node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARF6 | FBXO8 | ENSP00000298316 | ENSP00000377280 | ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Involved in epithelial polarization (By similarity).Functions as an allosteric acti [...] | F-box only protein 8; May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential); F-boxes other | 0.979 |
ARL10 | ARL16 | ENSP00000308496 | ENSP00000380635 | ADP-ribosylation factor-like protein 10; ADP ribosylation factor like GTPase 10; Belongs to the small GTPase superfamily. Arf family | ADP-ribosylation factor-like protein 16; ADP ribosylation factor like GTPase 16; ARF GTPase family | 0.588 |
ARL10 | FBXO8 | ENSP00000308496 | ENSP00000377280 | ADP-ribosylation factor-like protein 10; ADP ribosylation factor like GTPase 10; Belongs to the small GTPase superfamily. Arf family | F-box only protein 8; May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential); F-boxes other | 0.642 |
ARL16 | ARL10 | ENSP00000380635 | ENSP00000308496 | ADP-ribosylation factor-like protein 16; ADP ribosylation factor like GTPase 16; ARF GTPase family | ADP-ribosylation factor-like protein 10; ADP ribosylation factor like GTPase 10; Belongs to the small GTPase superfamily. Arf family | 0.588 |
ARL16 | FBXO8 | ENSP00000380635 | ENSP00000377280 | ADP-ribosylation factor-like protein 16; ADP ribosylation factor like GTPase 16; ARF GTPase family | F-box only protein 8; May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential); F-boxes other | 0.642 |
FBXO16 | FBXO34 | ENSP00000369604 | ENSP00000313159 | F-box only protein 16; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation; F-boxes other | F-box only protein 34; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | 0.769 |
FBXO16 | FBXO36 | ENSP00000369604 | ENSP00000283946 | F-box only protein 16; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation; F-boxes other | F-box only protein 36; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | 0.750 |
FBXO16 | FBXO8 | ENSP00000369604 | ENSP00000377280 | F-box only protein 16; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation; F-boxes other | F-box only protein 8; May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential); F-boxes other | 0.651 |
FBXO34 | FBXO16 | ENSP00000313159 | ENSP00000369604 | F-box only protein 34; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | F-box only protein 16; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation; F-boxes other | 0.769 |
FBXO34 | FBXO36 | ENSP00000313159 | ENSP00000283946 | F-box only protein 34; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | F-box only protein 36; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | 0.805 |
FBXO34 | FBXO8 | ENSP00000313159 | ENSP00000377280 | F-box only protein 34; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | F-box only protein 8; May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential); F-boxes other | 0.662 |
FBXO36 | FBXO16 | ENSP00000283946 | ENSP00000369604 | F-box only protein 36; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | F-box only protein 16; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation; F-boxes other | 0.750 |
FBXO36 | FBXO34 | ENSP00000283946 | ENSP00000313159 | F-box only protein 36; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | F-box only protein 34; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | 0.805 |
FBXO36 | FBXO8 | ENSP00000283946 | ENSP00000377280 | F-box only protein 36; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | F-box only protein 8; May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential); F-boxes other | 0.715 |
FBXO8 | ARF6 | ENSP00000377280 | ENSP00000298316 | F-box only protein 8; May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential); F-boxes other | ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Involved in epithelial polarization (By similarity).Functions as an allosteric acti [...] | 0.979 |
FBXO8 | ARL10 | ENSP00000377280 | ENSP00000308496 | F-box only protein 8; May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential); F-boxes other | ADP-ribosylation factor-like protein 10; ADP ribosylation factor like GTPase 10; Belongs to the small GTPase superfamily. Arf family | 0.642 |
FBXO8 | ARL16 | ENSP00000377280 | ENSP00000380635 | F-box only protein 8; May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential); F-boxes other | ADP-ribosylation factor-like protein 16; ADP ribosylation factor like GTPase 16; ARF GTPase family | 0.642 |
FBXO8 | FBXO16 | ENSP00000377280 | ENSP00000369604 | F-box only protein 8; May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential); F-boxes other | F-box only protein 16; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation; F-boxes other | 0.651 |
FBXO8 | FBXO34 | ENSP00000377280 | ENSP00000313159 | F-box only protein 8; May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential); F-boxes other | F-box only protein 34; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | 0.662 |
FBXO8 | FBXO36 | ENSP00000377280 | ENSP00000283946 | F-box only protein 8; May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential); F-boxes other | F-box only protein 36; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other | 0.715 |