| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCDC39 | HYDIN | ENSP00000405708 | ENSP00000377197 | Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly | Hydrocephalus-inducing protein homolog; Required for ciliary motility; Protein phosphatase 1 regulatory subunits | 0.781 |
| CCDC39 | RSPH4A | ENSP00000405708 | ENSP00000229554 | Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly | Radial spoke head protein 4 homolog A; Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk which is attached to a subfiber of the outer doublet microtubule, and a bulbous head which is attached to the stalk and appears to interact with the projections from the central pair of microtubules | 0.835 |
| CCDC39 | RSPH9 | ENSP00000405708 | ENSP00000361238 | Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly | Radial spoke head 9 homolog | 0.853 |
| GPRIN2 | HYDIN | ENSP00000363436 | ENSP00000377197 | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth | Hydrocephalus-inducing protein homolog; Required for ciliary motility; Protein phosphatase 1 regulatory subunits | 0.841 |
| GPRIN2 | NBPF1 | ENSP00000363436 | ENSP00000474456 | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth | Neuroblastoma breakpoint family member 1; NBPF member 1 | 0.801 |
| GPRIN2 | NBPF12 | ENSP00000363436 | ENSP00000478609 | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth | Neuroblastoma breakpoint family member 1; NBPF member 12 | 0.800 |
| GPRIN2 | NPEPPS | ENSP00000363436 | ENSP00000320324 | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth | Puromycin-sensitive aminopeptidase; Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain; Aminopeptidases | 0.800 |
| GPRIN2 | SRGAP2 | ENSP00000363436 | ENSP00000459615 | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth | SLIT-ROBO Rho GTPase-activating protein 2; RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral c [...] | 0.800 |
| GPRIN2 | SRGAP3 | ENSP00000363436 | ENSP00000373347 | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth | SLIT-ROBO Rho GTPase-activating protein 3; GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons; F-BAR domain containing | 0.800 |
| GPRIN2 | UGT2B17 | ENSP00000363436 | ENSP00000320401 | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth | UDP-glucuronosyltransferase 2B17; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT); Minor histocompatibility antigens | 0.801 |
| HYDIN | CCDC39 | ENSP00000377197 | ENSP00000405708 | Hydrocephalus-inducing protein homolog; Required for ciliary motility; Protein phosphatase 1 regulatory subunits | Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly | 0.781 |
| HYDIN | GPRIN2 | ENSP00000377197 | ENSP00000363436 | Hydrocephalus-inducing protein homolog; Required for ciliary motility; Protein phosphatase 1 regulatory subunits | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth | 0.841 |
| HYDIN | NBPF1 | ENSP00000377197 | ENSP00000474456 | Hydrocephalus-inducing protein homolog; Required for ciliary motility; Protein phosphatase 1 regulatory subunits | Neuroblastoma breakpoint family member 1; NBPF member 1 | 0.803 |
| HYDIN | NBPF12 | ENSP00000377197 | ENSP00000478609 | Hydrocephalus-inducing protein homolog; Required for ciliary motility; Protein phosphatase 1 regulatory subunits | Neuroblastoma breakpoint family member 1; NBPF member 12 | 0.801 |
| HYDIN | NPEPPS | ENSP00000377197 | ENSP00000320324 | Hydrocephalus-inducing protein homolog; Required for ciliary motility; Protein phosphatase 1 regulatory subunits | Puromycin-sensitive aminopeptidase; Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain; Aminopeptidases | 0.802 |
| HYDIN | RSPH4A | ENSP00000377197 | ENSP00000229554 | Hydrocephalus-inducing protein homolog; Required for ciliary motility; Protein phosphatase 1 regulatory subunits | Radial spoke head protein 4 homolog A; Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk which is attached to a subfiber of the outer doublet microtubule, and a bulbous head which is attached to the stalk and appears to interact with the projections from the central pair of microtubules | 0.796 |
| HYDIN | RSPH9 | ENSP00000377197 | ENSP00000361238 | Hydrocephalus-inducing protein homolog; Required for ciliary motility; Protein phosphatase 1 regulatory subunits | Radial spoke head 9 homolog | 0.805 |
| HYDIN | SRGAP2 | ENSP00000377197 | ENSP00000459615 | Hydrocephalus-inducing protein homolog; Required for ciliary motility; Protein phosphatase 1 regulatory subunits | SLIT-ROBO Rho GTPase-activating protein 2; RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral c [...] | 0.810 |
| HYDIN | SRGAP3 | ENSP00000377197 | ENSP00000373347 | Hydrocephalus-inducing protein homolog; Required for ciliary motility; Protein phosphatase 1 regulatory subunits | SLIT-ROBO Rho GTPase-activating protein 3; GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons; F-BAR domain containing | 0.805 |
| HYDIN | UGT2B17 | ENSP00000377197 | ENSP00000320401 | Hydrocephalus-inducing protein homolog; Required for ciliary motility; Protein phosphatase 1 regulatory subunits | UDP-glucuronosyltransferase 2B17; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT); Minor histocompatibility antigens | 0.802 |
