node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARL1 | DOPEY1 | ENSP00000261636 | ENSP00000237163 | ADP-ribosylation factor-like protein 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus; ARF GTPase family | Protein dopey-1; May be involved in protein traffic between late Golgi and early endosomes | 0.436 |
ARL1 | DOPEY2 | ENSP00000261636 | ENSP00000382104 | ADP-ribosylation factor-like protein 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus; ARF GTPase family | Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family | 0.436 |
ARL1 | GBF1 | ENSP00000261636 | ENSP00000359000 | ADP-ribosylation factor-like protein 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus; ARF GTPase family | Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1; Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES), a [...] | 0.801 |
ARL1 | MON2 | ENSP00000261636 | ENSP00000377250 | ADP-ribosylation factor-like protein 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus; ARF GTPase family | Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Armadillo-like helical domain containing | 0.907 |
ARL1 | SYS1 | ENSP00000261636 | ENSP00000243918 | ADP-ribosylation factor-like protein 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus; ARF GTPase family | Protein SYS1 homolog; Involved in protein trafficking. May serve as a receptor for ARFRP1; Belongs to the SYS1 family | 0.938 |
ARL10 | ARL16 | ENSP00000308496 | ENSP00000380635 | ADP-ribosylation factor-like protein 10; ADP ribosylation factor like GTPase 10; Belongs to the small GTPase superfamily. Arf family | ADP-ribosylation factor-like protein 16; ADP ribosylation factor like GTPase 16; ARF GTPase family | 0.588 |
ARL10 | GBF1 | ENSP00000308496 | ENSP00000359000 | ADP-ribosylation factor-like protein 10; ADP ribosylation factor like GTPase 10; Belongs to the small GTPase superfamily. Arf family | Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1; Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES), a [...] | 0.453 |
ARL10 | MON2 | ENSP00000308496 | ENSP00000377250 | ADP-ribosylation factor-like protein 10; ADP ribosylation factor like GTPase 10; Belongs to the small GTPase superfamily. Arf family | Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Armadillo-like helical domain containing | 0.872 |
ARL10 | SYS1 | ENSP00000308496 | ENSP00000243918 | ADP-ribosylation factor-like protein 10; ADP ribosylation factor like GTPase 10; Belongs to the small GTPase superfamily. Arf family | Protein SYS1 homolog; Involved in protein trafficking. May serve as a receptor for ARFRP1; Belongs to the SYS1 family | 0.414 |
ARL16 | ARL10 | ENSP00000380635 | ENSP00000308496 | ADP-ribosylation factor-like protein 16; ADP ribosylation factor like GTPase 16; ARF GTPase family | ADP-ribosylation factor-like protein 10; ADP ribosylation factor like GTPase 10; Belongs to the small GTPase superfamily. Arf family | 0.588 |
ARL16 | DOPEY1 | ENSP00000380635 | ENSP00000237163 | ADP-ribosylation factor-like protein 16; ADP ribosylation factor like GTPase 16; ARF GTPase family | Protein dopey-1; May be involved in protein traffic between late Golgi and early endosomes | 0.428 |
ARL16 | GBF1 | ENSP00000380635 | ENSP00000359000 | ADP-ribosylation factor-like protein 16; ADP ribosylation factor like GTPase 16; ARF GTPase family | Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1; Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES), a [...] | 0.453 |
ARL16 | MON2 | ENSP00000380635 | ENSP00000377250 | ADP-ribosylation factor-like protein 16; ADP ribosylation factor like GTPase 16; ARF GTPase family | Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Armadillo-like helical domain containing | 0.922 |
ARL16 | SYS1 | ENSP00000380635 | ENSP00000243918 | ADP-ribosylation factor-like protein 16; ADP ribosylation factor like GTPase 16; ARF GTPase family | Protein SYS1 homolog; Involved in protein trafficking. May serve as a receptor for ARFRP1; Belongs to the SYS1 family | 0.523 |
DOPEY1 | ARL1 | ENSP00000237163 | ENSP00000261636 | Protein dopey-1; May be involved in protein traffic between late Golgi and early endosomes | ADP-ribosylation factor-like protein 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus; ARF GTPase family | 0.436 |
DOPEY1 | ARL16 | ENSP00000237163 | ENSP00000380635 | Protein dopey-1; May be involved in protein traffic between late Golgi and early endosomes | ADP-ribosylation factor-like protein 16; ADP ribosylation factor like GTPase 16; ARF GTPase family | 0.428 |
DOPEY1 | MON2 | ENSP00000237163 | ENSP00000377250 | Protein dopey-1; May be involved in protein traffic between late Golgi and early endosomes | Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Armadillo-like helical domain containing | 0.923 |
DOPEY1 | VPS35 | ENSP00000237163 | ENSP00000299138 | Protein dopey-1; May be involved in protein traffic between late Golgi and early endosomes | Vacuolar protein sorting-associated protein 35; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may [...] | 0.418 |
DOPEY2 | ARL1 | ENSP00000382104 | ENSP00000261636 | Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family | ADP-ribosylation factor-like protein 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus; ARF GTPase family | 0.436 |
DOPEY2 | MON2 | ENSP00000382104 | ENSP00000377250 | Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family | Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Armadillo-like helical domain containing | 0.858 |