| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATP6AP1 | FAM50A | ENSP00000358777 | ENSP00000377225 | V-type proton ATPase subunit S1; Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles. Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity. Involved in membrane trafficking and Ca(2+)-dependent membrane fusion. May play a role in the assembly of the V-type ATPase complex. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the [...] | Protein FAM50A; May be a DNA-binding protein or transcriptional factor; Spliceosomal C complex | 0.554 |
| CIAPIN1 | FAM50A | ENSP00000377914 | ENSP00000377225 | Anamorsin; Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Electrons are transferred to the Fe-S cluster from NADPH via the FAD- and FMN-containing protein NDOR1 | Protein FAM50A; May be a DNA-binding protein or transcriptional factor; Spliceosomal C complex | 0.457 |
| FAM50A | ATP6AP1 | ENSP00000377225 | ENSP00000358777 | Protein FAM50A; May be a DNA-binding protein or transcriptional factor; Spliceosomal C complex | V-type proton ATPase subunit S1; Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles. Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity. Involved in membrane trafficking and Ca(2+)-dependent membrane fusion. May play a role in the assembly of the V-type ATPase complex. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the [...] | 0.554 |
| FAM50A | CIAPIN1 | ENSP00000377225 | ENSP00000377914 | Protein FAM50A; May be a DNA-binding protein or transcriptional factor; Spliceosomal C complex | Anamorsin; Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Electrons are transferred to the Fe-S cluster from NADPH via the FAD- and FMN-containing protein NDOR1 | 0.457 |
| FAM50A | METTL2A | ENSP00000377225 | ENSP00000309610 | Protein FAM50A; May be a DNA-binding protein or transcriptional factor; Spliceosomal C complex | Methyltransferase-like protein 2A; Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs | 0.494 |
| FAM50A | NAPA | ENSP00000377225 | ENSP00000263354 | Protein FAM50A; May be a DNA-binding protein or transcriptional factor; Spliceosomal C complex | Alpha-soluble NSF attachment protein; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane; Belongs to the SNAP family | 0.509 |
| FAM50A | NSFL1C | ENSP00000377225 | ENSP00000418529 | Protein FAM50A; May be a DNA-binding protein or transcriptional factor; Spliceosomal C complex | NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro); Belongs to the NSFL1C family | 0.543 |
| FAM50A | PDAP1 | ENSP00000377225 | ENSP00000222968 | Protein FAM50A; May be a DNA-binding protein or transcriptional factor; Spliceosomal C complex | 28 kDa heat- and acid-stable phosphoprotein; Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB | 0.530 |
| FAM50A | RSU1 | ENSP00000377225 | ENSP00000367154 | Protein FAM50A; May be a DNA-binding protein or transcriptional factor; Spliceosomal C complex | Ras suppressor protein 1; Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro | 0.472 |
| FAM50A | SF3B3 | ENSP00000377225 | ENSP00000305790 | Protein FAM50A; May be a DNA-binding protein or transcriptional factor; Spliceosomal C complex | Splicing factor 3B subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron | 0.571 |
| FAM50A | THOC2 | ENSP00000377225 | ENSP00000245838 | Protein FAM50A; May be a DNA-binding protein or transcriptional factor; Spliceosomal C complex | THO complex subunit 2; Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5’ end of the mRNA where it functions in mRNA export to the cyt [...] | 0.465 |
| FAM50A | TPD52L2 | ENSP00000377225 | ENSP00000217121 | Protein FAM50A; May be a DNA-binding protein or transcriptional factor; Spliceosomal C complex | Tumor protein D52 like 2 | 0.519 |
| METTL2A | FAM50A | ENSP00000309610 | ENSP00000377225 | Methyltransferase-like protein 2A; Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs | Protein FAM50A; May be a DNA-binding protein or transcriptional factor; Spliceosomal C complex | 0.494 |
| NAPA | FAM50A | ENSP00000263354 | ENSP00000377225 | Alpha-soluble NSF attachment protein; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plasma membrane; Belongs to the SNAP family | Protein FAM50A; May be a DNA-binding protein or transcriptional factor; Spliceosomal C complex | 0.509 |
| NSFL1C | FAM50A | ENSP00000418529 | ENSP00000377225 | NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro); Belongs to the NSFL1C family | Protein FAM50A; May be a DNA-binding protein or transcriptional factor; Spliceosomal C complex | 0.543 |
| NSFL1C | PDAP1 | ENSP00000418529 | ENSP00000222968 | NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro); Belongs to the NSFL1C family | 28 kDa heat- and acid-stable phosphoprotein; Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB | 0.453 |
| NSFL1C | RSU1 | ENSP00000418529 | ENSP00000367154 | NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro); Belongs to the NSFL1C family | Ras suppressor protein 1; Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro | 0.413 |
| NSFL1C | TPD52L2 | ENSP00000418529 | ENSP00000217121 | NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro); Belongs to the NSFL1C family | Tumor protein D52 like 2 | 0.431 |
| PDAP1 | FAM50A | ENSP00000222968 | ENSP00000377225 | 28 kDa heat- and acid-stable phosphoprotein; Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB | Protein FAM50A; May be a DNA-binding protein or transcriptional factor; Spliceosomal C complex | 0.530 |
| PDAP1 | NSFL1C | ENSP00000222968 | ENSP00000418529 | 28 kDa heat- and acid-stable phosphoprotein; Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB | NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro); Belongs to the NSFL1C family | 0.453 |
