.543

C19orf54

0.537

TMEM63B

0.527

MED16

0.523

DEPDC5

0.523

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C19orf54	CCDC97	ENSP00000367564	ENSP00000269967	UPF0692 protein C19orf54; Chromosome 19 open reading frame 54; Belongs to the UPF0692 family	Coiled-coil domain containing 97	0.541
C19orf54	ZNF414	ENSP00000367564	ENSP00000377504	UPF0692 protein C19orf54; Chromosome 19 open reading frame 54; Belongs to the UPF0692 family	Zinc finger protein 414; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	0.537
CCDC97	C19orf54	ENSP00000269967	ENSP00000367564	Coiled-coil domain containing 97	UPF0692 protein C19orf54; Chromosome 19 open reading frame 54; Belongs to the UPF0692 family	0.541
CCDC97	ZNF414	ENSP00000269967	ENSP00000377504	Coiled-coil domain containing 97	Zinc finger protein 414; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	0.599
DEPDC5	ZNF414	ENSP00000383105	ENSP00000377504	GATOR complex protein DEPDC5; As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway	Zinc finger protein 414; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	0.523
KDM4A	KDM4B	ENSP00000361473	ENSP00000159111	Lysine-specific demethylase 4A; Histone demethylase that specifically demethylates ’Lys- 9’ and ’Lys-36’ residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’ nor H4 ’Lys-20’. Demethylates trimethylated H3 ’Lys-9’ and H3 ’Lys-36’ residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively; Lysi [...]	Lysine-specific demethylase 4B; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’, H3 ’Lys-36’ nor H4 ’Lys-20’. Only able to demethylate trimethylated H3 ’Lys-9’, with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate; Lysine demethylases	0.968
KDM4A	ZNF414	ENSP00000361473	ENSP00000377504	Lysine-specific demethylase 4A; Histone demethylase that specifically demethylates ’Lys- 9’ and ’Lys-36’ residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’ nor H4 ’Lys-20’. Demethylates trimethylated H3 ’Lys-9’ and H3 ’Lys-36’ residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively; Lysi [...]	Zinc finger protein 414; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	0.580
KDM4B	KDM4A	ENSP00000159111	ENSP00000361473	Lysine-specific demethylase 4B; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’, H3 ’Lys-36’ nor H4 ’Lys-20’. Only able to demethylate trimethylated H3 ’Lys-9’, with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate; Lysine demethylases	Lysine-specific demethylase 4A; Histone demethylase that specifically demethylates ’Lys- 9’ and ’Lys-36’ residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’ nor H4 ’Lys-20’. Demethylates trimethylated H3 ’Lys-9’ and H3 ’Lys-36’ residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively; Lysi [...]	0.968
KDM4B	ZNF414	ENSP00000159111	ENSP00000377504	Lysine-specific demethylase 4B; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’, H3 ’Lys-36’ nor H4 ’Lys-20’. Only able to demethylate trimethylated H3 ’Lys-9’, with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate; Lysine demethylases	Zinc finger protein 414; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	0.570
MED16	ZNF414	ENSP00000325612	ENSP00000377504	Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors	Zinc finger protein 414; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	0.523
PRAM1	ZNF414	ENSP00000408342	ENSP00000377504	PML-RARA-regulated adapter molecule 1; May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P	Zinc finger protein 414; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	0.553
RNF6	SEC22A	ENSP00000371000	ENSP00000310521	E3 ubiquitin-protein ligase RNF6; E3 ubiquitin-protein ligase mediating ’Lys-48’-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates ’Lys-6’ and ’Lys-27’-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator; Ring finger proteins	Vesicle-trafficking protein SEC22a; May be involved in vesicle transport between the ER and the Golgi complex; SNAREs	0.433
RNF6	ZNF414	ENSP00000371000	ENSP00000377504	E3 ubiquitin-protein ligase RNF6; E3 ubiquitin-protein ligase mediating ’Lys-48’-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates ’Lys-6’ and ’Lys-27’-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator; Ring finger proteins	Zinc finger protein 414; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	0.557
SEC22A	RNF6	ENSP00000310521	ENSP00000371000	Vesicle-trafficking protein SEC22a; May be involved in vesicle transport between the ER and the Golgi complex; SNAREs	E3 ubiquitin-protein ligase RNF6; E3 ubiquitin-protein ligase mediating ’Lys-48’-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates ’Lys-6’ and ’Lys-27’-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator; Ring finger proteins	0.433
SEC22A	ZNF414	ENSP00000310521	ENSP00000377504	Vesicle-trafficking protein SEC22a; May be involved in vesicle transport between the ER and the Golgi complex; SNAREs	Zinc finger protein 414; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	0.543
TMEM63B	ZNF414	ENSP00000259746	ENSP00000377504	CSC1-like protein 2; Acts as an osmosensitive calcium-permeable cation channel	Zinc finger protein 414; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	0.527
ZNF414	C19orf54	ENSP00000377504	ENSP00000367564	Zinc finger protein 414; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	UPF0692 protein C19orf54; Chromosome 19 open reading frame 54; Belongs to the UPF0692 family	0.537
ZNF414	CCDC97	ENSP00000377504	ENSP00000269967	Zinc finger protein 414; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	Coiled-coil domain containing 97	0.599
ZNF414	DEPDC5	ENSP00000377504	ENSP00000383105	Zinc finger protein 414; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	GATOR complex protein DEPDC5; As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway	0.523
ZNF414	KDM4A	ENSP00000377504	ENSP00000361473	Zinc finger protein 414; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	Lysine-specific demethylase 4A; Histone demethylase that specifically demethylates ’Lys- 9’ and ’Lys-36’ residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-4’, H3 ’Lys-27’ nor H4 ’Lys-20’. Demethylates trimethylated H3 ’Lys-9’ and H3 ’Lys-36’ residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively; Lysi [...]	0.580

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