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  • 11.0 [archived version]
STRINGSTRING
IQSEC3 IQSEC3 PI4KA PI4KA DOPEY2 DOPEY2 MON2 MON2 GBF1 GBF1 ARL1 ARL1 VPS35 VPS35 ARL10 ARL10 SYS1 SYS1 DOPEY1 DOPEY1 ARL16 ARL16
"MON2" - Protein MON2 homolog in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
MON2Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Armadillo-like helical domain containing (1717 aa)    
Predicted Functional Partners:
DOPEY1
Protein dopey-1; May be involved in protein traffic between late Golgi and early endosomes (2476 aa)
     
 
  0.923
ARL16
ADP-ribosylation factor-like protein 16; ADP ribosylation factor like GTPase 16; ARF GTPase family (197 aa)
       
 
  0.922
ARL1
ADP-ribosylation factor-like protein 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus; ARF GTPase family (181 aa)
       
 
  0.907
ARL10
ADP-ribosylation factor-like protein 10; ADP ribosylation factor like GTPase 10; Belongs to the small GTPase superfamily. Arf family (244 aa)
       
 
  0.872
DOPEY2
Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family (2298 aa)
     
 
  0.858
GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1; Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES), a [...] (1859 aa)
     
 
  0.813
VPS35
Vacuolar protein sorting-associated protein 35; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may [...] (796 aa)
     
 
  0.787
SYS1
Protein SYS1 homolog; Involved in protein trafficking. May serve as a receptor for ARFRP1; Belongs to the SYS1 family (156 aa)
       
 
  0.770
PI4KA
Phosphatidylinositol 4-kinase alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily (2102 aa)
     
 
  0.760
IQSEC3
IQ motif and SEC7 domain-containing protein 3; Acts as a guanine nucleotide exchange factor (GEF) for ARF1 (1182 aa)
     
 
  0.757
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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